Endoscopic submucosal dissection versus surgical resection for early gastric cancer: a retrospective multicenter study on immediate and long-term outcome over 5 years

Ryu, Seung Jee; Kim, Byung‐Wook; Kim, Boo Gyeong; Kim, Jihee; Kim, Joon Sung; Kim, Sang Hyun; Park, Jae Myung; Oh, Jung-Hwan; Kim, Tae Ho; Kim, Jin-Jo; Park, Seungman; Park, Cho Hyun; Song, Kyo Young; Lee, Jun Hyun; Kim, Sung Geun; Kim, Dong Jin; Kim, Wook

doi:10.1007/s00464-016-4877-y

Cited by 53 publications

(37 citation statements)

References 17 publications

(21 reference statements)

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“…Large series from East Asia show high en bloc resection (86–97%) and curative resection (R0) rates (88–93%) for EGC treated by ESD . Local recurrence rate after gastric ESD is approximately 1–2% per annum, with 5‐year overall survival of 96–100% and 5‐year disease‐free survival of 97–100% . Two meta‐analyses evaluating ESD versus EMR for treatment of EGC found higher rates of en bloc (92% vs 52%, respectively) and R0 (82–92% vs 42–43%, respectively) resection and less local recurrence (0.8% vs 5.0–6.4%, respectively) .…”

Section: Role Of Esd: Comparing Outcomes For Early Gastrointestinal Tmentioning

confidence: 99%

“…Delayed bleeding rate was 6%, and perforation rate was 1% . In comparison, large multicenter studies of ESD for EGC at major Eastern institutions report similar en bloc resection rates of 92.7–96.1% and R0 resection rates of 82.6–94.5%, with bleeding rates of 0.6–9.9% and perforation rates of 3.6–4.7% …”

Section: Current Status Of Endoscopic Submucosal Dissection In Westermentioning

confidence: 99%

“…[9][10][11][12][13][14] Local recurrence rate after gastric ESD is approximately 1-2% per annum, 15 with 5-year overall survival of 96-100% and 5-year diseasefree survival of 97-100%. 9,16 Two meta-analyses evaluating ESD versus EMR for treatment of EGC found higher rates of en bloc (92% vs 52%, respectively) and R0 (82-92% vs 42-43%, respectively) resection and less local recurrence (0.8% vs 5.0-6.4%, respectively). 7,8 Despite favorable ESD outcomes, no mortality difference between ESD and EMR was detected after mean follow up of 36-43 months.…”

Section: Role Of Esd: Comparing Outcomes For Early Gastrointestinal Tmentioning

confidence: 99%

“…70 In comparison, large multicenter studies of ESD for EGC at major Eastern institutions report similar en bloc resection rates of 92.7-96.1% and R0 resection rates of 82.6-94.5%, 67,[75][76][77] with bleeding rates of 0.6-9.9% and perforation rates of 3.6-4.7%. 16,67,75,77 Esophagus Superficial esophageal SCC involving the epithelium (m1) or lamina propria (m2) has virtually no risk of lymph node metastasis. For SCC invading the muscularis mucosae (m3), risk of lymph node invasion is 8-18% overall, but is reported as low as 4.7% for G1-2 lesions without LVI.…”

Section: Stomachmentioning

confidence: 99%

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Endoscopic submucosal dissection in the West: Current status and future directions

Michael

Bourke

2017

Digestive Endoscopy

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Endoscopic submucosal dissection (ESD) was first conceptually described almost 30 years ago in Japan and is now widely practiced throughout East Asia. ESD expands the boundaries of endoscopic resection (ER) by allowing en bloc resection of large early neoplastic lesions within the gastrointestinal tract (GIT). This offers advantages over other ER techniques by facilitating definitive histological staging and curative treatment of early cancer in selected cases. Indeed, the experience of ESD in Eastern countries is significant, and excellent outcomes from high-volume centers are reported. The potential benefits of ESD are recognized by Western endoscopists, but its adoption has been limited. A number of factors contribute to this, including epidemiological differences in GIT neoplasia between Western and Eastern populations and limitations in training opportunities. In this review, we discuss the role of ESD, its current status and the future in Western endoscopic practice.

