Endoplasmic Reticulum Stress Response

Reis, Pedro A. B.; Soares-Ramos, Juliana R.L.; Fontes, Elizabeth P. B.

doi:10.5772/15616

Cited by 2 publications

(2 citation statements)

References 42 publications

(52 reference statements)

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“…13,14 This pathway integrates the ER-stress and osmotic-stress signals to increase the synergistic expression of N-rich proteins (NRP-A and NRP-B) and an NAC domaincontaining protein, GmNAC6, which are critical mediators of stress-induced cell death in plants. [13][14][15][16] This cell death integrated pathway has emerged as a relevant adaptive response of plant cells to multiple environmental stimuli. 16 The soybean GmERD15 homolog has been described as a new ER stress-and osmotic stress-induced transcription factor that binds to the promoter and induces the expression of the NRP-B gene.…”

Section: A Soybean Erd15 Homolog (Gmerd15) Connectsmentioning

confidence: 99%

“…[13][14][15][16] This cell death integrated pathway has emerged as a relevant adaptive response of plant cells to multiple environmental stimuli. 16 The soybean GmERD15 homolog has been described as a new ER stress-and osmotic stress-induced transcription factor that binds to the promoter and induces the expression of the NRP-B gene. In fact, GmERD15 was isolated by its capacity ©2 0 1 1 L a n d e s B i o s c i e n c e .…”

Section: A Soybean Erd15 Homolog (Gmerd15) Connectsmentioning

confidence: 99%

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EARLY RESPONSIVE to DEHYDRATION 15, a new transcription factor that integrates stress signaling pathways

Alves

Fontes

Fietto

2011

Plant Signaling & Behavior

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Section: A Soybean Erd15 Homolog (Gmerd15) Connectsmentioning

confidence: 99%

Section: A Soybean Erd15 Homolog (Gmerd15) Connectsmentioning

confidence: 99%

EARLY RESPONSIVE to DEHYDRATION 15, a new transcription factor that integrates stress signaling pathways

Alves

Fontes

Fietto

2011

Plant Signaling & Behavior

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The hexokinase “HKDC1” interaction with the mitochondria is essential for hepatocellular carcinoma progression

Khan

Terry

Priyadarshini

et al. 2021

Preprint

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Hepatocellular carcinoma (HCC) is a leading cause of death from cancer malignancies. Recently, hexokinase domain containing 1 (HKDC1), was shown to have significant overexpression in HCC compared to healthy tissue. Using in vitro and in vivo tools, we examined the role of HKDC1 in HCC progression. Importantly, HKDC1 ablation stops HCC progression by promoting metabolic reprogramming by shifting glucose flux away from the TCA cycle. Next, HKDC1 ablation leads to mitochondrial dysfunction resulting in less cellular energy which cannot be compensated by enhanced glucose uptake. And finally, we show that the interaction of HKDC1 with the mitochondria is essential for its role in HCC progression, and without this mitochondrial interaction mitochondrial dysfunction occurs. In sum, HKDC1 is highly expressed in HCC cells compared to normal hepatocytes, therefore targeting HKDC1, specifically its interaction with the mitochondria, reveals a highly selective approach to target cancer cells in HCC.

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Endoplasmic Reticulum Stress Response

Cited by 2 publications

References 42 publications

EARLY RESPONSIVE to DEHYDRATION 15, a new transcription factor that integrates stress signaling pathways

EARLY RESPONSIVE to DEHYDRATION 15, a new transcription factor that integrates stress signaling pathways

The hexokinase “HKDC1” interaction with the mitochondria is essential for hepatocellular carcinoma progression

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