Endophthalmitis Due to Brevibacterium Casei

Banu, Asima; Sriprakash, K S; M, Vidyadevi; Nagraj, E R

doi:10.21767/amj.2013.1523

Cited by 4 publications

(5 citation statements)

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“…Table 3 represents the centrality measures obtained through network analysis. The measured values of Caspase-6 (CASP6) were degree (10), betweenness (.076296296), closeness (1), radiality (1), eccentricity (1) and stress (28), as well as substantial nodes in the network association, have exposed the threshold value of all measures as well as important nodes in the network association.…”

Section: Molecular Docking Studiesmentioning

confidence: 99%

“…Molecular docking, a method that samples the ensemble of binding modes to forecast optimal pose(s) in which the compound being studied can engage with the receptor at a specific place, known as the active/binding site, to form a stable complex, can be used for virtual screening [26]. The use of molecular docking simulation in structure-based drug design allows for a better understanding of the interactions between the ligand molecule and the target protein [27,28]. Molecular dynamic simulation is helpful in understanding the stability of the GEDT with Caspase-6 protein for a time period of 100 ns [29].…”

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confidence: 99%

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Exploring the co‐activity of FDA approved drug gemcitabine and docetaxel for enhanced anti‐breast cancer activity: DFT, docking, molecular dynamics simulation and pharmacophore studies

Sukumaran,

Zochedh,

Chandran

et al. 2024

Int J of Quantum Chemistry

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Combining FDA‐approved medications may increase biological activity by simultaneously targeting many protein mechanisms while being less toxic. Gemcitabine and docetaxel together might have a synergistic impact that kills cancer cells and makes them more effective against breast cancer. This study used the foundation set B3LYP/6–311 G to optimize the gemcitabine with the docetaxel structure that was created. Theoretical calculations were made for the ultraviolet to visible spectrum were studied in gas and liquid phase. The structural stability and reactivity of the combined structure were studied using the energy gap between HOMO and LUMO, and the computed energy gap (ΔE) was 4.219 eV. The electrostatic potential of complex structure was determined and the Mulliken charge population was evaluated. Through RDG analysis weak interactions of GEDT was evaluated and topology properties were studied through ELF and LOL analysis. Breast cancer target proteins were utilized in the molecular docking studies. The docking scores revealed a greater binding affinity for the complex molecule, confirming a superior combinatorial interaction between gemcitabine and docetaxel. Highest binding ability of the GEDT was against Caspase‐6 and the network analysis of Caspase‐6 was assessed through graph theory model. The stability of GEDT with Caspase‐6 was studied through molecular dynamic simulation for 100 ns. The adsorption, distribution, metabolism, excretion, and toxicity characteristics of the complex structure were investigated, and the findings revealed the complex lead compound's safety profile and its potential for use as a potent anticancer medication.

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Section: Molecular Docking Studiesmentioning

confidence: 99%

mentioning

confidence: 99%

Exploring the co‐activity of FDA approved drug gemcitabine and docetaxel for enhanced anti‐breast cancer activity: DFT, docking, molecular dynamics simulation and pharmacophore studies

Sukumaran,

Zochedh,

Chandran

et al. 2024

Int J of Quantum Chemistry

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“…Dengan demikian ion logam dapat bertindak sebagai aktivator atau inhibitor. Pada konsentrasi 0-30 mM logam alkali seperti K + ,Na + ,Ca 2+ dan Mg 2+ dapat meningkatan aktivitas pektinase [7]. Akan tetapi pada penelitian Banu et al [8], menyatakan bahwa ion-ion logam dapat mempengaruhi kerja katalitik enzim.…”

Section: No 1 April 2013unclassified

Effect of Metal Ions on Pectinase Activity from Aspergillus niger on Purifying Guava Fruit

Anggraini

Roosdiana

Prasetyawan

et al. 2013

Nat-B

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ABSTRAK ABSTRACTPectinase can be used on various fruit juices clarification, however the activities can be affected by their metal ions content. The purpose of this study was to determine the type of metal ions inhibition i.e. Zn 2+ ; Mg 2+ and Ca 2+ on the pectinase activity of Aspergillus niger, and its potential application in guava juice clarification. Activity assays performed at pH 5, temperature 50°C during 55minutes and each ion concentration were 2-10 mM. Galacturonic acid concentration, as the product of pectin substrate hydrolysis, used as the basis for determining its activity and analyzed by visible spectrophotometry. The results showed that the ions concentration of Zn 2+ and Mg 2+ more than 4 mM were inhibitor for pectinase activity while Ca 2+ ion concentration was 6mM. K I values for the metal ions Zn 2+ ; Mg 2+ and Ca 2+ at concentrations of 6mM were 176.99; 326.09 and 280.37 mM respectively. Pectinase from Aspergillus niger were able to reduce 18% of pectin of guava juice.

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“…Gmelina arborea a deciduous tree belonging to the family Verbenaceae possesses high medicinal properties (Banu et al, 2013). Several studies have revealed Gmelina arborea is an important source of insecticidal botanical.…”

Section: Introductionmentioning

confidence: 99%

Pesticide Potential of Gmelina arborea Stem Bark and Leaf Powder against

John¹,

Ishaya²,

Ihum³

et al. 2022

Nig. J. Biotechnol

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Insect pest are a major problem to food security, most especially in developing countries like Nigeria. There is an urgent need towards mitigating the effects of these group of insects, and botanical extracts had played an increasing role as an alternative insecticide. The aim of the present study is to investigate the anti-feeding effect of different dosage of Gmelina arborea stem bark and leaf powder against Dinoderus porcellus infesting yam chips. The study was conducted at the Entomology Laboratory of Federal College of Forestry, Jos. Soxhlet extraction using methanol was used to extract plant part samples. Presence of phytochemicals contained in the plant were examined following standard protocols. The antifeedant effects of different dosage of Gmelina arborea leaf and stem bark powder on Dinoderus porcellus was determined by monitoring yam chips weight loss. Data collected was subjected to analysis of variance (ANOVA) at 1 % level of significance and the means separated using Duncan test. The results revealed presence of tannin, flavoid, saponins, alkaloids, reducing sugar and phenol with absence of steroid. The results also revealed that the various dosages have remarkable antifeedant effect on the development of D. porcellus. The weight loss of treated yam chips was significantly different from those of untreated yam chips. Therefore, the results obtained in this work accounts for the use of G. arborea plant parts powders as bio-preservative for yam chips against D. porcellus.

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Endophthalmitis Due to Brevibacterium Casei

Cited by 4 publications

References 0 publications

Exploring the co‐activity of FDA approved drug gemcitabine and docetaxel for enhanced anti‐breast cancer activity: DFT, docking, molecular dynamics simulation and pharmacophore studies

Exploring the co‐activity of FDA approved drug gemcitabine and docetaxel for enhanced anti‐breast cancer activity: DFT, docking, molecular dynamics simulation and pharmacophore studies

Effect of Metal Ions on Pectinase Activity from Aspergillus niger on Purifying Guava Fruit

Pesticide Potential of Gmelina arborea Stem Bark and Leaf Powder against

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