Gastropleural and gastropericardial fistulas are
abnormal communications between the stomach and the
pleural cavity or pericardium. They are rare and lifethreatening
complications, which require prompt surgical
intervention. We report the case of a gastro-pleuro-pericardial
fistula that developed in a patient treated with
radiotherapy and then Sunitinib (Sutent), a novel tyrosine-
kinase inhibitor, for lung metastases from renal cell
carcinoma. To our knowledge, this is the first case of a
gastro-pleuro-pericardial fistula developing as a consequence
of combined radiation and chemotherapy