Endophytic Microflora of Sri Lankan Plants: An Overview of the Therapeutic and Agricultural Applications of the Secondary Metabolites

Alwis, Y. Vindula; Wethalawe, A. Nethma; Udukala, Dinusha Nishani; Paranagama, P.A.

doi:10.1007/978-981-15-9371-0_8

Cited by 1 publication

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“…The significant role of fungal species in producing antibiotics is elicited after the discovery of Penicillin G in 1928 [ 7 ]. Symbiotic fungal species like endophytic fungi are known to produce a plethora of antimicrobial compounds pertinent in therapeutics and agriculture [ 37 ]. Similar to other symbiotic fungi, ELF produces several secondary metabolites, which protect the lichen from biotic as well as abiotic stress [ 38 ].…”

Section: Antimicrobial Compounds Extracted From Endolichenic Fungimentioning

confidence: 99%

Antimicrobial Compounds Isolated from Endolichenic Fungi: A Review

Wethalawe¹,

Alwis²,

Udukala³

et al. 2021

Molecules

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A lichen is a symbiotic relationship between a fungus and a photosynthetic organism, which is algae or cyanobacteria. Endolichenic fungi are a group of microfungi that resides asymptomatically within the thalli of lichens. Endolichenic fungi can be recognized as luxuriant metabolic artists that produce propitious bioactive secondary metabolites. More than any other time, there is a worldwide search for new antibiotics due to the alarming increase in microbial resistance against the currently available therapeutics. Even though a few antimicrobial compounds have been isolated from endolichenic fungi, most of them have moderate activities, implying the need for further structural optimizations. Recognizing this timely need and the significance of endolichenic fungi as a promising source of antimicrobial compounds, the activity, sources and the structures of 31 antibacterial compounds, 58 antifungal compounds, two antiviral compounds and one antiplasmodial (antimalarial) compound are summarized in this review. In addition, an overview of the common scaffolds and structural features leading to the corresponding antimicrobial properties is provided as an aid for future studies. The current challenges and major drawbacks of research related to endolichenic fungi and the remedies for them have been suggested.

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Section: Antimicrobial Compounds Extracted From Endolichenic Fungimentioning

confidence: 99%