Endoscopic Laser Therapy for Gastrointestinal Disease

Fleischer, David E.

doi:10.1001/archinte.1984.00350180161022

Cited by 20 publications

(2 citation statements)

References 16 publications

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“…Third, the laser wavelength was 1.5 μm, corresponding to an optical penetration depth of >0.57 mm in water [15], and the laser was operated in CW mode. On the other hand, various laser wavelengths such as 514, 532, 810, and 1064 nm were used in Barrett's esophagus treatment studies [29][30][31], providing a relatively deep optical penetration depth in water. Thus, the study can be extended by considering different laser wavelengths and pulsed laser modes.…”

Section: Discussionmentioning

confidence: 99%

An endoscopic approach providing near‐infrared laser‐induced coagulation with accurate depth limits

Turker‐Burhan,

Ellidokuz,

Bagriyanik

et al. 2024

Journal of Biophotonics

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This article investigates an endoscopic approach that utilizes negative pressure to achieve laser‐induced thermal coagulation limited to the esophageal wall's mucosal and superficial submucosal layers. The study was built upon a series of studies combining numerical simulation based on the Monte‐Carlo technique and ex vivo porcine tissue experiments, including apparatus design and histology analysis. An endoscopy apparatus was developed using 3D printing to validate the tissue stretching‐based approach. A fiber‐pigtailed diode was used as the near‐infrared source, emitting 208.8 W/cm2 laser irradiance at 1.5 μm. Simulation results suggested that the approach successfully created a local heat well to prevent residual thermal effects (>65°C) from penetrating the deeper submucosal layer. Histology analysis of ex vivo tissues showed that at a fluence of 5.22 kJ/cm2, the depth of thermal coagulation was reduced by half compared to the control. With further preclinical studies, including endoscopy apparatus design, the approach can be applied to the larger esophageal surface.

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Section: Discussionmentioning

confidence: 99%

An endoscopic approach providing near‐infrared laser‐induced coagulation with accurate depth limits

Turker‐Burhan,

Ellidokuz,

Bagriyanik

et al. 2024

Journal of Biophotonics

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“…Laser-induced thermal therapy, whose coagulation parameters are relatively controllable, may re-emerge to minimize acute side effects such as bleeding, perforation, and organ narrowing in the treatment of superficial esophageal abnormal tissues 1,2 . In particular, recent developments in fiber optics, diode laser technology, and optical imaging modalities reinforce this prediction 3 .…”

Section: Introductionmentioning

confidence: 99%

Predicting dark-field images of H and E-stained esophageal specimens

Arli,

Dinc,

Turker Burhan

et al. 2023

Advances in Microscopic Imaging IV

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The potential of laser-induced thermal therapy can be reassessed in treating abnormal mucosal tissues with advances in fiber optics, diode laser technology, and optical imaging modalities. In this context, studies optimizing a large parameter matrix (e.g., laser power, surface scanning speed, beam diameter, and irradiation duration) may be of interest. This study presents an artificial intelligence algorithm utilizing a generative adversarial network that predicts dark-field microscopy images from bright-field images of H&E-stained esophageal specimens. The calculated structural similarity index measurement between ground truth and the predicted dark-field image reaches an average of 74%. Also, the mean squared error is 0.7%.

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Lasers in Medicine

Gelb¹

1985

Arch Intern Med

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Endoscopic Laser Therapy for Gastrointestinal Disease

Cited by 20 publications

References 16 publications

An endoscopic approach providing near‐infrared laser‐induced coagulation with accurate depth limits

An endoscopic approach providing near‐infrared laser‐induced coagulation with accurate depth limits

Predicting dark-field images of H and E-stained esophageal specimens

Lasers in Medicine

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