Endoplasmic Reticulum Dysfunction: An Emerging Mechanism of Vitiligo Pathogenesis
Yongyi Xie,
Nanhui Wu,
Suwei Tang
et al.
Abstract:The endoplasmic reticulum (ER) is the main site of protein synthesis, transport, and modification. Its abnormal status has now emerged as an established cause of many pathological processes, such as tumors and autoimmune diseases. Recent studies also demonstrated that the defective functions of ER may lead to pigmentary diseases. Vitiligo is a depigmenting ailment skin disorder whose pathogenesis is now found to be associated with ER. However, the detailed mechanism is still unclear. In this review, we try to … Show more
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