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Section: Role Of Esd: Comparing Outcomes For Early Gastrointestinal Tmentioning

confidence: 99%

Section: Current Status Of Endoscopic Submucosal Dissection In Westermentioning

confidence: 99%

Section: Role Of Esd: Comparing Outcomes For Early Gastrointestinal Tmentioning

confidence: 99%

Section: Stomachmentioning

confidence: 99%

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Endoscopic submucosal dissection in the West: Current status and future directions

Michael

Bourke

2017

Digestive Endoscopy

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“…Since the development of endoscopic techniques in recent decades, ESD has been accepted as a popular treatment option for EGC or GST in China and Korea, [26,27] whose features meet the ESD absolute indication even expanded indication. Several previous studies have compared the use of ESD and surgery for EGC or GST resection in different populations.…”

Section: Discussionmentioning

confidence: 99%

Concomitant stromal tumor and early cancer of the stomach

Xu¹,

Liang-fang²,

Lu³

et al. 2017

Medicine

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Concomitant gastric stromal tumor (GST) and gastric cancer (GC) is uncommon; even more uncommon is a concomitant GST and early stage GC (EGC). Tumor resection by endoscopic submucosal dissection (ESD) for concomitant GST and EGC has not been reported. We sought to define the clinical importance of detection of concomitant GST and EGC during the first esophagogastroduodenoscopy (EGD), and compare the clinical outcomes of ESD versus radical surgery for the treatment of concomitant GST and EGC. Our investigation was a retrospective cohort study. Patients with concomitant GST and EGC who underwent ESD or radical surgery were enrolled at the university-affiliated hospital from January 2005 to January 2015. The detection rate of concomitant GST and EGC during the first EGD was 3/25 (12%). Among 25 patients, 14 underwent ESD and 11 underwent surgery. Mean operation time and hospital stay were significantly shorter in the ESD group than the surgery group. There were no significant differences in terms of rates of en bloc resection, complete resection, and early complications. Late complications were more common in the surgery group than in the ESD group. The median follow-up duration was 58.9 months. Three- or 5-year overall survival rates were 100% for both groups and no patient died of EGC and GST. There was no local recurrence in the 2 groups; however, 3 metachronous EGC lesions were found during the follow-up period in the ESD group as follows: the simultaneous occurrence of GST and EGC was uncommon; the detection rate of concomitant GST and EGC was very low at the first EGD; and ESD appeared to be a safe, efficient, and popular treatment option for concomitant GST and EGC, that met the ESD absolute indication, and the outcomes were comparable to those achieved with surgery.

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Prophylactic effect of compression stockings for elevated D‐dimer levels following endoscopic submucosal dissection

Harada,

Kodashima,

Ikusaka

et al. 2024

DEN Open

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ObjectivesA relationship between endoscopic submucosal dissection (ESD) and deep vein thrombosis has been recognized. We previously reported that a high corrected midazolam dose (total midazolam dose/initial dose of midazolam used to induce sedation) is related to elevated D‐dimer levels after ESD. In this study, the effect of compression stockings (CSs) in preventing thrombosis following ESD under sedation was evaluated by measuring D‐dimer levels before and after ESD.MethodsThe participants were patients who underwent ESD for upper gastrointestinal tumors during the period between April 2018 and October 2022. Patients with pre‐ESD D‐dimer levels ≥1.6 µg/m and patients with corrected midazolam doses ≤3.0 were excluded. A retrospective investigation of the relationship between CS use and high post‐ESD D‐dimer levels (difference in D‐dimer levels ≥1.0 µg/mL between before and after ESD) was conducted.ResultsThere were 27 patients in the non‐CS group (NCS) and 33 patients in the CS group. The number of patients with high post‐ESD D‐dimer levels was 13 (48.2%) in the non‐CS group and six (18.2%) in the CS group; the number in the CS group was significantly lower (p = 0.024). On logistic regression analysis, a relationship was seen between the wearing of CSs and a lower number of patients with high post‐ESD D‐dimer levels (odds ratio 0.24, 95% confidence interval 0.08–0.79, p = 0.019).ConclusionWearing CSs was related to a lower risk of high post‐ESD D‐dimer levels. This result suggests that thrombus formation is a cause of elevated D‐dimer levels after ESD.

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Endoscopic submucosal dissection versus surgical resection for early gastric cancer: a retrospective multicenter study on immediate and long-term outcome over 5 years

Cited by 53 publications

References 17 publications

Endoscopic submucosal dissection in the West: Current status and future directions

Endoscopic submucosal dissection in the West: Current status and future directions

Concomitant stromal tumor and early cancer of the stomach

Prophylactic effect of compression stockings for elevated D‐dimer levels following endoscopic submucosal dissection

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