Endometriosis: What is the Influence of Immune Cells?

Crispim, Paula Carolina Arvelos; Jammal, Millena Prata; Murta, Eddie Fernando Cândido; Nomelini, Rosekeila Simões

doi:10.1080/08820139.2020.1764577

Cited by 20 publications

(14 citation statements)

References 85 publications

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“…According to current research, it is likely that immunological changes play a role in the development of endometriosis. 39 The reason why almost one in two endometriosis patients believed that the immune system was involved in the development of their illness might be due to the fact that this knowledge is spreading among patients. According to a paper on the coverage of endometriosis in the press, endometriosis is frequently associated with autoimmune diseases and environmental pollutants in women’s magazines.…”

Section: Discussionmentioning

confidence: 99%

Subjective theories of illness in fibroid and endometriosis patients: Similarities, differences, and influencing factors

Münch

Ebert²,

Mechsner

et al. 2022

Journal of Endometriosis and Pelvic Pain Disorders

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Introduction: The aim of this study was to compare the subjective theories of illness in patients with fibroids and patients with endometriosis, and to identify potential factors influencing them. Methodology: Participating patients were recruited via three specialized centers for fibroids and endometriosis. To assess their subjective theories concerning the cause of their illness, we used a questionnaire based on the revised Illness Perceptions Questionnaire (IPQ-R). We also gathered and evaluated data relating to sociodemographic factors and psychological distress or possible anxieties using the Kessler Psychological Distress Scale (K10) and the Generalised Anxiety Disorder Assessment (GAD-7). Results: We were able to analyze data from 201 patients with fibroids and 212 patients with endometriosis. About 94.4% of the patients had one or more subjective theories concerning the cause of their illness. Both groups perceived “stress or worry” to be the most probable cause of their illness. Compared to endometriosis patients, patients with fibroids were more likely to assume “aging” and “heredity” as the cause of their illness. Endometriosis patients, on the other hand, were more likely to choose theories pertaining to the “environmental influences and immune system” category. The patients’ age, formal education, and conspicuous score values in the K10 or GAD-7 questionnaire proved to be important factors influencing their beliefs about the cause of illness. Conclusion: Patients perceive stress and psychological strain as possible causes for their illness. It might be beneficial to take this information into account in conversations between doctors and patients and when drawing up psychosomatic-gynecological treatment plans.

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Section: Discussionmentioning

confidence: 99%

Subjective theories of illness in fibroid and endometriosis patients: Similarities, differences, and influencing factors

Münch

Ebert²,

Mechsner

et al. 2022

Journal of Endometriosis and Pelvic Pain Disorders

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“…Consequently, EM-circulating anti-endometrial antibodies could mask endometrial antigens. As a result, endometrial antigens might not be effectively recognized, with lost endometrial fragments remaining, potentially leading to ectopic establishment [ 83 , 88 , 89 ].…”

Section: Endometriosis and Inflammationmentioning

confidence: 99%

“…Aberrant expression of several cytokines by inflammatory cells, such as IL-1, IL-4, IL-6, IL-8, IL-10, IL-33, TNFα and growth factors, e.g., transforming growth factor (TGF-β), insulin-like growth factor (IGF-1), hepatocyte growth factor (HGF), epidermal growth factor (EGF), platelet-derived growth factor (PDGF), and vascular endothelial growth factor (VEGF), have been reported in EM [ 89 , 98 ]. Indeed, cytokines such as IL-8 and TNF-α are known to promote endometrial cell proliferation, endometrial adhesion, and angiogenesis.…”

Section: Endometriosis and Inflammationmentioning

confidence: 99%

Neurogenic Inflammation in the Context of Endometriosis—What Do We Know?

Velho

Taube

Sehouli

et al. 2021

IJMS

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Endometriosis (EM) is an estrogen-dependent disease characterized by the presence of epithelial, stromal, and smooth muscle cells outside the uterine cavity. It is a chronic and debilitating condition affecting ~10% of women. EM is characterized by infertility and pain, such as dysmenorrhea, chronic pelvic pain, dyspareunia, dysuria, and dyschezia. Although EM was first described in 1860, its aetiology and pathogenesis remain uncertain. Recent evidence demonstrates that the peripheral nervous system plays an important role in the pathophysiology of this disease. Sensory nerves, which surround and innervate endometriotic lesions, not only drive the chronic and debilitating pain associated with EM but also contribute to a growth phenotype by secreting neurotrophic factors and interacting with surrounding immune cells. Here we review the role that peripheral nerves play in driving and maintaining endometriotic lesions. A better understanding of the role of this system, as well as its interactions with immune cells, will unearth novel disease-relevant pathways and targets, providing new therapeutics and better-tailored treatment options.

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“…These cytokines launch and enhance the inflammatory response, targeting the recruitment of various proinflammatory cells and mediators. Tumor necrosis factor and its receptors, TNFR1 and TNFR2, represent an extrinsic apoptosis pathway involved in endometriosis genesis, being implicated in inflammatory and endometrial repair [ 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

“…The endocrine premature dendritic cells reach maturity and are carried through the lymphatic vessels in response to foreign antigens or various antigens on top of T cells from inflammatory targets. In endometriozic tissues, this physiological process is being modified and the population of CD83+ dendritic cells is significantly decreased, leading to endometrial antigen misrecognition by the circulating antiendometrial stromal cells [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

Prospects and Challenges of the Drug Delivery Systems in Endometriosis Pain Management: Experimental and Theoretical Aspects

Toma

Socolov

Popa

et al. 2021

Journal of Immunology Research

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Endometriosis is considered a serious public health issue because of the large number of females affected by this illness. Chronic pain management in patients with endometriosis demands new strategies to increase the life quality of these patients. The development of drug delivery systems represents a new approach in pain treatment among endometriosis patients. Diclofenac sodium, one of the most utilized nonsteroidal anti-inflammatory drugs (NSAID), has its own limitations when being used in formulas such as oral, parental, or local applications. In this paper, a series of four drug release formulations based on chitosan, 2-hydroxy-5-nitrobenzaldehyde, and diclofenac sodium salt were prepared in view of the investigation of the drug release ability. The formulations were analyzed from a morphological and supramolecular point of view by scanning electron microscopy and polarized light microscopy. The in vitro drug release ability was investigated by mimicking a physiologic environment. A mathematical model, using the fractal paradigm of motion, is utilized to explain the behaviors of the drug delivery system presented in this paper. These results suggest a great potential of the proposed drug delivery system, based on chitosan and 2-hydroxy-5-nitrobenzaldehyde to improve the diclofenac sodium salt bioavailability, and it may represent a future treatment formula for endometriosis pain.

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Endometriosis: What is the Influence of Immune Cells?

Cited by 20 publications

References 85 publications

Subjective theories of illness in fibroid and endometriosis patients: Similarities, differences, and influencing factors

Subjective theories of illness in fibroid and endometriosis patients: Similarities, differences, and influencing factors

Neurogenic Inflammation in the Context of Endometriosis—What Do We Know?

Prospects and Challenges of the Drug Delivery Systems in Endometriosis Pain Management: Experimental and Theoretical Aspects

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