Endoscopic Patterns and Histopathological Features after Eradication Therapy in Helicobacter pylori-Associated Nodular Gastritis

Chen, Ming‐Jen; Shih, Shou‐Chuan; Wang, Tsang-En; Chan, Yu‐Jan; Chen, Chih‐Jen; Chang, Wen-Hsiung

doi:10.1007/s10620-007-0097-6

Cited by 15 publications

(20 citation statements)

References 15 publications

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“…Koh et al [32] found that the increase in gastritis score was dependent on the increase in H. pylori density and was significantly associated with the occurrence of NG. Also, Chen et al [27] in 2008 reported that after treatment of H. pylori , there was a significant improvement in scores for gastritis activity, bacterial colonization and follicular gastritis.…”

Section: Discussionmentioning

confidence: 99%

“…H. pylori is predominantly acquired in childhood, and NG has frequently been found in children undergoing endoscopy [6] ; however, NG is present in a minority of adult patients with H. pylori infection; it is unclear how and why that particular pattern develops in only a small proportion of adult patients. Variations in bacterial strains, host factors, or a complex interplay between host and bacterial factors have all been postulated as explanations [27] . H. pylori strains are genetically diverse and could be incapable of inducing constant immune response [28,29] .…”

Section: Discussionmentioning

confidence: 99%

“…In terms of host factors, cytokine gene polymorphisms influence mucosal cytokine expression, and an overly vigorous immune response might induce worse gastric inflammation [31] . Host polymorphism could also result in host-specific colonization or adaptation of certain bacterial strains [27] .…”

Section: Discussionmentioning

confidence: 99%

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Endoscopic Nodular Gastritis in Dyspeptic Adults: Prevalence and Association with <i>Helicobacter pylori</i> Infection

Alenezi¹,

Alsurayei²,

Aly

et al. 2009

Med Princ Pract

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Objective: To determine the prevalence and histological features of endoscopic nodular gastritis (NG) in adult dyspeptic patients and its relation to Helicobacter pylori infection. Subjects and Methods: A retrospective endoscopic report review of 2,142 patients identified 67 patients with NG during the period from 1 September 2006 to 31 August 2007. A subset of 32 NG patients (group 1) who had had gastric biopsies during upper gastrointestinal endoscopy and had been evaluated for H. pylori infection were compared to 32 age- and gender-matched dyspeptic patients. They had undergone endoscopy during the same period, which yielded normal results, and had available biopsies that were similarly evaluated for H. pylori infection (controls, group 2). Pertinent clinical data were obtained from the patients’ records. An experienced pathologist assessed the biopsies for the presence and grade of inflammation, activity, glandular atrophy, intestinal metaplasia, presence and density of H. pylori and presence of lymphoid follicles or aggregates. Results: NG was identified in 67 (3.1%) patients. On histological examination, group 1 had a significantly higher grade of gastritis (p < 0.001). The presence and density of H. pylori infection was significantly higher in group 1 (p < 0.001). The H. pylori density correlated significantly with the severity of gastritis (r = 0.57, p < 0.001). The endoscopic performance of NG on H. pylori infection had high specificity (96.8%) and positive predictive value (93.3%). Conclusion: This study outlined the clinicopathological features of NG identified among a cohort of dyspeptic patients in Kuwait and confirmed the close association with H. pylori infection. However, our study has a limitation in that histopathologic assessment of all NG patients was not feasible.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Endoscopic Nodular Gastritis in Dyspeptic Adults: Prevalence and Association with <i>Helicobacter pylori</i> Infection

Alenezi¹,

Alsurayei²,

Aly

et al. 2009

Med Princ Pract

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“…Nodular gastritis, however, is characterized endoscopically by micronodules with a smooth surface and is associated with pediatric patients with H. pylori infection (4,34). It would be clinically desirable to diagnose H. pylori-associated gastritis simply by endoscopic examination without gastric biopsy.…”

Section: Discussionmentioning

confidence: 99%

“…A number of reports have shown microscopic improvement of gastric mucosa after H. pylori eradication; for example, chronic active gastritis, atrophic gastritis, nodular gastritis, and intestinal metaplasia (IM) were diminished by eradication (3,4). In addition, eradication of H. pylori led to a lower prevalence rate of secondary gastric carcinoma in patients with multiple gastric carcinomas at different time points (5,6) and reduction of gastric mucosa-associated lymphoid tissue (MALT) lymphoma (7)(8)(9)(10).…”

Section: Introductionmentioning

confidence: 99%

Low-dose Aspirin Delays Gastric Healing after Helicobacter pylori Eradication

et al. 2011

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Background and Aim Helicobacter pylori (H. pylori) and aspirin are the major causes of gastric injury, and eradication of H. pylori can restore mucosal injury such as gastric ulcer. The aim of the present study was to investigate the effects of low-dose aspirin on the healing process, determined by endoscopic features, after H. pylori eradication. Methods From 2001 to 2008, 12,887 patients underwent endoscopic examination at our hospital. From these, 100 patients with and 100 patients without H. pylori infection were analyzed to identify the endoscopic features characteristic of H. pylori-infected stomach. Based on these characteristic features, we observed the healing process of 89 patients not taking low-dose aspirin and 12 patients taking low-dose aspirin for 6 months, 1 year, and 5 years, which was successful in eradicating H. pylori. Results Diffuse redness (DR) of the fundic mucosa was the characteristic feature of H. pylori-infected stomach, whereas reddish streaks (RS) on the greater curvature of the antrum was the characteristic finding in non-infected stomach. In the no aspirin group, DR faded by 6 months and new expression of RS was observed 1 year after H. pylori eradication. In contrast, in the aspirin group, both fading of DR and the expression of RS were observed 5 years after eradication. Conclusion Low-dose aspirin delayed the early phase of the healing process in the gastric mucosa after H. pylori eradication.

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Helicobacter pylorieradication improved the Kyoto classification score on endoscopy

et al. 2020

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Background and Aim: Endoscopy-based Kyoto classification predicts the risk of Helicobacter pylori infection and gastric cancer; however, the change in score following H. pylori eradication remains unknown. We retrospectively compared the Kyoto score before and after H. pylori eradication. Methods: H. pylori-positive patients who underwent baseline esophagogastroduodenoscopy (EGD), successful H. pylori eradication, and surveillance EGD were enrolled. The Kyoto score is a sum of scores for atrophy (Kimura-Takemoto atrophicborder classification none or C1: 0, C-II or C-III: 1

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Endoscopic Patterns and Histopathological Features after Eradication Therapy in Helicobacter pylori-Associated Nodular Gastritis

Cited by 15 publications

References 15 publications

Endoscopic Nodular Gastritis in Dyspeptic Adults: Prevalence and Association with <i>Helicobacter pylori</i> Infection

Endoscopic Nodular Gastritis in Dyspeptic Adults: Prevalence and Association with <i>Helicobacter pylori</i> Infection

Low-dose Aspirin Delays Gastric Healing after Helicobacter pylori Eradication

Helicobacter pylorieradication improved the Kyoto classification score on endoscopy

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