Endoplasmic Reticulum Stress in Osteoarthritis: A Novel Perspective on the Pathogenesis and Treatment

Wen, Zeqin; Sun, Qizhen; Shan, Yunhan; Xie, Wenqing; Ding, Yilan; Wang, Weiyang; Ye, Ruixi; Xiao, Wei; Li, Yusheng

doi:10.14336/ad.2022.0725

Cited by 9 publications

(8 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The fact that endoplasmic reticulum stress is involved in OA pathological changes may explain the expression magnitude in OA with DM (Ref. 56 ).…”

Section: Discussionmentioning

confidence: 99%

Impact of diabetes mellitus on osteoarthritis: a scoping review on biomarkers

Seow,

Mat,

Ahmad Azam

et al. 2024

Expert Rev. Mol. Med.

View full text Add to dashboard Cite

Osteoarthritis (OA) commonly affects the knee and hip joints and accounts for 19.3% of disability-adjusted life years and years lived with disability worldwide (Refs 1, 2). Early management is important in order to avoid disability uphold quality of life (Ref. 3). However, a lack of awareness of subclinical and early symptomatic stages of OA often hampers early management (Ref. 4). Moreover, late diagnosis of OA among those with severe disease, at a stage when OA management becomes more complicated is common (Refs 5, 6, 7, 8). Established risk factors for the development and progression of OA include increasing age, female, history of trauma and obesity (Ref. 9). Recent studies have also drawn a link between OA and metabolic syndrome, which is characterized by insulin resistance, dyslipidaemia and hypertension (Refs 10, 11).

show abstract

“…The fact that endoplasmic reticulum stress is involved in OA pathological changes may explain the expression magnitude in OA with DM (Ref. 56 ).…”

Section: Discussionmentioning

confidence: 99%

Impact of diabetes mellitus on osteoarthritis: a scoping review on biomarkers

Seow,

Mat,

Ahmad Azam

et al. 2024

Expert Rev. Mol. Med.

View full text Add to dashboard Cite

show abstract

“…Last but not least, endoplasmic reticulum (ER) stress may bridge the link between NAFLD and OA. ER stress plays a key role in the pathogenesis and progression of bone and joint diseases, involving ER stress in cartilage degradation, synovitis, meniscal lesions, and subchondral bone remodeling[ 42 ]. Besides, evidence supports the notion that the existence of ER stress can trigger the occurrence and progression of a variety of liver diseases, especially NAFLD[ 43 , 44 ].…”

Section: Discussionmentioning

confidence: 99%

Association of non-alcoholic fatty liver disease with self-reported osteoarthritis among the US adults

Lu,

Zhang,

et al. 2024

Arthritis Res Ther

View full text Add to dashboard Cite

Background The association between non-alcoholic fatty liver disease (NAFLD) and osteoarthritis (OA) has not been well elucidated. The aim of the present study was to investigate the association between NAFLD and OA in the US adults. Methods A cross-sectional study was performed on participants in the 2017–2018 National Health and Nutrition Examination Survey (NHANES) cycle. NAFLD was defined by the vibration-controlled transient elastography. The diagnosis of OA was based on self-reported data. Weighted multiple logistic regression models and stratified analyses were performed to explore the relationship and verify the stability of the conclusions. Sensitivity analysis using multiple imputation for missing data and propensity score matching (PSM) were performed. Results In total, 2622 participants [Male: 1260 (47.8%)] were included in this study with a mean age of 48.1 years old (95% CI, 46.6–49.6 years old), containing 317 (12.8%) OA patients and 1140 NAFLD patients (41.5%). A logistic regression indicated a significant association between NAFLD and OA without adjustment [odds ratio (OR) = 2.05; 95% CI, 1.52–2.78]. The association remained stable after adjustment for covariates (OR = 1.72; 95% CI, 1.26–2.34). Sensitivity analysis of missing data with multiple interpolation and PSM found similar results. A significant and consistent association of NAFLD with OA was still observed in each subgroup stratified by age and metabolic syndrome (MetS). Stratified by sex, obesity, and sensitivity c-reactive protein (hs-CRP) category, a statistically significant association was only shown in females, those without obesity, and those without hyper hs-CRP. The results illustrated that the relationship between NAFLD and OA was stable in all subgroups and had no interaction. Conclusions NAFLD was positively correlated with OA. Given the current pandemic of NAFLD and OA, clinicians should screen for NAFLD in arthritis patients and intervene early.

show abstract

“…Protein mistargeting causes organelle dysfunction and cellular and organismal stress, ATP13A1 has been identified as a quality control factor by removing mislocalised mitochondrial tail-anchored proteins from the endoplasmic reticulum (ER), thus maintaining the homeostasis of ER and mitochondria 61 62. Considering the crucial roles of ER and mitochondria in OA pathogenesis,63 64 ATP13A1 may play a beneficial impact on OA by preserving the healthy status of the two organelles, which merit further investigation.…”

Section: Discussionmentioning

confidence: 99%

Evaluating the causal effect of circulating proteome on the risk of osteoarthritis-related traits

Zhang,

Xie,

Wen

et al. 2023

Ann Rheum Dis

View full text Add to dashboard Cite

ObjectivesThis study aims to identify circulating proteins that are causally associated with osteoarthritis (OA)-related traits through Mendelian randomisation (MR)-based analytical framework.MethodsLarge-scale two-sample MR was employed to estimate the effects of thousands of plasma proteins on 12 OA-related traits. Additional analyses including Bayesian colocalisation, Steiger filtering analysis, assessment of protein-altering variants and mapping expression quantitative trait loci to protein quantitative trait loci were performed to investigate the reliability of the MR findings; protein–protein interaction, pathway enrichment analysis and evaluation of drug targets were conducted to deepen the understanding and identify potential therapeutic targets of OA.ResultsDozens of circulating proteins were identified to have putatively causal effects on OA-related traits, and a majority of these proteins were either drug targets or considered druggable.ConclusionsThrough MR analysis, we have identified numerous plasma proteins associated with OA-related traits, shedding light on protein-mediated mechanisms and offering promising therapeutic targets for OA.

show abstract

Endoplasmic Reticulum Stress in Osteoarthritis: A Novel Perspective on the Pathogenesis and Treatment

Cited by 9 publications

References 18 publications

Impact of diabetes mellitus on osteoarthritis: a scoping review on biomarkers

Impact of diabetes mellitus on osteoarthritis: a scoping review on biomarkers

Association of non-alcoholic fatty liver disease with self-reported osteoarthritis among the US adults

Evaluating the causal effect of circulating proteome on the risk of osteoarthritis-related traits

Contact Info

Product

Resources

About