Endoscopic monitoring of Crohn's disease treatment: A prospective, randomized clinical trial

Landi, Bruno; Do, Tram Anh; Cortot, Antoine; Soulé, Jean–Claude; René, E; Jp, Gendre; Bories, P; See, Anna; Metman, E.; Florent, C; Lerebours, Éric; Mary, Jean‐Yves; Modigliani, R

doi:10.1016/0016-5085(92)91725-j

Cited by 252 publications

(104 citation statements)

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“…The GETAID group has repeatedly shown that endoscopic activity of Crohn's disease correlates either poorly or not at all with a clinical disease activity index 6,7,29 . Similarly in ulcerative colitis, macroscopic changes at colonoscopy have correlated poorly with the PT clinical index, so an objective measure of inflammation is not necessarily reflective of a patient's symptoms 30 .…”

Section: Discussionmentioning

confidence: 99%

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The Manitoba IBD Index: Evidence for a New and Simple Indicator of IBD Activity

et al. 2009

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Section: Discussionmentioning

confidence: 99%

“…Imaging modalities have also been used to assess disease activity. This approach avoids the subjective element of symptom inquiry, but it correlates poorly with active symptoms and it is problematic to repeat imaging, endoscopic or radiological methods for sequential assessment of activity 6,7 .…”

Section: Formentioning

confidence: 99%

The Manitoba IBD Index: Evidence for a New and Simple Indicator of IBD Activity

et al. 2009

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“…The current gold standard diagnostic test is endoscopy, since with this technique even early mucosal changes can be visualized and the extent and severity of disease can be assessed accurately. Consequently, endoscopy (with mucosal biopsy sampling) is generally used to establish a diagnosis in CD and is routinely used to monitor treatment (1,2). However, endoscopy is associated with unpleasant bowel preparation, discomfort during the endoscopic procedure, the risk of procedure-related complications, and a relatively high cost (3).…”

mentioning

confidence: 99%

Feasibility of evaluating Crohn's disease activity at 3.0 Tesla

Gemert-Horsthuis

Florie

Hommes

et al. 2006

Magnetic Resonance Imaging

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Purpose: To determine whether abdominal 3.0T MRI can be used for evaluation of Crohn's disease (CD) compared with ileocolonoscopy (CS), and to determine patient preference for MRI as opposed to CS. Materials and Methods:Twenty patients scheduled for CS underwent MRI. At CS, disease severity was graded and the Crohn's Disease Endoscopic Index of Severity (CDEIS) was determined. Radiological grading (by two observers) was compared with endoscopic grading and CDEIS. Patient experience and preference were determined. Results:In respectively 10 (observer 1) and 13 patients (observer 2) exact agreement between radiological and endoscopic grading was found. In respectively 10 and 7 patients radiological and endoscopic grading differed one level. No statistically significant correlation was found between radiological grading and CDEIS. Between bowel wall thickness and CDEIS weak to moderate correlations were found, and between bowel wall enhancement and CDEIS weak correlations were found. All patients preferred MRI over CS. Conclusion:It is feasible to perform abdominal 3.0T MRI using orally administered contrast medium for evaluation of CD, and this method can be considered a patient-friendly alternative to CS.

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“…Since the 60s, in fact, clinical studies suggested that the long-term outcome after a steroid course was more favorable in UC patients who achieved both clinical and endoscopic remission compared with those who achieved only clinical remission [1]. Conversely, observational studies failed to report a clear impact of healing of mucosal lesions on relapse rate in CD patients with corticosteroidinduced remission [2]. These observations led clinicians to limit their CD treatment only on symptomatic remission.…”

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confidence: 99%