Endoscopic evaluation of the effect of ketoprofen, ibuprofen and aspirin on the gastroduodenal mucosa

Bergmann, Jean‐François; Chassany, Olivier; Genève, Jean; Abiteboul, M; Caulin, C; Segrestaa, J. M.

doi:10.1007/bf00265938

Cited by 15 publications

(6 citation statements)

References 9 publications

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“…Bergmann et al [21] administered single-dose ketoprofen (25 mg), ibuprofen (200 mg) or aspirin (500 mg) to 12 healthy subjects with empty stomach and found that lesions were similar with ketoprofen and ibuprofen using the LS and they were less local toxic compared to aspirin. Previous publications support the finding of the local damaging effect of short-term, single-dose use of NSAIDs [15] .…”

Section: Discussionmentioning

confidence: 99%

Endoscopic and histopathological evaluation of acute gastric injury in high-dose acetaminophen and nonsteroidal anti-inflammatory drug ingestion with suicidal intent

Soylu¹,

Dolapcioglu²,

Dolay³

et al. 2008

WJG

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AIM:To evaluate endoscopic and histopathologic aspects of acute gastric injury due to ingestion of high-dose acetaminophen and nonsteroidal antiinflammatory drugs (NSAIDs) with respect to some risk factors and patient characteristics. METHODS:The study group consists of 50 patients admitted to emergency department with high dose analgesic ingestion (group Ⅰ) with suicidal intent. Thirty patients with or without mild complaints of dyspepsia (group Ⅱ) were selected as the control group. The study group was stratified according to the use of type and number of analgesics. Endoscopic findings were evaluated according to the Lanza score (LS), expressing the severity of the gastroduodenal damage and biopsies according to a scoring system based on histopathologic findings of acute erosive gastritis. RESULTS: Gastroduodenal damage was significantly more severe in group Ⅰ compared to group Ⅱ (P < 0.01). The LS was similar in both groups Ⅰa and Ⅰb. However LS was significantly higher in patients who had ingested multiple NSAIDs (group Ⅰc) compared to other patients (P < 0.01). The LS was correlated to age (P < 0.01) and total amount of drug ingested (P < 0.05) in group Ⅰ; but it was not correlated with Helicobacter pylori (H pylori) infection or duration of exposure (P > 0.05). The biopsy score (BS) was higher in group Ⅰ than group Ⅱ (P < 0.01), and higher in group Ⅰb than group Ⅰa (P < 0.05). CONCLUSION: The histopathologic damage was more severe among NSAID ingesting patients compared to those ingesting only acetaminophen and there is no significant difference in the endoscopic findings between the groups. There is no significant difference in the LS between the groups. This lack of significance is remarkable in terms of the gastric effects of highdose acetaminophen.

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Section: Discussionmentioning

confidence: 99%

Endoscopic and histopathological evaluation of acute gastric injury in high-dose acetaminophen and nonsteroidal anti-inflammatory drug ingestion with suicidal intent

Soylu¹,

Dolapcioglu²,

Dolay³

et al. 2008

WJG

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“…A number of studies have reported that prescription dosage level ibuprofen produces time and dose-dependent blood loss (assessed using the radiochromium blood loss technique) from the GI tract of volunteers or patients (Warrington et al 1982;Aabakken et al 1989;Hunt et al 2000) and mild-moderate endoscopic changes in fasted human volunteers (Lanza et al 1979(Lanza et al , 1981(Lanza et al , 1987Friedman et al 1990;Bergmann et al 1992;Roth et al 1993;Müller et al 1995;Gallego-Sandin et al 2004) or those with rheumatic diseases (Teixeira et al 1997). The extent of the loss of blood maybe overestimated using the radiochromium technique as a consequence of biliary excretion of the radiolabelled chromium (Schneider et al 1984;Rainsford 2004a).…”

Section: Gastro-intestinal (Gi) Toxicitymentioning

confidence: 97%

Ibuprofen: pharmacology, efficacy and safety

2009

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This assessment of the safety and benefits of ibuprofen can be summarized thus: (1) Ibuprofen at OTC doses has low possibilities of serious GI events, and little prospect of developing renal and associated CV events. Ibuprofen OTC does not represent a risk for developing liver injury especially the irreversible liver damage observed with paracetamol and the occasional liver reactions from aspirin. (2) The pharmacokinetic properties of ibuprofen, especially the short plasma half-life of elimination, lack of development of pathologically related metabolites (e.g. covalent modification of liver proteins by the quinine-imine metabolite of paracetamol or irreversible acetylation of biomolecules by aspirin) are support for the view that these pharmacokinetic and notably metabolic effects of ibuprofen favour its low toxic potential. (3) The multiple actions of ibuprofen in controlling inflammation combine with moderate inhibition of COX-1 and COX-2 and low residence time of the drug in the body may account for the low GI, CV and renal risks from ibuprofen, especially at OTC doses.

