Endoscopic Management of Benign Esophageal Stricture of Multifactorial Etiology Complicated by Esophageal Perforation

Golikov, Edwin; Babayants, Yuriy; Sheinman, Marc; Salem, Suhail

doi:10.14309/00000434-201710001-01738

Cited by 1 publication

(2 citation statements)

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“…Along with the requirement for repeat treatments, endoscopic balloon dilation is associated with a high recurrence rate (66–100%) and an increased risk of esophageal perforation (1%). [ 2,4,5 ] While SEMS placement provides adequate support for maintaining esophageal patency, it could encounter the same complications. This is because the stent exerts persistent mechanical pressure on the esophageal wall, resulting in hyperplasia and restenosis of the stent‐induced tissue over time.…”

Section: Introductionmentioning

confidence: 99%

“…Esophageal stricture is a critical clinical problem that can have a single cause or multifactorial causes such as developmental, inflammatory, neuromuscular, and iatrogenic. [1,2] The most often used treatment option for esophageal strictures is endoscopic balloon dilatation, followed by the implantation of a self-expanding Figure 1. Scheme illustrations and design for polymer-free drug-eluting stents (DESs).…”

Section: Introductionmentioning

confidence: 99%

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Flexible 3D Nanonetworked Silica Film as a Polymer‐Free Drug‐Eluting Stent Platform to Effectively Suppress Tissue Hyperplasia in Rat Esophagus

Jeon

Kang

Bae

et al. 2022

Adv Healthcare Materials

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Loading and eluting drugs on self‐expandable metallic stents (SEMSs) can be challenging in terms of fabrication, mechanical stability, and therapeutic effects. In this study, a flexible 3D nanonetworked silica film (NSF) capable of withstanding mechanical stress during dynamic expansion is constructed to function as a drug delivery platform on an entire SEMS surface. Despite covering a broad curved area, the synthesized NSF is defect‐free and thin enough to increase the stent strut diameter (110 µm) by only 0.4 percent (110.45 µm). The hydrophobic modification of the surface enables loading of 4.7 times the sirolimus (SRL) concentration in NSF than Cypher, polymer‐coated commercial stent, which is based on the same thickness of coating layer. Furthermore, SRL‐loaded NSF exhibits a twofold delay in release compared to the control group without NSF. The SRL‐loaded NSF SEMS significantly suppresses stent‐induced tissue hyperplasia than the control SEMS in the rat esophagus (all variables, p < 0.05). Thus, the developed NSF is a promising polymer‐free drug delivery platform to efficiently treat esophageal stricture.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%