Endometriosis shows no impact on the euploid blastocyst rate per cohort of inseminated metaphase-II oocytes: A case-control study

Vaiarelli, Alberto; Venturella, Roberta; Cimadomo, Danilo; Conforti, Alessandro; Pedri, Sara; Bitonti, Giovanna; Iussig, Benedetta; Gentile, C.; Alviggi, Erminia; Santopaolo, Serena; Zullo, Fulvio; Rienzi, Laura; Ubaldi, Filippo Maria

doi:10.1016/j.ejogrb.2020.11.024

Cited by 10 publications

(5 citation statements)

References 56 publications

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“…In rare cases, endometriosis involves extra-pelvic organs such as the gastrointestinal or urinary tracts [ 6 ]. Clinical manifestations are widely variable among patients and can include dysmenorrhea, chronic pelvic pain, dyspareunia, infertility, and bowel and/or urinary disorders when these organs are involved [ 7 , 8 ]. Several pathogenic hypotheses for endometriosis have been proposed to date [ 9 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

Unravelling the link between phthalate exposure and endometriosis in humans: a systematic review and meta-analysis of the literature

Conforti

Carbone

Simeon

et al. 2021

J Assist Reprod Genet

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Purpose Endometriosis is a chronic debilitating inflammatory pathology which interests females in their reproductive age. Its pathogenesis has not yet been clearly defined. Recent evidence linked chemical agents as endocrine-disrupting chemicals to endometriosis. Phthalates are a widely used class of such compounds. This study aimed to summarize the current literature evaluating the link between exposure to phthalates and occurrence of endometriosis. Methods A systematic review of literature and meta-analysis has been carried out following PRISMA guidelines to assess such link. Fourteen studies have been included in the review. Risk of bias has been assessed through the Newcastle Ottawa Scale. Results We observed association between endometriosis and increased urinary levels of MBP/MnBP, MEOHP, and MEHHP, but not for others. Blood-derived analysis showed statistically significant link between endometriosis and BBP, DEHP, DnBP, and MEHP. Conclusion Given the wide heterogeneity of included studies, results should be taken with caution. Further studies with more rigorous methodology are encouraged to unravel the true link between this class of toxic compounds and manifestation of endometriosis.

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Section: Introductionmentioning

confidence: 99%

Unravelling the link between phthalate exposure and endometriosis in humans: a systematic review and meta-analysis of the literature

Conforti

Carbone

Simeon

et al. 2021

J Assist Reprod Genet

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“…Going further, Vaiarelli and coworkers have evaluated the euploid blastocyst rate per cohort of inseminated metaphase II oocytes [ 47 ]. Affected patients ( n = 210) were matched in a 1:2 ratio to controls ( n = 420) by IVF clinic, maternal age at retrieval, number of previous failed IVF treatments and number of metaphase II oocytes retrieved.…”

Section: Methodsmentioning

confidence: 99%

“…However, in this latter study, the statistical differences between the two groups in terms of total and starting dose of gonadotrophins used and FSH levels, question its absence of confounding factors. In this regard, based on the study design employed, results from Vaiarelli and coworkers seem the most robust [ 47 ].…”

Section: Methodsmentioning

confidence: 99%

Endometriosis and IVF treatment outcomes: unpacking the process

Somigliana,

Li Piani,

Paffoni

et al. 2023

Reprod Biol Endocrinol

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Advanced endometriosis is associated with a reduction of IVF success. Surgical damage to the ovarian reserve following the excision of endometriomas has been claimed as a critical factor in the explanation of this detrimental effect. However, it is generally inferred that other mechanisms might also hamper IVF success in affected women. They include diminished responsiveness to ovarian stimulation, altered steroidogenesis, a decline in oocyte quality, reduced fertilization and embryo development, and impaired implantation. To navigate these limitations, we scrutinized available literature for studies specifically designed to address distinct phases of the IVF process. Utmost consideration was given to intra-patient ovarian response comparisons in women with unilateral endometriomas and to studies applying a meticulous matching to control confounders. The following observations have been drawn: 1) endometriosis has a negligible impact on ovarian response. A slight reduction in stimulation response can only be observed for endometriomas larger than 4 cm. Follicular steroidogenesis is unaffected; 2) oocyte quality is not hampered. Fertilization rates are similar, and intracytoplasmic sperm injection (ICSI) is not justified. Embryonic development is uncompromised, with no increase in aneuploidy rate; 3) endometrial receptivity is either unaffected or only slightly impacted. In conclusion, our study suggests that, aside from the well-known negative effect on ovarian reserve from excisional endometrioma surgeries, endometriosis does not significantly affect IVF outcomes.

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“…No studies have demonstrated a higher rate of aneuploidy in those with endometriosis. [27][28][29] A large study based on data from the Human Fertilisation and Embryology Authority (HFEA) database aimed to address the question of oocyte competence. The study comprised 758 donor oocyte recipients with endometriosis compared with 12 856 autologous IVF cycles in women with endometriosis as the sole cause for infertility.…”

Section: Endometriosis and The Oocyte/embryomentioning

confidence: 99%

“…Several studies have looked at rates of embryo aneuploidy using pre‐implantation genetic testing (PGT‐A) in eggs retrieved from women with a diagnosis of endometriosis and compared aneuploidy rates with couples with other diagnoses for their subfertility. No studies have demonstrated a higher rate of aneuploidy in those with endometriosis 27–29 …”

Section: Endometriosis and The Oocyte/embryomentioning

confidence: 99%

Endometriosis and subfertility

Morris,

Lilly,

Jefferys

et al. 2024

The Obstetric & Gynaecologis

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Key content Medical management of endometriosis is often contraceptive. In contrast, surgical treatment may improve the chance of spontaneous conception. There is conflicting evidence as to whether surgery improves outcomes with assisted conception, and this should be discussed with a specialist in reproductive medicine. Surgery, particularly for ovarian endometriosis, can cause a decreased ovarian reserve and fertility preservation should be considered. There is no standard approach to managing endometriosis in the fertility setting. It is important to take a holistic approach to diagnosis and management of the subfertile couple where endometriosis may be a contributing factor. Learning objectives To understand the mechanisms by which endometriosis can contribute to subfertility. To understand the importance of a comprehensive assessment of the subfertile couple and the important factors that will inform an individualised management plan. To develop a framework for managing endometriosis in the context of subfertility including fertility preservation

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Endometriosis shows no impact on the euploid blastocyst rate per cohort of inseminated metaphase-II oocytes: A case-control study

Cited by 10 publications

References 56 publications

Unravelling the link between phthalate exposure and endometriosis in humans: a systematic review and meta-analysis of the literature

Unravelling the link between phthalate exposure and endometriosis in humans: a systematic review and meta-analysis of the literature

Endometriosis and IVF treatment outcomes: unpacking the process

Endometriosis and subfertility

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