Endoscopic detection and resection of dysplasia in inflammatory bowel disease-techniques with videos

Khalid, Sameen; Abbass, Aamer; Khetpal, Neelam; Shen, Bo; Navaneethan, Udayakumar

doi:10.1007/s00384-019-03269-3

Cited by 9 publications

(11 citation statements)

References 65 publications

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“…Identifying neoplastic lesions using an ordinary endoscope is often difficult; therefore, most endoscopists previously performed blind biopsies. Recently, however, chromoendoscopy, a targeted biopsy under magnifying colonoscopy, has come into use for a more efficient detection of neoplastic lesions [5][6][7][8][9][10]. Due to advances in surveillance colonoscopy techniques and the development of high-definition endoscopes, most UC-associated neoplasias (UCANs) that were previously difficult to identify have become endoscopically detectable, and the frequency of well-circumscribed UCANs has increased [6,11,12].…”

Section: Introductionmentioning

confidence: 99%

“…However, proctocolectomy can sometimes lead to postoperative adverse events and may decrease the patient's quality of life. In contrast, management of endoscopically visible dysplastic lesions is best determined by its endoscopic resectability, if the lesion is well-circumscribed and can be removed safely and completely; recent reports recommend endoscopic resection [9][10][11][12]15].…”

Section: Introductionmentioning

confidence: 99%

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Long-Term Outcomes after Endoscopic Submucosal Dissection for Ulcerative Colitis-Associated Dysplasia

et al. 2019

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Introduction: The Surveillance for Colorectal Endoscopic Neoplasia Detection and Management in Inflammatory Bowel Disease Patients: International Consensus Recommendations guidelines recommend surveillance colonoscopy instead of colectomy after the complete removal of “endoscopically resectable” dysplastic lesions in ulcerative colitis (UC). There are no studies on long-term outcomes of endoscopic submucosal dissection (ESD) for UC-associated neoplasia (UCAN). We aimed to evaluate the clinical outcomes of ESD for UC-associated dysplasia (UCAD) during long-term follow-up. Methods: We retrospectively enrolled 17 consecutive UC patients with 22 UCADs, who underwent initial ESD or total proctocolectomy at the Hiroshima University Hospital. The clinicopathological features of the patients and neoplasias and clinical outcomes of ESD were evaluated and compared with those of total proctocolectomy. Results: UCAD in the ESD and total proctocolectomy groups was mostly noted on the left side of the colon, and most lesions were superficial macroscopic lesions. In the ESD group, en bloc resection and histological complete resection rates were 83 and 67%, respectively. One patient died of malignant melanoma; however, none of the patients died of UC-associated carcinoma in both groups. Metachronous neoplasias developed in 5 of the 7 patients in the ESD group. Among the 5 patients with metachronous UCAN, 4 finally underwent total proctocolectomy and 1 underwent additional ESD. Conclusions: ESD for UCAD is a useful method for total excisional biopsy. UC patients with UCAD resected by ESD have a high risk of developing metachronous UCAN during the follow-up period.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Long-Term Outcomes after Endoscopic Submucosal Dissection for Ulcerative Colitis-Associated Dysplasia

et al. 2019

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“…Aunque se pueden lograr tasas de resección completa cuando se realiza REM en fragmentos, hasta en un 10 a un 25% de los casos puede haber recurrencia local a largo plazo. Cabe destacar que las lesiones París 0-IIa o 0-IIa+Is tienen bajo riesgo de invasión, aquellas 0-IIa+c, 0-IIc o 0-Is+c tienen mayor riesgo de invasión submucosa 95 .…”

Section: El Manejo Endoscópico De La Displasia En Enfermedad Inflamatoria Intestinal Debe Ser Realizado Por Un Experto En Técnicas De Resunclassified

Guía de endoscopia en enfermedad inflamatoria intestinal

Cerna-Cardona¹,

Peláez-Luna²,

Casillas-Guzmán³

et al. 2022

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“…They can be broadly classified into visible dysplasia where dysplasia is identified on targeted biopsies from lesions visualized during colonoscopies and invisible dysplasia where dysplasia is identified on random or non-targeted biopsies of colonic mucosa in the absence of a visible lesion. 9,24 Visible dysplasia is of two types, Polypoid where the lesion protrudes from the mucosa into the lumen of the colon or rectum by ≥2.5 mm and non-polypoid, where the lesion is with a protrusion less than 2.5 mm or no protrusion above the mucosa. 9,24 Polypoid is further classified into pedunculated where the lesion is attached to the mucosa by a stalk and sessile where the lesion is not attached by a stalk and the entire base of the lesion is contiguous with the mucosa.…”

Section: Endoscopic Classification Of Dysplasiamentioning

confidence: 99%

“…2 The risk of colorectal cancer is 2-6 times higher in patients with IBD as compared to the general population. 6,7,9,10 The risk of development of CRC in patients with IBD increases with time to 1% at 10 years, 3% at 20 years and 7% at 30 years. 11 In the Asia-Pacific region, the prevalence of CRC due to IBD is 0.3% to 1.8%.…”

Section: Introductionmentioning

confidence: 99%

Types of colorectal cancer and dysplasia associated with inflammatory bowel disease

Almottowa

Alkhars

Hassan

et al. 2022

Int J Community Med Public Health

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Ulcerative colitis (UC) and Crohn’s disease (CD) are two major inflammatory disorders of the intestinal wall collectively known as inflammatory bowel disease (IBD). Colorectal carcinoma (CRC) is the most significant and grave consequence of IBD and is preceded by dysplasia in majority of the cases. In this review we aim to discuss the various types of dysplasia found in patients with CRC due to IBD. A thorough literature search was conducted in online databases such as PubMed, Google Scholar, from which all studies published in the last ten years were included in this review. The major development in diagnostic procedures and visualization modalities have aided our understanding of dysplasia, which is now known to be the strongest predictor and marker for CRC development. However, the unpredictable behavior and progression of dysplasia still warrants vigilant surveillance. Dysplasia has been classified on histological characteristics using grades of dysplasia from ‘negative for dysplasia’ to ‘high grade dysplasia’. On visibility via an endoscope from ‘visible dysplasia’ to ‘invisible dysplasia’ and macroscopic features of ‘conventional dysplasia’ and ‘non-conventional dysplasia’. No single classification can be utilized to define the stage of dysplasia and more importantly predict its progression and outcome of CRC. Using evidence-based medicine an integrated classification expanding on a management algorithm must be formulated by a panel of experts to steer management of the disease. A multidisciplinary, tailored approach with a strong emphasis on regular and timely surveillance to ensure early detection of CRC can enhance quality of life and patient outcomes.

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Endoscopic detection and resection of dysplasia in inflammatory bowel disease-techniques with videos

Cited by 9 publications

References 65 publications

Long-Term Outcomes after Endoscopic Submucosal Dissection for Ulcerative Colitis-Associated Dysplasia

Long-Term Outcomes after Endoscopic Submucosal Dissection for Ulcerative Colitis-Associated Dysplasia

Guía de endoscopia en enfermedad inflamatoria intestinal

Types of colorectal cancer and dysplasia associated with inflammatory bowel disease

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