Endophytic actinobacteria of Hymenachne amplexicaulis from the Brazilian Pantanal wetland produce compounds with antibacterial and antitumor activities

Assad, Beatriz Marques; Savi, Daiani Cristina; Biscaia, Stellee Marcela Petris; Mayrhofer, Bárbara F.; Iantas, Jucélia; Mews, Mathias; Oliveira, Juliana Gomes Ramalho de; Trindade, Edvaldo S.; Glienke, Chirlei

doi:10.1016/j.micres.2021.126768

Cited by 14 publications

(9 citation statements)

References 139 publications

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“…Furthermore, Hu et al found that the short-chain fatty acids produced by Firmicutes and Bacteroides in the cow’s gut can prevent lipopolysaccharides produced in the rumen from entering the bloodstream and mammary tissue, thus protecting mammary gland lactation function ( 50 ). Bifidobacterium can improve digestion, enhance blood glucose control, and lower lipid levels through the gut-stomach axis ( 57 , 58 ). Factors secreted by intestinal microbiota, such as GLP-1, ghrelin, and 5-HT, can regulate the metabolic balance of blood glucose in the host by influencing the α/β cell function of the pancreas, supporting the gut-pancreas axis theory ( 78 ).…”

Section: Physiological Functions Of Cow Gastrointestinal Microorganismsmentioning

confidence: 99%

Research progress on the regulation of production traits by gastrointestinal microbiota in dairy cows

Liu,

Wu,

Guo

et al. 2023

Front. Vet. Sci.

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The composition and abundance of microorganisms in the gastrointestinal tract of cows are complex and extensive, and they play a crucial role in regulating nutrient digestion, absorption, maintaining digestive tract stability, and promoting the production and health of the host. The fermentation carried out by these microorganisms in the gastrointestinal tract is fundamental to the health and productivity of cows. Rumen microorganisms produce the majority of enzymes required to break down feed substrates, such as cellulose, protein, lipids, and other plant materials, through fermentation. This process provides energy metabolism substrates that satisfy approximately 70% of the host’s energy requirements for physiological activities. Gut microorganisms primarily decompose cellulose that is difficult to digest in the rumen, thereby providing heat and energy to the hosts. Additionally, they have an impact on host health and productivity through their role in immune function. Understanding the composition and function of the cow gut microbiota can help regulate dairy cattle breeding traits and improve their health status. As a result, it has become a popular research topic in dairy cattle breeding. This article provides a review of the composition, structure, physiological characteristics, and physiological effects of the cow gut microbiota, serving as a theoretical foundation for future studies that aim to utilize the gut microbiota for dairy cattle breeding or improving production traits. It may also serve as a reference for research on gut microbiota of other ruminants.

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Section: Physiological Functions Of Cow Gastrointestinal Microorganismsmentioning

confidence: 99%

Research progress on the regulation of production traits by gastrointestinal microbiota in dairy cows

Liu,

Wu,

Guo

et al. 2023

Front. Vet. Sci.

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“…Crude extracts of isolates of Streptomyces albidoflavus CMRP4852 and Verrucosispora sp. CMR P4860 demonstrated anti-melanoma activities with no effect on normal non-cancerous cells [ 112 ]. Consequently, the natural products synthesized by endophytic bacteria have attracted enormous interest and research on these strains [ 113 ].…”

Section: Production Of Secondary Metabolitesmentioning

confidence: 99%

Secondary Metabolites Produced by Plant Growth-Promoting Bacterial Endophytes

Narayanan

Glick

2022

Microorganisms

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There is an increasing interest in the use of beneficial microorganisms as alternatives to chemically synthesized or plant-derived molecules to produce therapeutic agents. Bacterial endophytes are plant-associated microorganisms that can colonize different parts of living plants without causing any diseases. Diverse endophytic bacteria possess the ability to synthesize a wide range of secondary metabolites with unique chemical structures that have been exploited for their anti-microbial, antiviral, anti-cancer, and anti-inflammatory properties. Additionally, production of these bioactive compounds can also benefit the host plant as they may play a significant role in a plant’s interaction with the environment for adaptation and defense. As a result of their significant impact as curative compounds or as precursors to produce new drugs, the biotechnological possibilities of secondary metabolites derived from endophytic bacteria are immense.

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“…According to the World Health Organization (WHO), with current measures for the treatment of cervical carcinoma, the number of deaths could increase by half in the coming years [ 2 ]. With increasing resistance to the current drugs available against cervical carcinoma, natural products have gained momentum, owing to the rich diversity of secondary metabolites produced by the vast array of flora and fauna, many of which are still unexplored [ 3 , 4 ].…”

Section: Introductionmentioning

confidence: 99%

Inhibition of Autophagy Increases Cell Death in HeLa Cells through Usnic Acid Isolated from Lichens

Kumari

Kamat

Singh

et al. 2023

Plants

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The Western Ghats, India, is a hotspot for lichen diversity. However, the pharmacological importance of lichen-associated metabolites remains untapped. This study aimed to evaluate the cytotoxic potential of lichens of this region. For this, sixteen macrolichens were collected and identified from two locations in the Western Ghats. The acetone extract of Usnea cornuta (UC2A) showed significant cytotoxicity towards multiple human cancer cell lines. Interestingly, co-treatment with chloroquine (CQ), an autophagy inhibitor, increased the cytotoxic potential of the UC2A extract. A gas chromatography mass spectrometry (GCMS) study revealed usnic acid (UA), atraric acid and barbatic acid as the dominant cytotoxic compounds in the UC2A extract. Further, UA was purified and identified from the UC2A extract and evaluated for cytotoxicity in HeLa cells. The monodansyl cadaverine and mitotracker red double staining revealed the autophagy-inducing activities of UA, and the inhibition of autophagy was confirmed via CQ treatment. Autophagy inhibition increased the cytotoxicity of UA by 12–16% in a concentration-dependent manner. It also increased lipid peroxidation, ROS levels and mitochondrial depolarization and decreased glutathione availability. A decrease in zeta potential and a 40% increase in caspase 3/7 activity were also noted after CQ treatment of UA-treated cells. Thus, cytotoxicity of UA can be increased by inhibiting autophagy.

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Endophytic actinobacteria of Hymenachne amplexicaulis from the Brazilian Pantanal wetland produce compounds with antibacterial and antitumor activities

Cited by 14 publications

References 139 publications

Research progress on the regulation of production traits by gastrointestinal microbiota in dairy cows

Research progress on the regulation of production traits by gastrointestinal microbiota in dairy cows

Secondary Metabolites Produced by Plant Growth-Promoting Bacterial Endophytes

Inhibition of Autophagy Increases Cell Death in HeLa Cells through Usnic Acid Isolated from Lichens

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