Endophthalmitisrate mit und ohne topische postoperative Antibiotikagabe nach intravitrealer Avastin-Injektion

Abstract

Although equal treatment guidelines were established, the perioperative hospital admission and postoperative application of topical antibiotic ointment could not reduce the occurrence of mild to severe intraocular endophthalmitis.

Retinal Diseases Associated with Oxidative Stress and the Effects of a Free Radical Scavenger (Edaravone)

“…An intravitreal injection is the most common and widely recommended route of drug administration to treat posterior ocular diseases [ 98 ]. However, this method is highly invasive and is associated with the risk of infection (0.02 to 1.6%) [ 99 – 103 ]. In addition, the anti-VEGF antibody is very expensive, and the financial burden on patients with the wet type of AMD is extremely high.…”

Intracameral bevacizumab for rubeotic glaucoma secondary to retinal vein occlusion

“…Anti-VEGF medications have offered a potential new direction in the management of patients with iris neovascularisation. Intravitreal administrations of such medications are associated with morbidity from endophthalmitis, retinal detachments and suprachoroidal haemorrhages [1,2]. Intracameral administration, however, has not been associated with any morbidity, in a case series of three patients [3].…”

“…Anti-VEGF agents are a novel additional treatment for rubeotic glaucoma by interfering with the angiogenic process. Intravitreal injections of such medications have been used, with some benefit, but with a risk of retinal damage and endophthalmitis [1]. Intracameral injection of anti-VEGF agent may be less invasive than intravitreal delivery, but the efficacy of this route of administration is uncertain.…”

Neue Aspekte in der Therapie der neovaskulären altersabhängigen Makuladegeneration – Aktuelle Stellungnahme der Retinologischen Gesellschaft, der Deutschen Ophthalmologischen Gesellschaft und des Berufsverbands der Augenärzte Deutschlands e. V.

“…B. bei der Katarakt-OP oder der Vitrektomie [44]. Für die von manchen Autoren [45] und in der Fachinformation für Lucentis ® [13] geforderte präoperative Prophylaxe mit topischen Antibiotika gibt es unverändert keine evidenzbasierten Daten [46,47] ▶ Nachweis von 500 intraokularen Eingriffen (keine Lasertherapien) oder 100 intravitrealen Injektionen (alternativ Nachweis der "Fachkunde Ophthalmochirurgie").…”