Endoscopic full thickness resection vs. transanal endoscopic microsurgery for local treatment of rectal neuroendocrine tumors - a retrospective analysis

Brand, Markus; Reimer, Stanislaus; Reibetanz, J.; Flemming, Sven; Kornmann, Marko; Meining, Alexander

doi:10.1007/s00384-020-03800-x

Cited by 27 publications

(23 citation statements)

References 20 publications

(45 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…EFTR is performed using a full thickness resection device (FTRD), that is an over-the-scope system, which allows a single step EFTR after placement of a modified over-the-scope-clip (OTSC). Limitations correlated with this technique are the resectable tumor size, due to diameter of the FTRD (<20 mm, but this is not a strong limitation because rectal NETs >20 mm are referred to surgery), but EFTR appears to be an effective and safe resection method for well-differentiated rectal NETs of smaller size; combining a high complete resection rate with low complication rate and short procedure time [ 57 ].…”

Section: Management Of Rectal Netsmentioning

confidence: 99%

Diagnosis and Management of Rectal Neuroendocrine Tumors (NETs)

et al. 2021

View full text Add to dashboard Cite

Rectal neuroendocrine tumors (NETs) are rare, with an incidence of 0.17%, but they represent 12% to 27% of all NETs and 20% of gastrointestinal NETs. Although rectal NETs are uncommon tumors, their incidence has increased over the past few years, and this is probably due to the improvement in detection rates made by advanced endoscopic procedures. The biological behavior of rectal NETs may be different: factors predicting the risk of metastases have been identified, such as size and grade of differentiation. The tendency for metastatic diffusion generally depends on the tumor size, muscular and lymphovascular infiltration, and histopathological differentiation. According to the current European Neuroendocrine Tumor Society (ENETS) guidelines, tumors that are smaller than 10 mm and well differentiated are thought to have a low risk of lymphovascular invasion, and they should be completely removed endoscopically. Rectal NETs larger than 20 mm have a higher risk of involvement of muscularis propria and high metastatic risk and are candidates for surgical resection. There is controversy over rectal NETs of intermediate size, 10–19 mm, where the metastatic risk is considered to be 10–15%: assessment of tumors endoscopically and by endoanal ultrasound should guide treatment in these cases towards endoscopic, transanal, or surgical resection.

show abstract

Section: Management Of Rectal Netsmentioning

confidence: 99%

Diagnosis and Management of Rectal Neuroendocrine Tumors (NETs)

et al. 2021

View full text Add to dashboard Cite

show abstract

“…In addition, EFTR with a full-thickness resection device (FTRD; Ovesco Endoscopy, Tübingen, Germany) is a novel and feasible method for resection of mucosal and submucosal lesions in Western countries. 38,40 Its operating steps are different from the 2 endoscopic methods introduced in our study, and our 2 methods create artificial perforations. FTRD can complete closure of the wall by applying an over-the-scope clip before snare excision and reduce AEs, especially perforation.…”

Section: Discussionmentioning

confidence: 93%

Comparison of endoscopic full-thickness resection and cap-assisted endoscopic full-thickness resection in the treatment of small (≤1.5 cm) gastric GI stromal tumors

Yang

Jiang

et al. 2022

Gastrointestinal Endoscopy

View full text Add to dashboard Cite

“…In the preoperative staging of distant metastasis, dual modality PET is not used as routine examination, which may result in an underestimation of tumor stage. Along with the development and application of new methods achieving satisfactory results in treating RNET, such as TAMIS [ 6 ] and endoscopic full thickness resection (eFTR) [ 28 ], more studies remain to be conducted for further investigation.…”

Section: Discussionmentioning

confidence: 99%

Long-term outcomes of transanal endoscopic microsurgery for the treatment of rectal neuroendocrine tumors

Shi

Hou

et al. 2022

BMC Surg

View full text Add to dashboard Cite

Background Transanal endoscopic microsurgery (TEM) has been accepted worldwide for the treatment of local rectal lesions. We aimed to assess the efficacy and safety of TEM in the treatment of rectal neuroendocrine tumors (RNET). Methods A retrospective study of patients who had undergone TEM for RNET at our institution between December 2006 and June 2019 was performed. Demographic and tumor characteristics, operative and pathological details, complications, anal function questionnaires, and follow-up data were included. Results A total of 144 patients was included. TEM was performed as primary excision in 54 patients, after endoscopic forceps biopsy in 57 patients, and after incomplete resection by endoscopic excision in 33 patients. The median size of all primary tumors was 0.6 cm (range, 0.3–2.0 cm), and the negative resection margin was achieved in 142 (98.6%) patients. Postoperative complications (referring to only bleeding) occurred in 3 (2.1%) patients and was successfully managed with conservative method. After a median follow-up of 75.5 months after surgery, 3 patients died of other causes, and 2 patients suffered metastasis. An anal function questionnaire was posted 24 months after TEM. Among the results, 3 (2.1%) patients complained of major low anterior resection syndrome (LARS), including 1 (0.7%) who suffered from complete incontinence, while 6 (4.2%) patients had minor LARS. Conclusions TEM has satisfying long-term outcomes and relatively low anal function disturbance as for the treatment of small RNET. TEM also acts as a preferred salvage treatment for incomplete endoscopic excision.

show abstract

Endoscopic full thickness resection vs. transanal endoscopic microsurgery for local treatment of rectal neuroendocrine tumors - a retrospective analysis

Cited by 27 publications

References 20 publications

Diagnosis and Management of Rectal Neuroendocrine Tumors (NETs)

Diagnosis and Management of Rectal Neuroendocrine Tumors (NETs)

Comparison of endoscopic full-thickness resection and cap-assisted endoscopic full-thickness resection in the treatment of small (≤1.5 cm) gastric GI stromal tumors

Long-term outcomes of transanal endoscopic microsurgery for the treatment of rectal neuroendocrine tumors

Contact Info

Product

Resources

About