Endoscopic and clinicopathologic characteristics of early gastric cancer with high microsatellite instability

Jahng, Jun Seop; Youn, Young Hoon; Kim, Kwang Hyun; Yu, Jung-Hwan; Lee, Yong Chan; Hyung, Woo Jin; Noh, Sung Hoon; Kim, Hyunki; Kim, Hogeun; Park, Hyojin; Lee, Sang In

doi:10.3748/wjg.v18.i27.3571

Cited by 9 publications

(13 citation statements)

References 23 publications

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“…Finally, a study investigating clinicopathological and molecular features between MLH1 methylation‐positive and ‐negative MSI gastric cancers was not included. Forty‐eight studies published between 1994 and 2016, with a study interval ranging from 1980 and 2013, were included in the review ( Table S2 , supporting information). The total number of patients included was 18 612, ranging from 24 to 2959 per study.…”

Section: Resultsmentioning

confidence: 99%

“…Five of 48 studies (637 patients, 3·4 per cent) were multicentre studies from the USA, Canada, Germany, Korea, Poland, Russia, Ukraine, Vietnam, the UK, South Africa, Chile, Colombia and Japan. The other 43 studies were performed in single centres in Eastern populations (15 529 patients, 83·4 per cent) from Japan, China, Korea and Taiwan, or in Western populations (2446 patients, 13·1 per cent) from Italy, Poland, Slovenia, the UK, Portugal, Brazil and Germany.…”

Section: Resultsmentioning

confidence: 99%

“…Overall, 33 studies used MSI PCR testing alone, five employed immunohistochemistry testing, and ten used both MSI PCR and immunohistochemistry testing to determine MSI status. The overall proportion of patients with MSI was 9·2 per cent (1718 of 18 612), ranging from 5·6 per cent to 33·3 per cent.…”

Section: Resultsmentioning

confidence: 99%

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Meta-analysis of microsatellite instability in relation to clinicopathological characteristics and overall survival in gastric cancer

Połom

Marano

Marrelli

et al. 2017

British Journal of Surgery

213

172

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Meta-analysis of microsatellite instability in relation to clinicopathological characteristics and overall survival in gastric cancer

Połom

Marano

Marrelli

et al. 2017

British Journal of Surgery

213

172

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show abstract

“…Moreover, patients with negative PTEN expression had worse median overall survival than patients with positive PTEN expression ( Figure 3B, p < 0.001). To further find out the risk factor affecting the survival rate of patients, patients were divided into four groups as four different [17]. Moreover, Arai et al showed that much higher amount of cases with MSI were observed with poorly differentiated gastric adenocarcinoma than other subtypes [18].…”

Section: Methodsmentioning

confidence: 99%

The loss of PTEN expression and microsatellite stability (MSS) were predictors of unfavorable prognosis in gastric cancer (GC)

Fan¹,

Qian²,

Zhao³

2021

neo

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The predictors for the prognosis of gastric cancer (GC) are not clear. We intended to explore the role of PTEN and microsatellite (MS) in GC, showing their potential as prognostic markers. Primary gastric cancer tissues, adjacent normal tissues, and clinicopathological parameters of 187 patients were collected. The expression level of PTEN and MS status were classified by immunohistochemistry (IHC). The relationship among indicators was compared by the chi-square test. The survival curves were delineated by Kaplan-Meier and tested by Log-rank methods. The impact of multiple factors on prognosis was determined by COX proportional hazards model. Significantly, PTEN expression was associated with lymphatic invasion (p = 0.011) and Lauren grade (p = 0.015). MS status was associated with differentiation (p = 0.006) and Lauren grades (p = 0.035). TNM stage was associated with MS status under positive PTEN expression (p = 0.014). Patients with microsatellite stability (MSS) had worse median overall surviva l (OS) than that with microsatellite instability (MSI) (p = 0.013). Patients with negative PTEN expression had a worse median OS than that with positive PTEN expression (p < 0.001). The tumor subtype of PTEN negative-MSS (p < 0.001) and PTEN negative-MSI (p = 0.042) were strong predictors of poor survival. Negative PTEN expression and MSS might lead to unfavorable prognosis due to their association with clinicopathological parameters of GC. PTEN expression and MS status could be predictors for the prognosis of GC.

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“…The mechanism of inactivating mutations and deletions of both alleles of a tumor suppressor gene was involved in the process of carcinogenesis. Loss of heterozygosity (LOH) may increase cancer susceptibility, particularly following exposure to environmental carcinogens (9).…”

Section: Introductionmentioning

confidence: 99%

Correlation between gastric carcinoma and ZAC gene-associated microsatellite instability and loss of heterozygosity

Zhu

Yang

et al. 2017

Oncology Letters

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Abstract. The present study explored the association between loss of heterozygosity (LOH) or microsatellite instability (MSI) of the zinc finger regulator of apoptosis and cell-cycle arrest (ZAC) gene and the clinicopathological factors of gastric cancer. Samples of cancer and cancer-adjacent normal tissue from 30 patients with gastric cancer were collected. The genomic DNA was extracted from each and amplified with primers specific to ZAC microsatellite mutations, then run on a polyacrylamide gel for analysis. The CA197 microsatellite locus exhibited LOH in cancer sample 4. There was LOH in the 15AAAG locus in cancer sample 27 and cancer-adjacent tissue 23, and MSI at 15AAAG in cancer-adjacent tissue 27. There was MSI at the D6S1703 microsatellite locus in cancer-adjacent tissue 28. There was no LOH or MSI in the CA340 microsatellite locus in the gastric cancer or adjacent tissues analyzed. Thus, the frequency of LOH or MSI at ZAC gene-associated microsatellite loci for all patients was 13.3% (4/30). The present study has demonstrated that LOH and MSI events may contribute to the downregulation of ZAC; however, it is unlikely to be the primary cause, as it was only identified in 13.3% of cases.

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Endoscopic and clinicopathologic characteristics of early gastric cancer with high microsatellite instability

Abstract: MSI-H EGC is associated with unique endoscopic and clinicopathologic characteristics including frequent presentation in protruded type, co-existing underlying adenoma, and synchronous lesions.

Cited by 9 publications

References 23 publications

Meta-analysis of microsatellite instability in relation to clinicopathological characteristics and overall survival in gastric cancer

Meta-analysis of microsatellite instability in relation to clinicopathological characteristics and overall survival in gastric cancer

The loss of PTEN expression and microsatellite stability (MSS) were predictors of unfavorable prognosis in gastric cancer (GC)

Correlation between gastric carcinoma and ZAC gene-associated microsatellite instability and loss of heterozygosity

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