Endoscopic Pyloric Injection of Botulinum Toxin for the Treatment of Postvagotomy Gastroparesis.

Endoscopic pyloric balloon dilatation obviates the need for pyloroplasty at esophagectomy

“…The efficacy of this approach is being studied, but at least one report suggests that the benefit lasts less than 6 months [22]. Obviously, our study does not address the value of pyloric injection of botulinum toxin-A, but a trial of pyloric dilatation versus pyloric injection of botulinum toxin-A might be reasonable if confirmatory prospective trials suggest that each treatment is effective.…”

The Long-Term Efficacy and Safety of Pyloroplasty Combined with Gastric Electrical Stimulation Therapy in Gastroparesis

“…Recent studies also demonstrated that injection of botulinum toxin into the pyloric muscle and the self-expanding covered metallic stents have reduced GP symptoms. 11 Surgical pyloroplasty facilitates rapid transit of nutrients thereby bypassing the trituration function of the stomach that is incapacitated in GP. 8 These treatment modalities have been prescribed separately or in combination with GES depending on the patient's constellation of symptoms.…”

Understanding the Differences Between Gastroparesis and Gastroparesis-Like Syndrome: Filling a GaPing Hole?

“…To date, one large, multicenter retrospective analysis of 30 patients with various forms of GP found an 86% clinical response after G-POEM, a finding that must be confirmed by the collection of longterm data and by the conduct of randomized trials [5]. Other methods to relieve pyloric resistance include botulinum toxin injection and self-expanding covered metallic stents that decrease GP symptoms [6]. Studies of this type should be interpreted with the understanding that a wide range of symptom response to pyloric interventions has been reported across studies using the same technique.…”