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“…Obviously, ketoprofen has a dual inhibitory effect to arachidonic acid (AA) . Furthermore, ketoprofen also can improve the respiratory and circulatory effects of endotoxic shock, stabilize lysosomal membranes against osmotic damage, and inhibit the release of lysosomal enzymes. , Unfortunately, it has been found that ketoprofen can induce gastrointestinal tract injuries, , acute renal failure in the oral route, and acute asthma when it is used as an adhesive agent in clinical practice. , In contrast, pulmonary administration of NSAIDs can avoid systemic exposure to the drugs and reduce its side effects. Stigliani et al developed the inhaled powder containing ketoprofen lysate to treat lung inflammation, effectively reducing the cytotoxic effect of drugs on bronchial epithelial cells .…”

Section: Introductionmentioning

confidence: 99%

Investigation of Drug for Pulmonary Administration–Model Pulmonary Surfactant Monolayer Interactions Using Langmuir–Blodgett Monolayer and Molecular Dynamics Simulation: A Case Study of Ketoprofen

Liu

et al. 2019

Langmuir

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Pulmonary administration is widely used for the treatment of lung diseases. The interaction between drug molecules and pulmonary surfactants affects the efficacy of the drug directly. The location and distribution of drug molecules in a model pulmonary surfactant monolayer under different surface pressures can provide vivid information on the interaction between drug molecules and pulmonary surfactants during the pulmonary administration. Ketoprofen is a nonsteroidal anti-inflammatory drug for pulmonary administration. The effect of ketoprofen molecules on the lipid monolayer containing 1,2-dipalmitoyl-sn-glycero-3-phosphatidylcholine (DPPC) and 1,2-dipalmitoyl-sn-glycero-3-phospho-rac-glycerol (DPPG) is studied by surface pressure (π)−area (A) isotherms and compressibility modulus (C s −1 )−surface pressure (π) isotherms. The location and distribution of ketoprofen molecules in a lipid monolayer under different surface pressures are explored by surface tension, density profile, radial distribution function (RDF), and the potential of mean force (PMF) simulated by molecular dynamics (MD) simulation. The introduction of ketoprofen molecules affects the properties of DPPC/DPPG monolayers and the location and distribution of ketoprofen molecules in monolayers with various surface pressures. The existence of ketoprofen molecules hinders the formation of liquid-condensed (LC) films and decreases the compressibility of DPPC/DPPG monolayers. The location and distribution of ketoprofen molecules in the lipid monolayer are affected by cation−π interaction between the choline group of lipids and the benzene ring of ketoprofen, the steric hindrance of the lipid head groups, and the hydrophobicity of ketoprofen molecule itself, comprehensively. The contact state of lipid head group with water is determined by surface pressure, which affects the interaction between drug molecules and lipids and further dominates the location and distribution of ketoprofen in the lipid monolayer. This work confirms that ketoprofen molecules can affect the property and the inner structure of DPPC/DPPG monolayers during breathing. Furthermore, the results obtained using a mixed monolayer containing two major pulmonary surfactants DPPC/DPPG and ketoprofen molecules will be helpful for the in-depth understanding of the mechanism of inhaled administration therapy.

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Endoscopic evaluation of the effect of ketoprofen, ibuprofen and aspirin on the gastroduodenal mucosa

Cited by 15 publications

References 9 publications

Endoscopic and histopathological evaluation of acute gastric injury in high-dose acetaminophen and nonsteroidal anti-inflammatory drug ingestion with suicidal intent

Endoscopic and histopathological evaluation of acute gastric injury in high-dose acetaminophen and nonsteroidal anti-inflammatory drug ingestion with suicidal intent

Ibuprofen: pharmacology, efficacy and safety

Investigation of Drug for Pulmonary Administration–Model Pulmonary Surfactant Monolayer Interactions Using Langmuir–Blodgett Monolayer and Molecular Dynamics Simulation: A Case Study of Ketoprofen

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