Endoscopic treatment of cholangiocarcinoma and carcinoma of the duodenal papilla by intraductal high-intensity US: Results of a pilot study

Prat, Frédéric; Lafon, Cyril; Lima, David Melo de; Theilliere, Yves; Fritsch, Jacques; Pelletier, G; Buffet, Catherine; Cathignol, D.

doi:10.1016/s0016-5107(02)70374-x

Cited by 52 publications

(20 citation statements)

References 25 publications

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“…We were limited in this work by the lack of any easily reproducible cancerous target in the porcine liver, which would enable us to study the antitumor effect of ultrasound destruction. However, a similar transducer has already been used endoscopically by Prat et al and has proved efficient in tumor tissue destruction in the case of cholangiocarcinoma and duodenal papillary carcinoma [15,16,22]. Small and focally, some medium-sized vessels up to 500 m showed major alterations: in (C) (ϫ150), a medium-sized artery presents disruption of the endothelial lining and incipient intra-luminal thrombus (*); adjacent veins are markedly dilated and congestive (C), (D).…”

Section: Discussionmentioning

confidence: 99%

Developing an Interstitial Ultrasound Applicator for Thermal Ablation in Liver: Results of Animal Experiments

Seket

Lafon

Mithieux

et al. 2007

Journal of Surgical Research

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Section: Discussionmentioning

confidence: 99%

Developing an Interstitial Ultrasound Applicator for Thermal Ablation in Liver: Results of Animal Experiments

Seket

Lafon

Mithieux

et al. 2007

Journal of Surgical Research

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“…Prat et al [57] conducted a pilot study in 10 patients receiving high-intensity intraductal ultrasound therapy, six of whom had CC. They reported an objective reduction in tumor size in three of the six patients, with the bile duct specimen negative for malignancy in one of the patients who subsequently underwent surgery and complete regression of CC in another patient, allowing for permanent stent removal (follow-up of 30 months).…”

Section: High-intensity Intraductal Ultrasoundmentioning

confidence: 99%

Diagnosis and management of cholangiocarcinoma

Sandhu

Roberts

2008

Curr Gastroenterol Rep

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Cholangiocarcinoma (CC) is a rare yet frequently fatal tumor that causes significant morbidity and mortality due to late presentation. Radiology is the mainstay of CC diagnosis; however, advances in understanding the pathogenesis of CC, including the role of oncogenes, inflammation-mediated genomic instability, and interleukin-6/STAT-3 signaling pathways, may allow development of new diagnostic and prognostic markers and targets for CC therapy. Although surgical resection is the standard of care for resectable CC, liver transplantation has shown excellent results in selected patients. The use of chemotherapy and radiotherapy are currently limited by marginal response rates, toxicity, and biliary complications. Locally ablative therapies in the form of transcatheter arterial chemoembolization and radioembolization are under investigation. Molecular therapies (eg, epidermal growth factor receptor, ErbB-2, and vascular endothelial growth factor receptor antagonists) and immunotherapy using diabodies are also under investigation for treatment of unresectable CC.

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“…Histologically, highly reproducible and sharply demarcated uniform cylinders of coagulative necrosis of the tumor tissue were seen after a 5-minute exposure to ultrasound waves. More recently, Prat et al [50,51] published a case report and the results of a pilot study on the use of HIIUS in 10 patients with biliary tract malignancy, six of whom had CCA. The outcome measure was a reduction in the length of the stricture determined by ERCP, reduction in tumor size determined by EUS, and the absence of malignant cells or high…”

Section: Intraluminal Brachytherapymentioning

confidence: 99%

Cholangiocarcinoma

Chahal

Baron

2005

Curr Treat Options Gastro

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Cholangiocarcinoma is an uncommon malignant tumor arising from biliary epithelium. The incidence increases with age and usually affects individuals in their sixth or seventh decade of life. Most patients clinically present with features of biliary obstruction. Although surgical resection offers the only hope for cure, the majority of patients are found to have unresectable disease on initial presentation and carry extremely grim prognosis. This has lead to an emphasis on the role of palliative care, with the relief of biliary obstruction being the primary goal in the management of these patients. Surgical bypass was once considered as the primary means of palliating biliary obstruction, but nonsurgical placement of biliary stents is associated with lower morbidity and mortality. Newer modalities such as photodynamic therapy, brachytherapy, and high-intensity ultrasound therapy may result in improved survival and play a future role as an adjunctive therapy to surgical resection.

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Endoscopic treatment of cholangiocarcinoma and carcinoma of the duodenal papilla by intraductal high-intensity US: Results of a pilot study

Cited by 52 publications

References 25 publications

Developing an Interstitial Ultrasound Applicator for Thermal Ablation in Liver: Results of Animal Experiments

Developing an Interstitial Ultrasound Applicator for Thermal Ablation in Liver: Results of Animal Experiments

Diagnosis and management of cholangiocarcinoma

Cholangiocarcinoma

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