Endoscopic approaches to pituitary lesions: Difficulties and challenges

Santos, Gonzalo de los; Fragola, Claudio; Castillo, Raúl; Rodriguez, V. M.; D’oleo, Claudio; Reyes, Pablo

doi:10.1016/j.otoeng.2013.08.011

Cited by 2 publications

(7 citation statements)

References 41 publications

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“…A number of studies have investigated the variations in tumor type and size among the examined groups, particularly between early and late groups. Notably, findings from studies such as [ 7 , 16 , 17 , 22 , 23 , 26 , 38 ] indicated that no statistical differences were observed between these groups. The characteristics of the included studies [ 7 , 11 – 43 ] are summarized in Table 1 .…”

Section: Resultsmentioning

confidence: 99%

“…The EETA-LC was evaluated based on a diverse set of variables. The most frequently analyzed variables were postoperative cerebrospinal fluid (CSF) leak in 28 articles (82%) [ 7 , 12 , 13 , 15 – 17 , 19 – 23 , 25 , 27 – 29 , 31 – 43 ], gross total resection (GTR) in 21 articles (62%) [ 7 , 13 , 14 , 16 , 19 , 21 , 22 , 26 – 34 , 36 – 40 ], post operative diabetes insipidus (DI) in 15 articles (44%) [ 12 , 13 , 16 , 17 , 19 , 21 , 22 , 29 – 32 , 34 , 36 , 37 , 41 ], operative time (OT) in 12 articles (35%) [ 7 , 13 , 14 , 16 , 17 , 22 , 29 , 32 , 34 – 36 , 38 ] and visual improvement in 12 articles (35%) [ 13 , 14 , 16 , 21 , 22 , 28 , 31 , 32 , 34 , 36 , 37 , 41 ]. (Fig.…”

Section: Resultsmentioning

confidence: 99%

“…In all the studies included, improvements were observed between early and late-experience stages [ 7 , 11 – 43 ]. Among the evaluated variables, the following improvements were noted: the endocrinological cure rate (EC) showed improvement in all 7 articles out of 7 evaluated [ 13 , 16 , 18 , 21 , 24 , 30 , 33 ], operative time (OT) improved in 11 out of 12 articles (91%) [ 13 , 14 , 16 , 17 , 22 , 29 , 32 , 34 – 36 , 38 ], postoperative cerebrospinal fluid leak (CSF) improved in 23 out of 28 articles (82%) [ 12 , 15 , 17 , 19 , 20 , 22 , 23 , 25 , 27 – 29 , 31 – 35 , 37 – 43 ], visual improvement was observed in 9 out of 12 articles (75%) [ 13 , 14 , 16 , 22 , 28 , 31 , 34 , 37 , 41 ], gross total resection (GTR) improved in 14 out of 21 articles (67%) [ 7 , 13 , 14 , 19 , 21 , 22 , 26 – 30 , 38 – 40 ], hospital length of stay (LOS) decreased in five out of 10 studies (50%) [ 11 , 12 , 16 , 17 , 22 ], and postoperative diabetes insipidus (DI) decreased in 7 out of 15 articles (47%) [ 3 , 14 , 16 , 17 , ...…”

Section: Resultsmentioning

confidence: 99%

“…Moreover, 12 articles (35%) reported both significant and non-significant improvements in outcomes [ 7 , 13 , 14 , 16 , 17 , 21 , 22 , 31 , 32 , 34 , 38 , 41 ]. In 10 studies (29%), solely a trend of improvement was observed [ 11 , 15 , 19 , 20 , 23 , 26 , 27 , 29 , 30 , 40 ], while 8 articles (23%) reported solely significant improvements [ 18 , 24 , 25 , 35 – 37 , 42 , 43 ]. However, in four studies, despite observing a tendency towards better outcomes, no statistical disparities were identified among all assessed variables [ 12 , 28 , 33 , 39 ].…”

Section: Resultsmentioning

confidence: 99%

“…In our review, we reached a similar conclusion. We observed that a substantial portion of articles (68%) utilized group-based learning curve analysis [ 7 , 11 – 13 , 16 , 17 , 19 , 21 – 23 , 26 – 28 , 30 – 34 , 36 – 38 , 42 , 43 ]. Additionally, we similarly noted that papers frequently lacked explanations for the selection of cut points, raising concerns about potential bias resulting from data-dependent splitting.…”

Section: Discussionmentioning

confidence: 99%

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The learning curve in endoscopic transsphenoidal skull-base surgery: a systematic review

Alomari,

Alsarraj,

Alqarni

2024

BMC Surg

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Background The endoscopic endonasal transsphenoidal approach (EETA) has revolutionized skull-base surgery; however, it is associated with a steep learning curve (LC), necessitating additional attention from surgeons to ensure patient safety and surgical efficacy. The current literature is constrained by the small sample sizes of studies and their observational nature. This systematic review aims to evaluate the literature and identify strengths and weaknesses related to the assessment of EETA-LC. Methods A systematic review was conducted following the PRISMA guidelines. PubMed and Google Scholar were searched for clinical studies on EETA-LC using detailed search strategies, including pertinent keywords and Medical Subject Headings. The selection criteria included studies comparing the outcomes of skull-base surgeries involving pure EETA in the early and late stages of surgeons’ experience, studies that assessed the learning curve of at least one surgical parameter, and articles published in English. Results The systematic review identified 34 studies encompassing 5,648 patients published between 2002 and 2022, focusing on the EETA learning curve. Most studies were retrospective cohort designs (88%). Various patient assortment methods were noted, including group-based and case-based analyses. Statistical analyses included descriptive and comparative methods, along with regression analyses and curve modeling techniques. Pituitary adenoma (PA) being the most studied pathology (82%). Among the evaluated variables, improvements in outcomes across variables like EC, OT, postoperative CSF leak, and GTR. Overcoming the initial EETA learning curve was associated with sustained outcome improvements, with a median estimated case requirement of 32, ranging from 9 to 120 cases. These findings underscore the complexity of EETA-LC assessment and the importance of sustained outcome improvement as a marker of proficiency. Conclusions The review highlights the complexity of assessing the learning curve in EETA and underscores the need for standardized reporting and prospective studies to enhance the reliability of findings and guide clinical practice effectively.

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