Endophthalmitis Caused by &lt;b&gt;&lt;i&gt;Agrobacterium radiobacter&lt;/i&gt;&lt;/b&gt; following Intravitreal Aflibercept for Diabetic Retinopathy

Rohowetz, Landon J.; Yannuzzi, Nicolas A.; Gupta, Sunil; Patel, Nimesh A.; Miller, Darlene; Flynn, Harry W.

doi:10.1159/000505227

Cited by 4 publications

(5 citation statements)

References 32 publications

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“…In 1996, the first case of Rhizobium radiobacter endophthalmitis was reported after cataract surgery [ 42 ] and intravitreous injections [ 45 ]. Few cases have been reported since then [ 33 ]. In our clinic, this is the first confirmed case of R. radiobacter endophthalmitis.…”

Section: Discussionmentioning

confidence: 99%

“…The reported cases of ocular R. radiobacter infections occurred after traumatic medical procedures involving the eye, such as cataract surgery [ 42 ] or intravitreal injections [ 33 ]. Our patient, however, developed endophthalmitis after eye trauma caused by a plant leaf.…”

Section: Discussionmentioning

confidence: 99%

“…Rohowetz et al [ 33 ] reported endophthalmitis with R. radiobacter in a 79–year-old male patient with type II diabetes mellitus and diabetic retinopathy, who received treatment with intravitreal aflibercept. The patient was treated empirically with intravitreal injections of ceftazidime and vancomycin.…”

Section: Systematic Reviewmentioning

confidence: 99%

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A Rare Case of Endophthalmitis with Rhizobium radiobacter, Soon after a Resolved Keratitis: Case Report

et al. 2022

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Background: Rhizobium (Agrobacterium) species are plant aerobic bacteria, which in some cases can produce endophthalmitis in humans after corneal trauma. Case presentation: A 42-year-old female patient presented in the Emergency Department of the Emergency County Hospital of Craiova, Romania, reporting pain, epiphora, and blurry vision in her right eye for about five days. This initial infectious keratitis episode was successfully resolved, but after 20 days she presented again after trauma with a leaf with corneal abscess. In the conjunctival secretion, R. radiobacter was identified. Despite antibiotherapy, the patient’s state did not improve, and ultimately the eye was eviscerated. Methods: A search was performed in the ProQuest, PubMed, and ScienceDirect databases for the terms Agrobacterium, Rhizobium, radiobacter, and eye. We eliminated non-human studies, editorials and commentaries, and non-relevant content, and excluded the duplicates. Results: In total, 138 studies were initially obtained, and then we selected 26 studies for retrieval. After the selection process, we ended up including 17 studies in our analysis. Most studies reported R. radiobacter endophthalmitis after ocular surgical procedures or outdoor activities that involve exposure to soil. Conclusion: R. radiobacter is a rare cause of endophthalmitis after eye trauma that generally responds well to usual antibiotherapy, but occasionally can evolve to severe, leading to the loss of the eye.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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A Rare Case of Endophthalmitis with Rhizobium radiobacter, Soon after a Resolved Keratitis: Case Report

et al. 2022

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“…A. radiobacter is a soil-dwelling organism that rarely causes endophthalmitis and has not been previously reported in association with GDI surgery [ 5 ]. Endophthalmitis secondary to A. radiobacter presents similarly to other causes of endophthalmitis, with decreased visual acuity, pain, and hypopyon as common symptoms [ 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 ]. The organism can be isolated after 2–3 days on MacConkey agar or blood-enriched media and is frequently resistant to empiric intravitreal antibiotics such as vancomycin, ceftazidime, and amikacin, possibly due to its coexistence with antibiotic-producing organisms in soil [ 5 , 9 , 14 , 15 , 16 ].…”

Section: Discussionmentioning

confidence: 99%

“…Agrobacterium (Rhizobium) radiobacter is a Gram-negative bacillus commonly found in soil [ 5 ]. Endophthalmitis due to A. radiobacter is rare but has been reported after cataract surgery and intravitreal injection [ 6 , 7 ]. In this report, we describe a pseudophakic patient with A. radiobacter endophthalmitis secondary to an exposed Baerveldt tube and discuss the treatment which involved pars plana vitrectomy (PPV) and removal of both implants.…”

Section: Introductionmentioning

confidence: 99%

Agrobacterium radiobacter Endophthalmitis Associated with Baerveldt Tube Exposure

Rohowetz¹,

Patel²,

Quan³

et al. 2021

Case Rep Ophthalmol

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Agrobacterium radiobacter is a Gram-negative bacillus and a rare cause of endophthalmitis. An 85-year-male presented with late-onset endophthalmitis associated with exposure of an inferonasal Baerveldt tube. The patient was initially treated with anterior chamber paracentesis and intravitreal antibiotics. Aqueous humor culture revealed A. radiobacter resistant to cefazolin, ceftazidime, amikacin, tobramycin, and trimethoprim-sulfamethoxazole. Subsequently, the patient underwent explantation of the glaucoma drainage implant (GDI). After initial improvement, the patient had clinical worsening and was diagnosed with recurrence. Subsequent treatment involved explantation of the second GDI in addition to pars plana vitrectomy with silicone oil infusion, intraocular lens removal, and administration of intravitreal antibiotics. Visual acuity improved but remained at count fingers at 2 weeks. This is the first reported patient with A. radiobacter endophthalmitis associated with an exposed GDI. This report illustrates the resistant nature of this organism in addition to the efficacy of silicone oil administration and intraocular prosthesis explantation.

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Endophthalmitis Caused by <b><i>Agrobacterium radiobacter</i></b> following Intravitreal Aflibercept for Diabetic Retinopathy

Cited by 4 publications

References 32 publications

A Rare Case of Endophthalmitis with Rhizobium radiobacter, Soon after a Resolved Keratitis: Case Report

A Rare Case of Endophthalmitis with Rhizobium radiobacter, Soon after a Resolved Keratitis: Case Report

<b><i>Agrobacterium radiobacter</i></b> Endophthalmitis Associated with Baerveldt Tube Exposure

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