Endoscopic duodenitis, gastric metaplasia and <i>Helicobacter pylori</i>

Urakami, Y; Sendo, Toshiaki

doi:10.1046/j.1440-1746.2001.02482.x

Cited by 14 publications

(14 citation statements)

References 12 publications

(17 reference statements)

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“…However, few studies had focused on the association between the appearance of duodenitis and H. pylori infection. It has been reported that no significant difference exists in the severity of endoscopic duodenitis between H. pylori-positive and -negative patients, and successful eradication of H. pylori did not lead to any change in endoscopic appearance (9). In agreement with this finding, we found that neither the eradication of H. pylori nor the acid suppression treatment could change the appearance of endoscopic nodular duodenitis in a significant manner.…”

Section: Discussionsupporting

confidence: 88%

“…It has been reported that neither the prevalence nor the extent of GM was affected by H. pylori status (5,6,9,22). In contrast, some studies found such a relationship between the extent of GM in the duodenum and the amount of H. pylori in the gastric antrum or in the duodenal bulb (3,4,13,17).…”

Section: Discussionmentioning

confidence: 99%

“…Theoretically, regression of GM may be induced by eradication of H. pylori or acid-suppression therapy. However, published results are conflicting and few studies have focused on the relationship between H. pylori infection and GM in the pathogenesis of duodenitis (4)(5)(6)(7)(8)(9)(10)(11).…”

Section: Introductionmentioning

confidence: 99%

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Duodenal gastric metaplasia and Helicobacter pylori infection in patients with diffuse nodular duodenitis

Chen

et al. 2007

Braz J Med Biol Res

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Whether the regression of gastric metaplasia in the duodenum can be achieved after eradication of Helicobacter pylori is not clear. The aim of the present study was to investigate the relationship between H. pylori infection and gastric metaplasia in patients with endoscopic diffuse nodular duodenitis. Eighty-six patients with endoscopically confirmed nodular duodenitis and 40 control patients with normal duodenal appearance were investigated. The H. pylori-positive patients with duodenitis received anti-H. pylori triple therapy (20 mg omeprazole plus 250 mg clarithromycin and 400 mg metronidazole, all twice daily) for one week. A control endoscopy was performed 6 months after H. pylori treatment. The H. pylori-negative patients with duodenitis received 20 mg omeprazole once daily for 6 months and a control endoscopy was performed 2 weeks after treatment. The prevalence of H. pylori infection was 58.1%, and the prevalence of gastric metaplasia was 57.0%. Seventy-six patients underwent endoscopy again. No influence on the endoscopic appearance of nodular duodenitis was found after eradication of H. pylori or acid suppression therapy. However, gastric metaplasia significantly decreased and complete regression was achieved in 15/28 patients (53.6%) 6 months after eradication of H. pylori, accompanied by significant improvement of other histological alterations. Only mild chronic inflammation, but not gastric metaplasia, was found in the control group, none with H. pylori infection in the duodenal bulb. Therefore, H. pylori infection is related to the extent of gastric metaplasia in the duodenum, but not to the presence of diffuse nodular duodenitis.

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Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 99%

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Duodenal gastric metaplasia and Helicobacter pylori infection in patients with diffuse nodular duodenitis

Chen

et al. 2007

Braz J Med Biol Res

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“…35 Because of the improvement of gastric acid secretion after H. pylori eradication in Japanese H. pylori-positive subjects, the occurrence of erosive duodenitis and refl ux esophagitis 36 after eradication would not be surprising. Although several reports indicate that duodenitis does not deteriorate after H. pylori eradication, 37,38 in the Success-NSAID group of our study, one patient developed erosive duodenitis and two developed refl ux esophagitis without any associated GI symptoms, indicating that a long-term follow-up study may also will be needed.…”

Section: Discussionmentioning

confidence: 54%

Nonsteroidal anti-inflammatory drug use does not affect short-term endoscopic and histologic outcomes after Helicobacter pylori eradication in patients with rheumatoid arthritis

et al. 2007

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We evaluated the effects of the use of nonsteroidal anti-inflammatory drugs (NSAIDs) on endoscopic and histological findings in patients with rheumatoid arthritis (RA) before and after the eradication of Helicobacter pylori infection. Helicobacter pylori (H. pylori) eradication using lansoprazole 30 mg, amoxicillin 750 mg, and clarithromycin 200 mg twice daily for 1 week was conducted in 44 patients (mean age: 56.5 years) with RA. Using the updated Sydney system, endoscopic and histological findings of the greater curvature of the antrum, the greater curvature of the upper corpus, and the lesser curvature of the lower corpus were compared before and after eradication, for a mean follow-up period of 3.5 months. Overall, H. pylori eradication was successful in 32 patients (72.7%). Of these 32 patients, 23 were NSAID users. In the successful eradication group, (1) there was no significant change on endoscopic findings, including gastric erythema and erosion in all three regions irrespective of NSAIDs use; (2) of 17 active ulcers before eradication in NSAIDs users, all healed except for one duodenal ulcer that persisted, where one patient newly developed a gastric ulcer, one developed erosive duodenitis, and two developed reflux esophagitis, all in NSAID users; (3) neutrophil infiltration and chronic inflammation were significantly improved in all three regions after H. pylori eradication irrespective of use of NSAIDs, while atrophic change and intestinal metaplasia did not change. In the eradication failure group; (1) there was no significant change on endoscopic and histological findings in the three regions; (2) two of three ulcers present before eradication on NSAID users persisted even after eradication, and no new cases of gastric ulcer or erosive duodenitis occurred. In conclusion, over a mean follow-up period of 3.5 months, use of NSAIDs in Japanese patients with RA did not impair the healing process of gastric and duodenal ulcers nor did it affect the endoscopic and histological improvements associated with H. pylori eradication.

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“…However, to the best of our knowledge, there is no study that evaluates the microscopic histopathological characteristics of the duodenum and its relationship to H. pylori infection and symptoms of patients with functional dyspepsia and almost all of the previous studies concentrated on gross histopathological changes in duodenal tissue [18][19][20][21][22][23]. Therefore, we decided to evaluate the relationship between microscopic duodenal tissue changes and H. pylori infection with symptoms of patients with functional dyspepsia to clarify the role of microscopic duodenitis in these patients.…”

Section: Introductionmentioning

confidence: 99%

Impact of Helicobacter pylori Infection and Microscopic Duodenal Histopathological Changes on Clinical Symptoms of Patients with Functional Dyspepsia

et al. 2011

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Endoscopic duodenitis, gastric metaplasia and Helicobacter pylori

Abstract: The complete type of gastric metaplasia occurred frequently without H. pylori infection, whereas the incomplete type was frequently associated with H. pylori infection.

Cited by 14 publications

References 12 publications

Duodenal gastric metaplasia and Helicobacter pylori infection in patients with diffuse nodular duodenitis

Duodenal gastric metaplasia and Helicobacter pylori infection in patients with diffuse nodular duodenitis

Nonsteroidal anti-inflammatory drug use does not affect short-term endoscopic and histologic outcomes after Helicobacter pylori eradication in patients with rheumatoid arthritis

Impact of Helicobacter pylori Infection and Microscopic Duodenal Histopathological Changes on Clinical Symptoms of Patients with Functional Dyspepsia

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