Endoscopic micro-optical coherence tomography with extended depth of focus using a binary phase spatial filter

Kim, Junyoung; Xing, Jingchao; Nam, Hyunwoo; Song, Joon Woo; Kim, Jin Won; Yoo, Hongki

doi:10.1364/ol.42.000379

Cited by 51 publications

(27 citation statements)

References 20 publications

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“…The common‐path probe with apodization design adopted can extend DOF moderately while maintain the high transverse resolution . Further improvement in lateral resolution requires DOF extension techniques such as phase modulation for producing quasi‐Bessel beams through a cylindrical waveguide or a phase mask . Our further study will focus on endoscopic μOCT probe with higher extended DOF without the compromise of high resolution for clinical application.…”

Section: Resultsmentioning

confidence: 99%

Endomicroscopic optical coherence tomography for cellular resolution imaging of gastrointestinal tracts

Luo

Cui

et al. 2017

Journal of Biophotonics

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Our ability to detect neoplastic changes in gastrointestinal (GI) tracts is limited by the lack of an endomicroscopic imaging tool that provides cellular-level structural details of GI mucosa over a large tissue area. In this article, we report a fiber-optic-based micro-optical coherence tomography (μOCT) system and demonstrate its capability to acquire cellular-level details of GI tissue through circumferential scanning. The system achieves an axial resolution of 2.48 μm in air and a transverse resolution of 4.8 μm with a depth-of-focus (DOF) of ~150 μm. To mitigate the issue of limited DOF, we used a rigid sheath to maintain a circular lumen and center the distal-end optics. The sensitivity is tested to be 98.8 dB with an illumination power of 15.6 mW on the sample. With fresh swine colon tissues imaged ex vivo, detailed structures such as crypt lumens and goblet cells can be clearly resolved, demonstrating that this fiber-optic μOCT system is capable of visualizing cellular-level morphological features. We also demonstrate that time-lapsed frame averaging and imaging speckle reduction are essential for clearly visualizing cellular-level details. Further development of a clinically viable μOCT endomicroscope is likely to improve the diagnostic outcome of GI cancers.

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Section: Resultsmentioning

confidence: 99%

Endomicroscopic optical coherence tomography for cellular resolution imaging of gastrointestinal tracts

Luo

Cui

et al. 2017

Journal of Biophotonics

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“…OCT was designed based on coherence interferometry [67,68], which obtains images from under-the-surface tissue structures [69,70]. New OCT tools with ultra-high image resolution have been demonstrated [71][72][73][74][75][76][77]. Shorter wavelengths with broader-bandwidth light sources potentially improve image resolution.…”

Section: Metalens-based Endoscopic Optical Coherence Tomography (Oct)mentioning

confidence: 99%

Optical MEMS

2019

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published over 300 technical papers and 11 book chapters and holds 31 US patents. His current research interests include MEMS/NEMS, inertial sensors, microactuators, optical MEMS, optical beam steering, LiDAR, microspectrometers, and optical microendoscopy. He is a fellow of IEEE and SPIE. Frederic Zamkotsian received the Ph.D. degree in Physics in 1993 from the University of Marseilles (France). Since then, he has worked in the field of optoelectronics and semiconductor physics for optical telecommunication in France and in Japan. In 1998, he joined the Laboratoire d'Astrophysique de Marseille (LAM, Aix-Marseille University, CNRS, CNES), where he is involved in MOEMS-based astronomical instrumentation for ground-based and space telescopes, including conception and characterization of new MOEMS devices, as well as development of new instruments (principal investigator of BATMAN instrument to be placed on 4 m class telescope in 2020 and on 8 m class telescope in 2023). He has published over 200 technical papers and international conference proceedings, as well as 3 book chapters. On MOEMS, his current research interests are in programmable slits for application in multiobject spectroscopy (JWST, European networks, EUCLID, BATMAN), deformable mirrors for adaptive optics, and programmable gratings for spectral tailoring. vii micromachines EditorialOptical micro-electro-mechanical systems (MEMS), micro-opto-electro-mechanical systems (MOEMS), or optical microsystems are devices or systems that interact with light through actuation or sensing at a micron or millimeter scale. Optical MEMS have had enormous commercial success in projectors, displays, and fiber optic communications. The best known example is Texas Instruments' digital micromirror devices (DMDs). The development of optical MEMS was impeded seriously by the Telecom Bubble in 2000. Fortunately, DMDs grew their market size even in that economy downturn. Meanwhile, in the last one and half decades, the optical MEMS market has been slowly but steadily recovering. During this time span, the major technological change was the shift of thin-film polysilicon microstructures to single-crystal-silicon microstructures. Especially in the last few years, cloud data centers demand large-port optical cross connects (OXCs), autonomous driving looks for miniature light detection and ranging systems (LiDAR), and virtual reality/augmented reality (VR/AR) demands tiny optical scanners. This is a new wave of opportunities for optical MEMS. Furthermore, several research institutes around the world have been developing MOEMS devices for extreme applications (very fine tailoring of light beam in terms of phase, intensity, or wavelength) and/or extreme environments (high vacuum or cryogenic temperature) for many years.This special issue contains twelve research papers covering MEMS mirrors [1-10], MEMS variable optical attenuators (VOAs) [11], and tunable spectral filters [12]. These MEMS devices are based on three of the commonly used actuation mechanisms: electrothermal [1], ele...

