“…It was previously shown that some proteolytic fragments of larger proteins can have angiostatic functions. These include cleavage products of extracellular matrix proteins such as endostatin, a C-terminal fragment of collagen XVIII; tumstatin, a fragment of the noncollagenase 1 (NCI) domain of the a3 chain of type IV collagen; endorepellin, a C-terminal domain of the heparan sulfate proteoglycan perlecan; and angiostatin and K1-5, both fragments of plasminogen (O'Reilly et al, 1994(O'Reilly et al, , 1997Cao et al, 1999;Maeshima et al, 2000;Mongiat et al, 2003). Vasostatin, a fragment derived from calreticullin, and PEX-c, the C-terminal cleavage product of MMP-2, also have antiangiogenic functions (Brooks et al, 1998;Pike et al, 1998).…”