Endoscopic retrograde cholangiopancreatography in children with symptomatic pancreaticobiliary maljunction: A retrospective multicenter study

Zeng, Jingqing; Deng, Zhongwei; Yang, Kun; Zhang, Tian-Ao; Wang, Wenyu; Ji, Jianmei; Hu, Yabin; Che, Xu; Gong, Bo

doi:10.3748/wjg.v25.i40.6107

Cited by 17 publications

(15 citation statements)

References 22 publications

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“…Coutinho et al [ 13 ] found that patients treated with ERCP had quicker pain alleviation and hospitalization times than those treated with conservative methods. Pancreatitis, gastrointestinal hemorrhage, and infection were reported to occur in approximately 16.0 percent of the children treated with endoscopic retrograde cholangiopancreatography (ERCP), extracorporeal shock therapy (EST), drainage, and lithotomy by Zeng et al [ 14 ]. In this experiment, the observation group's hospital stay was shorter than the control group's, as was the time to alleviate stomach discomfort and normalize blood amylase levels.…”

Section: Discussionmentioning

confidence: 99%

CRP and ALT Levels in Individuals with Acute Biliary Pancreatitis after Endoscopic Retrograde Cholangiopancreatography and Endoscopic Sphincterotomy

Zhu

Sun

2022

Computational Intelligence and Neuroscience

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Objective. The goal of this study was to see how effective endoscopic retrograde cholangiopancreatography combined with endoscopic sphincterotomy was in treating acute biliary pancreatitis and how it affected CRP and ALT levels. Methods. This analysis is based on a 100-patient acute pancreatitis (ABP) study conducted at our institution from June 2019 to June 2020. They were divided into two groups of 50 cases each, the control group and the observational group, according to the random number table. Endoscopic sphincterotomy and ERCP were performed on the observation group instead of open surgery on the control group as a point of comparison (EST). The followings were compared including abdominal pain relief duration, blood amylase recovery duration, and hospital stay duration, as well as Serum C-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α) level; the ALT, AST, and GGT levels of the two groups were compared, as well as the occurrence of problems in both groups. Results. The observation group had a significantly shorter duration of abdominal pain, blood amylase recovery, and hospital stay. Presurgery CRP, IL-6, and TNF-α levels in both groups were significantly lower in the observation group than in the control group. According to the results of the study, both groups saw significant decreases in ALT, AST, and GGT after surgery; however, the levels of these markers in both groups were significantly lower in the observation group after surgery than in the control group. The observation group’s (14.00 percent) complication rate was substantially lower. Conclusion. ERCP and EST in the treatment of ABP can not only successfully improve clinical indexes and facilitate the recovery of patients but also reduce the levels of CRP and alt, reduce the level of inflammation, and enhance renal function, with reduced problems, which has a high clinical reference value.

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Section: Discussionmentioning

confidence: 99%

CRP and ALT Levels in Individuals with Acute Biliary Pancreatitis after Endoscopic Retrograde Cholangiopancreatography and Endoscopic Sphincterotomy

Zhu

Sun

2022

Computational Intelligence and Neuroscience

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“…With the advancement of endoscopy technology, ERCP intervention is an effective and relatively safe treatment for PBM. Zeng JQ reported that the effective rate of ERCP therapy for PBM was 82.4%, the rate of RAP was 11.8% ( 22 ). Troendle et al ( 23 ) suggest presence of ductal obstruction as a sign of likely clinical benefit with ERCP.…”

Section: Discussionmentioning

confidence: 99%

Clinical Characteristics of Paediatric Pancreatitis Caused by Pancreaticobiliary Malformation: A Single-Centre Retrospective Analysis

2021

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Background/Aims: To investigate the clinical profiles of children with pancreatitis caused by pancreaticobiliary malformation.Methods: We retrospectively analysed the clinical data of children diagnosed with pancreatitis at our institute from June 2017 to January 2021.Results: A total of 195 patients and 169 control subjects were included in this study. Twenty-six (13.3%) patients had pancreaticobiliary malformation-related pancreatitis. The average age of onset in the pancreaticobiliary malformation pancreatitis (PMP) group was lower than that in the non-PMP group, and the difference was statistically significant. The number of patients in the PMP group that had jaundice was significantly higher than that of the non-PMP group (P < 0.05). Logistic regression analysis showed that total bilirubin (TB) and γ-glutamyltransferase (GGT) (odds ratio = 1.096, P < 0.01) were independent predictors of pancreaticobiliary malformation-related pancreatitis in children. The positive detection rate of pancreaticobiliary malformation was 68% for abdominal ultrasound, 38.4% for abdominal enhanced computed tomography, and 91.3% for magnetic resonance cholangiopancreatography (MRCP). The recurrence rate (34.6%) in the PMP group was higher than that in the non-PMP group (15.4%, P < 0.05); surgical therapy had the lowest recurrence rate. Age at initial onset of pancreatitis was younger and the period to recurrence was shorter in the PMP group than in the non-PMP group (P < 0.05).Conclusion: Pancreaticobiliary malformation is one of the major causes of paediatric pancreatitis. Elevated TB and GGT in patients with pancreatitis may be suggestive for underlying pancreaticobiliary malformation not solely to pancreatitis. MRCP should be used when pancreatitis due to pancreaticobiliary malformation is suspected. Surgery or endoscopic retrograde cholangiopancreatography-guided intervention may be helpful but further study is needed.

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“…Whereas, considering that this technique is invasive, other diagnostic imaging techniques are preferred in patients with PBM. Before ERCP, all patients underwent initial tests, including trypsin test, liver function test, US, and MRCP to preliminarily evaluate the basic condition of the patients[ 16 ]. If MRCP or US indicates some diseases, such as biliary pancreatitis, obstructive jaundice, cholangitis, CBD dilatation, bile duct stones, or pancreatic obstruction, these diseases will increase the risk of surgery.…”

Section: Diagnostic Imaging Techniquesmentioning

confidence: 99%

Application of imaging techniques in pancreaticobiliary maljunction

Wang¹,

Mu²,

Xu³

et al. 2022

WJCC

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Imaging techniques are useful tools in the diagnosis and treatment of pancreaticobiliary maljunction (PBM). PBM is a precancerous lesion often relative to the disease of the pancreas and biliary tract, for example, cholecystolithiasis, protein plugs, and pancreatitis. For patients with PBM, early diagnosis and timely treatment are highly important, which is largely dependent on imaging techniques. The continuous development of imaging techniques, including endoscopic retrograde cholangiopancreatography, magnetic resonance cholangiopancreatography, computed tomography, ultrasound, and intraoperative cholangiography, has provided appropriate diagnostic and therapeutic tools for PBM. Imaging techniques, including non-invasive and invasive, have distinct advantages and disadvantages. The purpose of this paper is to review the application of various imaging techniques in the diagnosis and treatment of PBM.

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Endoscopic retrograde cholangiopancreatography in children with symptomatic pancreaticobiliary maljunction: A retrospective multicenter study

Cited by 17 publications

References 22 publications

CRP and ALT Levels in Individuals with Acute Biliary Pancreatitis after Endoscopic Retrograde Cholangiopancreatography and Endoscopic Sphincterotomy

CRP and ALT Levels in Individuals with Acute Biliary Pancreatitis after Endoscopic Retrograde Cholangiopancreatography and Endoscopic Sphincterotomy

Clinical Characteristics of Paediatric Pancreatitis Caused by Pancreaticobiliary Malformation: A Single-Centre Retrospective Analysis

Application of imaging techniques in pancreaticobiliary maljunction

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