To evaluate the reliability of drug induced sleep endoscopy (DISE) in identifying levels and degrees of severity of obstruction in sleep disordered breathing (SDB) patients. Patients with obstructive sleep apnea syndrome (OSAS) and habitual snoring diagnosed by polysomnography assessed by history and Epworth Sleepiness Scale (ESS), modified Malampatti index, Friedman staging system, Assessment of the Body mass index (BMI), neck circumference (NC), Müller maneuver (MM) and DISE using the NOHL (nose, oropharynx, hypopharynx and larynx) classification system. Our results revealed 66 patients, 34 males and 32 females with ages ranging from 23 to 58 years. BMI showed that 86.4 % of cases were obese with mean BMI (35.1 ± 5.6) ranging from (24 -50 kg/m 2 ). NC showed large NC (> 37cm) in 100 % of females while it was large (> 43 cm) in only 29.4 % of males. The mean apnea/hypopnea index was 10.7 ± (11.8/h). Obstruction at oropharyngeal level was 82% of the patients with grades ranging from 50 to 100%followed by obstruction at the level of hypopharynx in 68%. Only 13.6% showed supraglottic obstruction due to flappy epiglottis. Almost all patients showed multilevel obstruction with different grades. We found no correlation between the results of DISE, MM and classic ENT evaluation techniques. DISE treatment recommendations was different in 82% of patients at the oropharyngeal level and in 39% at the hypopharyngeal level than those of MM, but was nearly the same regarding supraglottic obstruction.Conclusion: DISE is a reliable tool of upper airway collapse assessment leading to better treatment recommendations for SDB patients.