Endoplasmic reticulum stress activation during total knee arthroplasty

Hocker, Austin D.; Boileau, Ryan M.; Lantz, Brick A.; Jewett, Brian A.; Gilbert, Jeffrey S.; Dreyer, Hans C.

doi:10.1002/phy2.52

Cited by 14 publications

(25 citation statements)

References 57 publications

(125 reference statements)

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“…The total tourniquet time was recorded for each subject. All subjects also had three muscle biopsies performed at baseline (prior to tourniquet inflation), during maximal ischemia, and during reperfusion from the vastus lateralis muscle of the operated leg (results not reported here) (56,60,61).…”

Section: Figurementioning

confidence: 99%

Essential amino acid supplementation in patients following total knee arthroplasty

Dreyer¹,

Strycker²,

Senesac³

et al. 2013

J. Clin. Invest.

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Background. By the year 2030, 3.48 million older U.S. adults are projected to undergo total knee arthroplasty (TKA). Following this surgery, considerable muscle atrophy occurs, resulting in decreased strength and impaired functional mobility. Essential amino acids (EAAs) have been shown to attenuate muscle loss during periods of reduced activity and may be beneficial for TKA patients.Methods. We used a double-blind, placebo-controlled, randomized clinical trial with 28 older adults undergoing TKA. Patients were randomized to ingest either 20 g of EAAs (n = 16) or placebo (n = 12) twice daily between meals for 1 week before and 2 weeks after TKA. At baseline, 2 weeks, and 6 weeks after TKA, an MRI was performed to determine mid-thigh muscle and adipose tissue volume. Muscle strength and functional mobility were also measured at these times.Results. TKA patients receiving placebo exhibited greater quadriceps muscle atrophy, with a -14.3 ± 3.6% change from baseline to 2 weeks after surgery compared with -3.4 ± 3.1% for the EAA group (F = 5.16, P = 0.036) and a -18.4 ± 2.3% change from baseline to 6 weeks after surgery for placebo versus -6.2 ± 2.2% for the EAA group (F = 14.14, P = 0.001). EAAs also attenuated atrophy in the nonoperated quadriceps and in the hamstring and adductor muscles of both extremities. The EAA group performed better at 2 and 6 weeks after surgery on functional mobility tests (all P < 0.05). Change in quadriceps muscle atrophy was significantly associated with change in functional mobility (F = 5.78, P = 0.021).Conclusion. EAA treatment attenuated muscle atrophy and accelerated the return of functional mobility in older adults following TKA.Trial registration. Clinicaltrials.gov NCT00760383.

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Section: Figurementioning

confidence: 99%

Essential amino acid supplementation in patients following total knee arthroplasty

Dreyer¹,

Strycker²,

Senesac³

et al. 2013

J. Clin. Invest.

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“…Under anesthetic condition two pneumatic tourniquets were used, one in the right forelimb and the other in the left hindlimb. Capillary irrigation is not present at 230±20 mmHg (Corona & Rathbone, 2014;Hocker et al;Walters et al;Woitaske & McCarter, 1998) so, established pressure of compression was 270 mmHg during one (1) or three (3) hours. After this procedure, postoperative analgesia were provided to all animals.…”

Section: Methodsmentioning

confidence: 99%

“…Ischemia less than six hours occur frequently in two situations, the first, relates to orthopedic surgery, including arthroscopic knee, ankle and wrist, where the interval of time for these procedures is between 15 min to 60 min; the use of a pneumatic tourniquet is necessary in these surgical treatments (Hocker et al, 2013). The other condition occurs in traumatic injuries that occur in remote areas, where access to medical care, could take at least three hours of travel; in these situations a manual tourniquet is useful.…”

Section: Introductionmentioning

confidence: 99%

Image Analysis of Oxidative and Glycolytic Muscle Fibers During Reperfusion Injury by Segmentation Based on Regions

Salazar

2016

Int. J. Morphol.

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ROSERO-SALAZAR, D. H.Image analysis of oxidative and glycolytic muscle fibers during reperfusion injury by segmentation based on regions. Int. J. Morphol., 34(1):127-135, 2016. SUMMARY: Different situations cause ischemia and reperfusion injury, affecting tissues under the level of compression. In this research, abnormal characteristics in distribution of muscle fibers types in soleus and extensor carpi radialis longus, during short periods of ischemia and short and long periods of reperfusion, were determined. Fibers were classified by enzyme histochemistry techniques NADH-TR and myosin-ATPase. Measurements of areas were carried out through semiautomatic image processing by using segmentation based on regions, which evidenced significant changes in distribution during reperfusion followed to one and three hours of ischemia, as well as in comparisons of areas for all periods of reperfusion. This study strengthens the evidence about using practical procedures of image analysis in the diagnosis of tisular abnormalities.

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“…The pressure of ischemia was adjusted at 260 mmHg during one or three hours regarding to each experimental group. This pressure is suitable to perform a complete ischemic condition; due to microcirculatory blood flow is not present at 230 mmHg ± 20 mmHg [1,4,15,21]. Once the time of ischemia finished, both tourniquets were removed.…”

Section: Surgical Proceduresmentioning

confidence: 99%

“…Also, controlling bleeding due to accidents occurring in distant places and treatments for joint diseases or contractures requires a tourniquet. The use of the tourniquet entails reversible injury triggered by ischemic conditions during determined periods of time [1][2][3]. Arthroscopic procedures, for instance, are performed during 15 to 60 minutes, while to transport an injured person from far places to the nearest health institution, can require two to three hours.…”

Section: Introductionmentioning

confidence: 99%

Recovery of Skeletal Striated Muscle Tissue in a Model of Reversible Injury

Otoya¹,

Salazar²

2017

Biol Med

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Reversible injury is a dynamic condition in tissues exposed to multiple harm situations including ischemia and post-ischemic recovery, in which the skeletal striated muscle tissue evidences histopathological characteristics to adapt to damage. During the inflammation and the regeneration phases of healing, the myocytes show morphological changes with an apparently complete recovery at the end of the treatment. Though the satellite cells play a key role in the recovery, not in all cases the regeneration is completely achieved. That is why in this research we measured the histopathological patterns evidenced by enzyme histochemistry and morphometric measurements, during the spontaneous recovery of skeletal muscle fibers underwent to short periods of ischemia of one and three hours and prolonged periods of reperfusion up to 32 days (768 hours). The selected muscles were the extensor carpi radialis longus and the soleus from Wistar rats.There were significant differences in the distribution of type of fibers, shape, size, leukocyte infiltration, necrosis and presence of central nuclei. The soleus muscle adapts better during early reperfusion than extensor carpi radialis longus does. Nevertheless, both muscles evidenced an incomplete recovery at day 32. The extrapolation of these findings suggests the importance of further following up of patients and the improvement of recovery the muscle function after surgery and/or other harm conditions.

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Endoplasmic reticulum stress activation during total knee arthroplasty

Cited by 14 publications

References 57 publications

Essential amino acid supplementation in patients following total knee arthroplasty

Essential amino acid supplementation in patients following total knee arthroplasty

Image Analysis of Oxidative and Glycolytic Muscle Fibers During Reperfusion Injury by Segmentation Based on Regions

Recovery of Skeletal Striated Muscle Tissue in a Model of Reversible Injury

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