Endophthalmitis After Intravitreal Injections

Schimel, Andrew M.

doi:10.1001/archophthalmol.2011.370

Cited by 29 publications

(11 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The use of face masks during intravitreal injections may be helpful, although discouraging talking may be similarly helpful. There is no current consensus regarding face masks, and they should not be considered standard practice at this time [48], although there does not appear to be any risk associated with their use. In contrast, it is becoming increasingly apparent that topical antibiotics do not reduce the rate of endophthalmitis following intravitreal anti-VEGF agents and that antisepsis, rather than topical antibiotics, is a preferred practice [49].…”

Section: Discussionmentioning

confidence: 99%

Endophthalmitis Associated with Intravitreal Anti-Vascular Endothelial Growth Factor Injections

Schwartz

Flynn

2013

Curr Ophthalmol Rep

View full text Add to dashboard Cite

The use of anti-vascular endothelial growth factor (VEGF) agents has led to a dramatic increase in the number of intravitreal injections. Endophthalmitis remains a rare but potentially vision-threatening complication of intravitreal injections. Recent large series have estimated this risk to be about one in 3,000 injections or less. Bevacizumab, which is generally prepared by a compounding pharmacy, is associated with additional risks of contamination. Although endophthalmitis cannot be prevented in all cases, certain risk reduction strategies have been proposed, including the use of an eyelid speculum, povidone iodine, avoidance of needle contact with the eyelid margin or eyelashes, and avoidance of routine post-injection antibiotics. Despite these precautions, some patients will develop endophthalmitis following intravitreal anti-VEGF injections, and outcomes may be poor despite prompt and appropriate therapy.

show abstract

Section: Discussionmentioning

confidence: 99%

Endophthalmitis Associated with Intravitreal Anti-Vascular Endothelial Growth Factor Injections

Schwartz

Flynn

2013

Curr Ophthalmol Rep

View full text Add to dashboard Cite

show abstract

“…In an editorial of 2011, Schimel et al [142] concluded that an adequate decrease in bacterial dispersal would conceptionally require the nurse or technician doing the preparation, the physician administering the IVI, and the patient to wear a face mask, which is linked to increased costs and a substantial practical burden.…”

Section: Peri- /Injection Management In Intravitreal Pharmacotherapymentioning

confidence: 99%

2018 Update on Intravitreal Injections: Euretina Expert Consensus Recommendations

et al. 2018

View full text Add to dashboard Cite

Intravitreal injections (IVI) have become the most common intraocular procedure worldwide with increasing numbers every year. The article presents the most up-to-date review on IVI epidemiology and techniques. Unfortunately, important issues related to pre-, peri- and postinjection management lack randomized clinical trials for a final conclusion. Also, a great diversity of approaches exists worldwide. Therefore, expert consensus recommendations on IVI techniques are provided.

show abstract

“… 90 The routine use of surgical masks during intravitreal injections is logical 181 but has not been reported to reduce endophthalmitis rates. 182 The use of lid speculums has been traditionally recommended as part of a sterile protocol for administrating intravitreal injections. 74 , 183 However, one series reported omitting lid speculums did not increase the rate of postinjection endophthalmitis.…”

Section: Prophylaxis Of Endophthalmitismentioning

confidence: 99%

Endophthalmitis: state of the art

Vaziri¹,

Schwartz²,

Kishor³

et al. 2015

OPTH

View full text Add to dashboard Cite

Endophthalmitis is an uncommon diagnosis but can have devastating visual outcomes. Endophthalmitis may be endogenous or exogenous. Exogenous endophthalmitis is caused by introduction of pathogens through mechanisms such as ocular surgery, open-globe trauma, and intravitreal injections. Endogenous endophthalmitis occurs as a result of hematogenous spread of bacteria or fungi into the eye. These categories of endophthalmitis have different risk factors and causative pathogens, and thus require different diagnostic, prevention, and treatment strategies. Novel diagnostic techniques such as real-time polymerase chain reaction (RT-PCR) have been reported to provide improved diagnostic results over traditional culture techniques and may have a more expanded role in the future. While the role of povidone-iodine in prophylaxis of postoperative endophthalmitis is established, there remains controversy with regard to the effectiveness of other measures, including prophylactic antibiotics. The Endophthalmitis Vitrectomy Study (EVS) has provided us with valuable treatment guidelines. However, these guidelines cannot be directly applied to all categories of endophthalmitis, highlighting the need for continued research into attaining improved treatment outcomes.

show abstract

Endophthalmitis After Intravitreal Injections

Cited by 29 publications

References 12 publications

Endophthalmitis Associated with Intravitreal Anti-Vascular Endothelial Growth Factor Injections

Endophthalmitis Associated with Intravitreal Anti-Vascular Endothelial Growth Factor Injections

2018 Update on Intravitreal Injections: Euretina Expert Consensus Recommendations

Endophthalmitis: state of the art

Contact Info

Product

Resources

About