Endoneural metastasis of the sciatic nerve disclosing the relapse of a renal carcinoma, four years after its surgical treatment

Varin, Stéphane; Faure, A.; Bouc, Pascal; Maugars, Yves; Berthelot, Jean‐Marie

doi:10.1016/j.jbspin.2006.01.028

Cited by 15 publications

(9 citation statements)

References 7 publications

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“…Intraneural metastasis from carcinoma is extremely rare. A few cases were reported including mammary carcinoma [4], lymphoma [4], renal carcinoma [5], and melanoma [6]. To the best of our knowledge, this report is the first description of a case of sciatic nerve palsy due to intraneural metastasis of gastric carcinoma.…”

Section: Discussionmentioning

confidence: 97%

Intraneural metastasis of gastric carcinoma leads to sciatic nerve palsy

et al. 2012

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BackgroundSoft tissue metastases, in particular intraneural metastasis, from any carcinomas seldom occur. To our knowledge, no case of sciatic nerve palsy due to intraneural metastasis of gastric carcinoma is reported in the literature.Case presentationA case is reported of a 82-year old woman with sciatic nerve palsy with intraneural metastasis of gastric carcinoma. Although she had undergone partial gastrectomy with T2b, N0, M0 two years ago and primary site was cured, she developed sciatic nerve palsy from the carcinoma metastasis directly to the nerve. Operative resection and Histological examination revealed poorly differentiated adenocarcinoma, the same as her primary site adenocarcinoma.ConclusionsSciatica is usually caused by a herniated disc or spinal canal stenosis. Sciatic nerve palsy may be caused by nondiscogenic etiologies that may be either intrapelvic or extrapelvic. It is important to image the entire course of the nerve to distinguish these etiologies quickly. The longer the nerve compression the less likely a palsy will recover. Surgery is a good intervention that simultaneously obtains a tissue diagnosis and decompresses the nerve.

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Section: Discussionmentioning

confidence: 97%

Intraneural metastasis of gastric carcinoma leads to sciatic nerve palsy

et al. 2012

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“…6 Case reports of solid tumor invasion of the more distal peripheral nervous system causing mononeuropathies are scarce. 7,24 Endoneural RCC has been documented in the cauda equina, 8,13 lumbosacral nerve roots, 4,18 and the sciatic nerve. 24 Neurolymphomatoses of the upper extremity have been reported on a few occasions, involving the brachial plexus trunk, 1 radial nerve at the level of the arm, 22 and Note.…”

Section: Discussionmentioning

confidence: 99%

“…12 Descriptions of endoneural solid tumor metastases to the nerves of the upper extremity, in contrast, are more rare, and include the brachial plexus trunk, 14 and a case of carcinoid metastasis to the ipsilateral musculocutaneous and proximal ulnar nerves. 7 Endoneural metastasis from renal cell carcinoma (RCC) has been shown to occur in the cauda equina, 8,13 lumbosacral nerve roots, 4,18 and the sciatic nerve 24 ; however, descriptions of RCC invasion of upper extremity nerves are absent.…”

Section: Introductionmentioning

confidence: 99%

Interfascicular Renal Cell Carcinoma Metastasis to the Ulnar Nerve

Humphries

Baluch

Nystrom

et al. 2016

Hand (New York, N,Y.)

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“…1,9 Peripheral endoneural metastases of RCC have also been diagnosed up to 4 years after surgical removal of the primary tumor. 12 Although rare, the incidences of cervical, thoracic, and lumbar tumors are equal, with sacral lesions being less common. 1,13 …”

Section: Discussionmentioning

confidence: 99%

Surgical treatment options and management strategies of metastatic renal cell carcinoma to the lumbar spinal nerve roots

Strong

Yanamadala

Khanna

et al. 2013

Journal of Clinical Neuroscience

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Spinal nerve root metastasis of renal cell carcinoma is a rare occurrence. In addition to treatment of the primary lesion, surgical resection of the nerve root metastasis, occasionally with sacrifice of the involved nerve, is the accepted standard of treatment. Resection often resolves presenting motor and pain symptoms due to relief of neural compression. We describe two patients with nerve root metastasis of renal cell carcinoma and their management. While locally advanced and metastatic renal cell carcinoma has been shown to be chemo- and radio-resistant, immunotherapy is a promising treatment. Given the high prevalence of systemic disease in patients with intradural metastases, systemic (and possibly intracranial) imaging can be used to identify other potential areas of disease.

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Endoneural metastasis of the sciatic nerve disclosing the relapse of a renal carcinoma, four years after its surgical treatment

Cited by 15 publications

References 7 publications

Intraneural metastasis of gastric carcinoma leads to sciatic nerve palsy

Intraneural metastasis of gastric carcinoma leads to sciatic nerve palsy

Interfascicular Renal Cell Carcinoma Metastasis to the Ulnar Nerve

Surgical treatment options and management strategies of metastatic renal cell carcinoma to the lumbar spinal nerve roots

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