Endopeptidase 24.11 inhibition does not modify uterotonic effects of endothelins in rat uterus

Kousides, Maria; Story, Margot E; Pennefather, Jocelyn N.

doi:10.1016/s0196-9781(98)00105-3

Cited by 1 publication

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“…The ETA receptors are predominantly localized in rat myometrium (64), and ETA-mediated myometrial contractions have indeed been demonstrated (65,66). Furthermore, uterotonic responses were inhibited by the ETA receptor antagonist BQ 123 , but not by the ETB receptor antagonist BQ 788 (67). Utilization of selective antagonists to ETA and ETB receptors recently implied the involvement of endothelin in hypoxia-induced uteroplacental pathophysiology (68,69).…”

Section: Discussionmentioning

confidence: 97%

Cloprostenol, a prostaglandin F_2α analog, induces hypoxia in rat placenta: BOLD contrast MRI

et al. 2006

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Blood oxygen level dependent (BOLD) contrast was used to monitor hypoxia induced by cloprostenol, a prostaglandin F(2alpha) (PGF(2alpha)) analog, in the rat embryo-placental unit (EPU). It is shown that administration of cloprostenol (0.025 mg/rat) at mid-gestation (day 16) reduced EPU oxygenation, as detected by BOLD contrast MRI, in correlation with induction of vascular endothelial growth factor (VEGF) gene (Vegfa) expression in the corresponding placenta (r = 0.56, p = 0.03). Elevated VEGF mRNA expression in response to cloprostenol treatment was also observed at early gestation (day 9) in the forming placenta (p = 0.04) and uterus (p = 0.03). Cloprostenol increased the expression levels of endothelin-1 (ET-1) gene (Edn1) (p = 0.03) and its corresponding peptide (p = 0.02) in the forming placenta, as well as the expression of the endothelin receptor type A (ETA) gene (Ednra) in both the forming placenta (p = 0.009) and the uterus (p = 0.01). The levels of the endothelin receptor type B (ETB) gene (Ednrb) were not affected in response to cloprostenol, but a significant elevation in the expression level of this receptor was observed in the uterus at mid- and late gestation (day 22) (p = 0.04 and 0.01 respectively), suggesting a role for ETB in the vasodilatory status of the pregnant uterus. It is suggested that PGF(2alpha) induces uteroplacental vasoconstriction in the rat, and that ET-1 may take part in mediating this effect, probably via activation of ETA receptor. The uteroplacental vasoconstriction induces hypoxia, as manifested by significant changes in BOLD MRI and by upregulation of VEGF.

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Section: Discussionmentioning

confidence: 97%

Cloprostenol, a prostaglandin F_2α analog, induces hypoxia in rat placenta: BOLD contrast MRI

et al. 2006

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Endopeptidase 24.11 inhibition does not modify uterotonic effects of endothelins in rat uterus

Cited by 1 publication

References 37 publications

Cloprostenol, a prostaglandin F_2α analog, induces hypoxia in rat placenta: BOLD contrast MRI

Cloprostenol, a prostaglandin F_2α analog, induces hypoxia in rat placenta: BOLD contrast MRI

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Endopeptidase 24.11 inhibition does not modify uterotonic effects of endothelins in rat uterus

Cited by 1 publication

References 37 publications

Cloprostenol, a prostaglandin F2α analog, induces hypoxia in rat placenta: BOLD contrast MRI

Cloprostenol, a prostaglandin F2α analog, induces hypoxia in rat placenta: BOLD contrast MRI

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Cloprostenol, a prostaglandin F_2α analog, induces hypoxia in rat placenta: BOLD contrast MRI

Cloprostenol, a prostaglandin F_2α analog, induces hypoxia in rat placenta: BOLD contrast MRI