Endoscope-induced colitis: Description, probable cause by glutaraldehyde, and prevention

Rozen, Paul; Sömjen, Giora J.; Baratz, M; Kimel, R.; Arber, Nadir; Gilat, Tuvia

doi:10.1016/s0016-5107(94)70250-0

Cited by 55 publications

(25 citation statements)

References 16 publications

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“…For these reasons, the use of this high-level disinfectant should be done with containment to minimize aerosolization of glutaraldehyde. Acute colitis occurring after lower GI endoscopy was probably caused by glutaraldehyde residues in the endoscope after disinfection (37). Other disadvantages of glutaraldehyde are coagulation and fixation of proteins and failure to eliminate atypical mycobacteria within standard contact times (5,35,38).…”

Section: Relevance Of Cleaning and Disinfectionmentioning

confidence: 99%

Transmission of Infection by Flexible Gastrointestinal Endoscopy and Bronchoscopy

et al. 2013

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SUMMARY Flexible endoscopy is a widely used diagnostic and therapeutic procedure. Contaminated endoscopes are the medical devices frequently associated with outbreaks of health care-associated infections. Accurate reprocessing of flexible endoscopes involves cleaning and high-level disinfection followed by rinsing and drying before storage. Most contemporary flexible endoscopes cannot be heat sterilized and are designed with multiple channels, which are difficult to clean and disinfect. The ability of bacteria to form biofilms on the inner channel surfaces can contribute to failure of the decontamination process. Implementation of microbiological surveillance of endoscope reprocessing is appropriate to detect early colonization and biofilm formation in the endoscope and to prevent contamination and infection in patients after endoscopic procedures. This review presents an overview of the infections and cross-contaminations related to flexible gastrointestinal endoscopy and bronchoscopy and illustrates the impact of biofilm on endoscope reprocessing and postendoscopic infection.

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Section: Relevance Of Cleaning and Disinfectionmentioning

confidence: 99%

Transmission of Infection by Flexible Gastrointestinal Endoscopy and Bronchoscopy

et al. 2013

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“…Six cases of acute self-limited colitis reported by Rozen et al [13] were found to be due to glutaraldehyde residues in the endoscopes after disinfection in an automatic disinfecting machine. The concentration of these residues were measured during and after five cycles and also in fluid remaining on the surface of the endoscopes.…”

Section: Discussionmentioning

confidence: 93%

Chemical Colitis Due to Glutaraldehyde: Case Series and Review of the Literature

et al. 2008

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Chemical colitis can occur as a result of accidental contamination of endoscopes or by intentional/accidental administration of enemas containing various chemicals.We present three cases of glutaraldehyde induced colitis and review the cases in the literature. Glutaraldehyde induced colitis presents clinically with severe abdominal pain, bloody and mucoid diarrhea, rectal bleeding, and tenesmus 48-72 h after colonoscopy. Endoscopic findings are nonspecific and mimic ischemic colitis, inflammatory bowel disease, and infectious colitis. The timing of symptoms and the knowledge that glutaraldehyde is a chemical irritant to colonic mucosa is important for the diagnosis. The treatment is mainly supportive but sometimes necessitates mesalamine, prednisolone, or metronidazole and the resolution is rapid. In endoscopy units, strict adherence to published disinfection protocols is very important and the cleaning, rinsing and drying protocols also deserve the same attention.

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“…3 This is prevented by frequently changing the rinse water during equipment cleansing and using forced air to dry the instruments. 4 Hydrogen peroxide, another commonly used disinfectant, is associated with pseudolipomatous changes in the mucosa. 5 Changes induced by surgery and other therapies Diversion colitis Diversion of the fecal stream through an ileostomy or colostomy may result in colitis of the remaining distal colorectum, or "Hartmann pouch".…”

Section: Disinfectant Colitismentioning

confidence: 99%

Histopathology of iatrogenic injury in the colorectum

Lam-Himlin

Arnold

Montgomery

2011

Diagnostic Histopathology

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Endoscope-induced colitis: Description, probable cause by glutaraldehyde, and prevention

Cited by 55 publications

References 16 publications

Transmission of Infection by Flexible Gastrointestinal Endoscopy and Bronchoscopy

Transmission of Infection by Flexible Gastrointestinal Endoscopy and Bronchoscopy

Chemical Colitis Due to Glutaraldehyde: Case Series and Review of the Literature

Histopathology of iatrogenic injury in the colorectum

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