Abstract:Between June 1983 and December 2002, 32 patients were treated for primary localized laryngo-tracheobronchial amyloidosis (LTBA) at our institution. For enrollment in this retrospective study, at least one positive biopsy with Congo red stain and a diagnostic test battery excluding systemic or secondary amyloidosis were mandatory. The most common presenting symptom was dyspnea, which was observed in 75% of cases. Endoscopic appearance was described as submucosal plaques and nodules with a cobblestone appearance… Show more
“…Amyloid goiter may also be seen in secondary amyloidosis (AA) [24]. Amyloidosis of the tracheobronchial tree and larynx [25], although a potentially serious condition, is not a component of a systemic amyloidosis syndrome. The finding of amyloid deposits in the cardiac atria [26], pleura, and articular cartilage [27,28] may also represent localized amyloid, and additional evidence of visceral involvement is required before systemic amyloidosis is diagnosed.…”
Section: Differentiating Systemic From Localized Amyloidosismentioning
“…Amyloid goiter may also be seen in secondary amyloidosis (AA) [24]. Amyloidosis of the tracheobronchial tree and larynx [25], although a potentially serious condition, is not a component of a systemic amyloidosis syndrome. The finding of amyloid deposits in the cardiac atria [26], pleura, and articular cartilage [27,28] may also represent localized amyloid, and additional evidence of visceral involvement is required before systemic amyloidosis is diagnosed.…”
Section: Differentiating Systemic From Localized Amyloidosismentioning
“…Tracheobronchial amyloidosis was associated with TBO in 22% in one series. (Piazza et al, 2003) Ultimately, the diagnosis of pulmonary amyloidosis requires histologic confirmation. An excellent overview of the pathologic features of pulmonary amyloidosis has been published.…”
“…In a retrospective series of 32 patients over 19 years, sixteen had persistent asymptomatic endolumenal disease. (Piazza et al, 2003) Two patients had endolumenal procedures with subsequent requirement of surgical resection. Each patient had no evidence of recurrent endolumenal amyloid after 5 to 8 years.…”
“…In a pseudotumor mass or a circumferential wall thickening, mechanical resection and/or dilatation coupled with transmucosal Nd:YAG laser treatment with low power and high energy density are recommended. On the other hand, submucosal plaques, particularly when located at the glottic or subglottic levels, should be treated by a mucosa-sparing approach or by CO 2 laser, thus minimizing scar tissue formation and subsequent complications (Piazza et al, 2003). Localized laryngeal amyloidosis is a slowly progressive disease that should be treated according to the complaints of the patient.…”
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