Endoscopic OCT with forward‐looking probe: clinical studies in urology and gastroenterology

Zagaynova, Elena V.; Gladkova, Natalia D.; Shakhova, Natalia M.; Gelikonov, Grigory V.; Gelikonov, Valentin M.

doi:10.1002/jbio.200710017

Cited by 75 publications

(68 citation statements)

References 47 publications

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“…22 If, during the imaging phase, loss of contact due to peristaltic relaxation was observed in the OCT image displayed in real-time, the catheter operator was instructed to stop the capsule by holding the tether at the incisors. The subject was then asked to dry swallow or sip water to reengage peristalsis.…”

Section: Tethered Capsule Endomicroscopy Imaging Proceduresmentioning

confidence: 99%

“…The capsule implements a second-generation form of optical coherence tomography (OCT) 14,15 named optical frequency domain imaging 16 or swept source OCT, [17][18][19] capable of collecting microscopic (10-μm axial resolution) crosssectional images of the esophagus. [20][21][22][23][24][25] The device comprises an 11 mm (diameter) ×24.8 mm (length) capsule connected to a flexible, 0.96-mm-diameter sheath, which serves as a tether (Fig. 1).…”

Section: Introductionmentioning

confidence: 99%

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Tethered capsule endomicroscopy: from bench to bedside at a primary care practice

et al. 2016

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Abstract. Due to the relatively high cost and inconvenience of upper endoscopic biopsy and the rising incidence of esophageal adenocarcinoma, there is currently a need for an improved method for screening for Barrett's esophagus. Ideally, such a test would be applied in the primary care setting and patients referred to endoscopy if the result is suspicious for Barrett's. Tethered capsule endomicroscopy (TCE) is a recently developed technology that rapidly acquires microscopic images of the entire esophagus in unsedated subjects. Here, we present our first experience with clinical translation and feasibility of TCE in a primary care practice. The acceptance of the TCE device by the primary care clinical staff and patients shows the potential of this device to be useful as a screening tool for a broader population.

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Section: Tethered Capsule Endomicroscopy Imaging Proceduresmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Tethered capsule endomicroscopy: from bench to bedside at a primary care practice

et al. 2016

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“…This system achieved a 2.2-mm-diam flexible OCT probe. This design is still used in current research, 17,18 and there have been modifications to the mechanism of fiber scanning, including using electroactive polymers, 19 piezoactuators, 20, 21 thermoelectric actuators, 22 magnetic actuators, 23 and resonant scanning. 24,25 Other methods of forward scanning include counter-rotating GRIN lenses, 26,27 which have the smallest diameter at 1.65 mm, and MEMS 1-D 22, 28-30 and 2-D scanning.…”

Section: Introductionmentioning

confidence: 99%

Design of a handheld optical coherence microscopy endoscope

2011

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Abstract. Optical coherence microscopy (OCM) combines coherence gating, high numerical aperture optics, and a fiber-core pinhole to provide high axial and lateral resolution with relatively large depth of imaging. We present a handheld rigid OCM endoscope designed for small animal surgical imaging, with a 6-mm diam tip, 1-mm scan width, and 1-mm imaging depth. X-Y scanning is performed distally with mirrors mounted to micro galvonometer scanners incorporated into the endoscope handle. The endoscope optical design consists of scanning doublets, an afocal Hopkins relay lens system, a 0.4 numerical aperture water immersion objective, and a cover glass. This endoscope can resolve laterally a 1.4-μm line pair feature and has an axial resolution (full width half maximum) of 5.4 μm. Images taken with this endoscope of fresh ex-vivo mouse ovaries show structural features, such as corpus luteum, primary follicles, growing follicles, and fallopian tubes. This rigid handheld OCM endoscope can be useful for a variety of minimally invasive and surgical imaging applications. C 2011 Society of Photo-Optical Instrumentation Engineers (SPIE).

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“…In current clinical practice, intraoperative OCT systems can be inbuilt in operating microscopes [15] and endoscopic instruments [16,17]. However, the criteria for tumorous and nontumorous brain tissue differentiation along the margin of tumor resection are still not fully developed.…”

Section: сLinical Medicinementioning

confidence: 99%

Cross-Polarization Optical Coherence Tomography in Comparative in vivo and ex vivo Studies of the Optical Properties of Normal and Tumorous Brain Tissues

Kiseleva¹,

Yashin²,

Моисеев³

et al. 2017

Sovrem Tehnol Med

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The aim of the study was to provide visual and quantitative evaluation of normal and tumorous brain tissue images obtained by crosspolarization optical coherence tomography (CP OCT) in comparative in vivo and ex vivo studies.Materials and Methods. The study was conducted using CP OCT -a non-damaging optical method of tissue structure imaging, which is capable of obtaining real time 3D images 2.4×2.4×1.25 mm in size within a short time of 26 s. The object of the study were normal and tumorous brain tissues of 12 experimental rats of a Wistar line: 4 -intact, 4 -with an induced malignant 101.8-glioma model and 4 -with an induced malignant C6-glioma model. In the intact rats, the cortex and the white matter were studied, in the rats with tumors -the central part of the tumor on the cortical surface, first in vivo and then ex vivo. Quantitative data evaluation of the CP OCT images involved calculation of attenuation coefficients for each tissue type.Results. A comparative qualitative image analysis of normal brain tissues and gliomas showed that the CP OCT images obtained ex vivo have the intensity and the attenuation rate (in both the initial and orthogonal polarizations) greater than those obtained in vivo. Quantitative analysis of the CP OCT images revealed significant statistical differences (p<0.02) between the attenuation coefficients from both tumors and the white matter in vivo (5. A comparison of the attenuation coefficients between the cortex and the white matter of the normal brain, as well as the white matter in the normal and malignant tissues, showed significant statistical differences both in vivo and ex vivo.Conclusion. The results of a qualitative comparative analysis of optical properties of normal and tumorous brain tissues using CP OCT allow us to conclude that the images obtained ex vivo show a full qualitative similarity with the structures observed with the intravital CP OCT study. Quantitative evaluation of CP OCT signals demonstrated a significant difference in the attenuation coefficient (p<0.005) between tumorous tissue, on the one hand, and normal white matter, on the other, both ex vivo and in vivo. However, when optical coefficients of tissues are evaluated in vivo, it is necessary to introduce adjustments based on the known differences between ex vivo and in vivo attenuation coefficients.

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Endoscopic OCT with forward‐looking probe: clinical studies in urology and gastroenterology

Cited by 75 publications

References 47 publications

Tethered capsule endomicroscopy: from bench to bedside at a primary care practice

Tethered capsule endomicroscopy: from bench to bedside at a primary care practice

Design of a handheld optical coherence microscopy endoscope

Cross-Polarization Optical Coherence Tomography in Comparative in vivo and ex vivo Studies of the Optical Properties of Normal and Tumorous Brain Tissues

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