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“…The common-path probe with apodization design adopted can extend the DOF moderately while maintaining the high transverse resolution [25,73]. Further improvement in transverse resolution requires DOF extension techniques such as phase modulation for producing quasi-Bessel beams through a cylindrical waveguide or a phase mask [75,139]. Our further study will focus on endoscopic µOCT probe with higher extended DOF without the compromise of high resolution for clinical application.…”

Section: Discussionmentioning

confidence: 99%

“…OCT first proposed for the ophthalmic application by Fujimoto et al [19] is a non-invasive imaging tool, enabling in situ and real-time visualization of microscopic volumetric morphology without tissue removal. To date, OCT is not only commercially employed in ophthalmic imaging [69,70], but also increasingly used in dermatological imaging [71,72], airway function evaluation [73,74], gastrointestinal tract imaging [48,75] and cardiovascular disease diagnosis [25,66,67].…”

Section: Background and Development Of Octmentioning

confidence: 99%

“…Endoscopic OCT is a procedure that applied to visualize the surfaces of internal organs by inserting a miniature probe into the body, and various endoscopic OCT systems with different designed probe have been published [87,88]. For application, it has widely used for airway function evaluation [73,74], gastrointestinal tract imaging [50,75], cardiovascular disease diagnosis [25,66,67], urological application [89,90], neurological application [91][92][93], nasal imaging [94] and so on.…”

Section: Endoscopic Oct Probementioning

confidence: 99%

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Cellular-resolution endoscopic optical coherence tomography and image analytics

Luo¹

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First of all, I wish to express my greatest gratitude to my supervisor, Professor Linbo Liu, for his selfless instruction and guidance throughout my entire PhD study. He provides a wonderful research platform, gives a great of advice and recommendation and encourages me to explore challenging and exciting research projects. I have really benefited a lot on research methods and directions from every discussion and meeting with him. I would like to thank Professor Perry Ping Shum for his wise advices during my PhD period, which are also useful for my future life. He is brilliant and erudite, and encourages me to keep self-improvement. I appreciate the unconditional help of Dr. Dongyao Cui for her kind advices and suggestions. We have many deep discussions not only on various research problems, but also on what the person we want to be. I am thankful for all the collaboration with the fellow students, researchers and staffs in Fiber Technology Lab at Nanyang Technological University. I also thank my friends in Singapore, who accompanied me throughout my PhD study. I also appreciate the joyful time that I have spent with the friends in fitness, running, riding, hiking and playing badminton. Last but not least, I would like to thank my husband Zhenghua Chen for his very supportive trust. He listens closely to me when I feel confused and encourages me to try my best to do what I want to do. I am very lucky that I have met him in my life. I must also thank my beloved parents and sister. They supported me in every aspect and understood me without any doubt. They always give their best to me without hesitation. I love you all! i

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Endoscopic micro-optical coherence tomography with extended depth of focus using a binary phase spatial filter

Cited by 51 publications

References 20 publications

Endomicroscopic optical coherence tomography for cellular resolution imaging of gastrointestinal tracts

Endomicroscopic optical coherence tomography for cellular resolution imaging of gastrointestinal tracts

Optical MEMS

Cellular-resolution endoscopic optical coherence tomography and image analytics

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