Endoscopic and Histologic Findings in the Upper Gastrointestinal Tract of Children with Coeliac Disease

Oderda, Giuseppina; Forni, Marco; Morra, Isabella; Tavassoli, K; Pellegrino, Paolo; Ansaldi, N

doi:10.1097/00005176-199302000-00013

Cited by 37 publications

(33 citation statements)

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“…3 Differences in non-specific findings for CD (e.g. chronic duodenitis, chronic antral gastritis or increased antral intra-epithelial lymphocytes) 5,6 was not statistically significant. Erythematous distal esophageal mucosa on EGD and histopathology suggestive of reflux esophagitis (i.e.…”

Section: Resultsmentioning

confidence: 94%

Features of children with positive celiac serology and type 1 diabetes mellitus

Tanpowpong

Broder‐Fingert

Katz

et al. 2015

Pediatrics International

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Prior studies have reported disparate clinical presentations between children with celiac disease and type 1 diabetes mellitus and those with celiac disease alone. Studies focusing on differences in endoscopic and histopathological findings, however, are limited. We reviewed children aged 2-18 years, presenting for an initial evaluation between January 2000 and December 2010. Data on medical history, serologic markers, upper endoscopy, and histopathology were collected. Only the children with positive celiac serology who had upper endoscopy performed within 3 months of the initial visit were included. We identified 294 children who fulfilled the criteria, 21 of whom had diagnosed type 1 diabetes mellitus. Diabetic children were more likely to have absence of gastrointestinal symptoms. Erythematous duodenal and esophageal mucosa on endoscopy, and histopathology suggestive of reflux esophagitis were more common in the diabetes group. Diabetic children with positive celiac serology had different histopathological features as compared with their non-diabetic counterparts.

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Section: Resultsmentioning

confidence: 94%

Features of children with positive celiac serology and type 1 diabetes mellitus

Tanpowpong

Broder‐Fingert

Katz

et al. 2015

Pediatrics International

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“…This does not allow us to specify the evolution of the metaplasia after gluten withdrawal, especially in the light of the results obtained by Oderda et al (25), who observed a lower prevalence of SIM in the esophagus of coeliac children who followed a gluten-free diet. It is possible that this lesion could evolve differently in adult celiac patients with chronic esophageal reflux.…”

Section: Discussionmentioning

confidence: 89%

Celiac Disease and Intestinal Metaplasia of the Esophagus (Barrett?s Esophagus)

et al. 2005

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Previous studies on celiac patients demonstrated that exposure to gliadin alters the motility of the upper gastrointestinal tract, leading to increased acid reflux. No literature is available regarding the possible presence of specialized intestinal metaplasia of the esophagus as a consequence of chronic reflux in adult celiac patients. Our purpose was to evaluate endoscopically and histologically the esophagi of a group of untreated celiac patients. We studied 60 celiac patients, 13 men and 47 women (mean age, 40 +/- 14 [SD] years; range, 18-80 years), at their first endoscopy (following a normal diet). The distal esophagus was evaluated and multiple biopsies were taken. Hematoxylin-eosin and alcian blue stainings were performed. A group of nonceliac, age- and sex-matched patients was used as a control. We found intestinal metaplasia in the distal esophagus of 16 of 60 (26.6%) celiacs (mean age, 45 +/- 13 years; range, 27-75 years), in comparison with a control-group prevalence of 10.9% (OR, 3.9; 95% CI, 1.4-11.2%). Among the celiac group with metaplasia, only one patient had reflux-like symptoms. None had esophagitis. In conclusion, we observed an increased prevalence of esophageal metaplasia in patients with celiac disease. This finding could be the result of motor abnormalities leading to chronic acid reflux, combined with a mucosa which is sensitive to gliadin.

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“…Glutensiz diyet tedavisi ile olgulardaki özofajit bulgularının ne oranda düzeldiği hakkında veriler yetersiz olmakla beraber, pediatrik yaş grubundaki çölyak hastalarında glutensiz diyet tedavisi altındayken yapılmış olan bir çalışmada ise özofajit sıklığının kontrol grubundan daha düşük olduğu gösterilmiştir (14). Reflü özofajiti olan çölyak hastalarında glutensiz diyet tedavisi ile belirtilerde gerileme olması, glutenin kas hüc-relerine direkt toksik etkili olduğunu düşündürmüştür (15).…”

Section: Discussionunclassified

Evaluation Of Esophagitis In Children With Celiac Disease

Ünal¹,

Baran²,

Cebe³

et al. 2012

Tepecik Dergisi

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ÖZETAmaç: Çölyak hastalığı tanısı alan olgularda özofajit sıklığı, özofajiti olan ve olmayan hastalarda reflü semptomları ve duodenumdaki histopatolojik değerlendirmedeki ağırlık ile özofajit sıklığı arasındaki ilişki araştırılmıştır. Gereç ve Yöntem:Çölyak hastalarının tanı anındaki bulguları geriye dönük tarandı. Hastalar özofajiti olan ve olmayan çölyak hastaları olarak iki gruba ayrıldı. Hastaların histopatolojik bulguları, reflü semptomları ve demografik özellikleri karşılaştırıldı.Bulgular: Çalışmamızda 71 (53%) çölyaklı hastada özofajit bulgularına rastlandı. Özofajitli çölyak hasta grubunda bulantı, kusma, pirozis gibi reflü semptomları daha sık saptanmıştır (p <0,001). Her iki grupta yaş, cinsiyet, vücut boy ölçümleri arasında anlamlı farklılık saptanmadı. Özofajiti olan çölyaklı hastalar ile özofajiti olmayan hastalar arasında histopatolojik sınıf-lamaya (Marsh sınıflaması) göre anlamlı fark saptanmadı. Özofajitli çölyak hastalarındaki Marsh sınıflamasının ağırlığı ile özofajit gelişimi arasında anlamlı bir ilişki saptanmadı.Sonuç: Çölyaklı 71 olguda (%53) özofajit saptandı, özofajit olan hastalarda reflü semptomları daha belirgindi.Anahtar Sözcükler: Çocuk, Çölyak hastalığı, Özofajit SUMMARY Aim: In current study, we evaluated the prevalence of reflux esophagitis in celiac patients. Dyspeptic symptoms were compared between those with and without esophagitis, and investigated the relationship between histopathological grade in duodenum and frequency of esophagitis.

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Endoscopic and Histologic Findings in the Upper Gastrointestinal Tract of Children with Coeliac Disease

Cited by 37 publications

References 0 publications

Features of children with positive celiac serology and type 1 diabetes mellitus

Features of children with positive celiac serology and type 1 diabetes mellitus

Celiac Disease and Intestinal Metaplasia of the Esophagus (Barrett?s Esophagus)

Evaluation Of Esophagitis In Children With Celiac Disease

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