“…To achieve this, cells have developed evolutionary conserved mechanosensitive tools to mediate mechanotransduction [13]. Mechanosensitive ion channels are critical effectors of mechanosignaling and they are mostly associated with regulation of intracellular concentration of calcium ions, as it has been documented for Piezo and transient receptor potential (TRP) families of ion channels [1,13,14]. Mechanosignaling-associated elements include mechanosensitive receptors and membrane-bound proteins like integrins, G proteincoupled receptors (GPCRs), cadherins, focal adhesion kinase (FAK), and Src kinases [2].…”