Endometriosis related to family history of malignancies in the Yale series

Matalliotakis, Ioannis; Çakmak, Hakan; Krasonikolakis, Georgios D.; Dermitzaki, Despina; Fragouli, Yvoni; Vlastos, Georges; Arıcı, Aydın

doi:10.1016/j.suronc.2009.02.012

Cited by 15 publications

(8 citation statements)

References 16 publications

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“…Several studies have suggested a familial tendency for endometriosis with a genetic basis (50–52). Furthermore, family history of ovarian cancer and colon cancer is significantly higher in women with endometriosis (53). Genetic linkage analyses have defined several potential candidate genetic loci and genes associated with endometriosis.…”

Section: Endometriosis and Ovarian Cancer: Molecular Geneticsmentioning

confidence: 99%

Endometriosis and Ovarian Cancer

Wei

William

Bulun

2011

International Journal of Gynecological Pathology

151

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Summary Endometriosis is a chronic disease that affects millions of reproductive-age women. Despite the destructive and invasive nature of endometrioses, most cases are perpetually benign or eventually regress; however, atypical endometriosis is a precursor lesion and can lead to certain types of ovarian cancer. Endometriosis induced inflammation and auto- and paracrine production of sex steroid hormones contribute to ovarian tumorigenesis. These changes provide microenvironment necessary to accumulate enough genetic alterations for endometriosis associated malignant transformation. It takes years for endometriosis to undergo the pathophysiological progression that begins with atypical epithelial proliferation (atypical endometriosis and metaplasia), and then is followed by the formation of well-defined borderline tumors, and finally culminates in fully malignant ovarian cancer. This study is a review of the natural history of endometriosis and the role of microenvironments that favor the accumulation of genetic alterations and endometriosis-associated ovarian cancer progression.

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Section: Endometriosis and Ovarian Cancer: Molecular Geneticsmentioning

confidence: 99%

Endometriosis and Ovarian Cancer

Wei

William

Bulun

2011

International Journal of Gynecological Pathology

151

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“…The development of cancer disease induces a host response; numerous inflammatory mediators are secreted and disturb the hemostatic balance, leading to the increase of the blood prothrombotic potential. Additionally, activation of the coagulation system is also enhanced by various factors released from transformed cells [2–4]. The increased synthesis of acute phase proteins (including fibrinogen), stimulation of blood coagulation and activation of extravenous proteolysis are not only phenomena associated with neoplasm, but also an integral mechanism of cancer progression [5, 6].…”

Section: Introductionmentioning

confidence: 99%

Reviews The role of fibrinogen, fibrin and fibrin(ogen) degradation products (FDPs) in tumor progression

Kołodziejczyk¹,

Ponczek²

2013

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Participation of fibrin, fibrinogen, and their degradation products in pathogenesis and progression of cancer may lead to complications of thromboembolic events. The tumor may be a source of fibrinogen. Fibrinogen inside the tumor is one of the factors of its growth and metastasis. Fibrinogen, fibrin and their degradation products possess proinflammatory activity. They indirectly stimulate endothelium to secrete von Willebrand factor, leading to activation of platelets accompanying neoplastic disorders. Fragments E and D are the end products of fibrin(ogen) degradation and E and DD are the end products of stabilized fibrin. E stimulates proliferation, migration and differentiation of endothelial cells, contributing to tumor vasculature. Increased levels of DD are observed in malignant neoplasms, such as breast, lung, colon and ovary cancers. In breast cancers DD correlates with progression of disease and metastasis. The role of fibrinogen and the products of its degradation in the progression of various tumors is not sufficiently understood.

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“…This process is frequently associated with several mechanisms involved in angiogenesis and cellular adhesion. In fact, women who have endometriosis appear to be more at risk of developing several different kinds of ovarian cancers [8,11-13]. An epidemiological study showed that the prevalence rates of endometriosis in patients with endometrioid and clear cell ovarian carcinoma are 19 and 35.9, respectively [14].…”

Section: Introductionmentioning

confidence: 99%

MUC4gene polymorphisms associate with endometriosis development and endometriosis-related infertility

Chang

Hui-Wen

Chen

et al. 2011

BMC Med

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BackgroundMucin 4 (MUC4) plays an important role in protecting and lubricating the epithelial surface of reproductive tracts, but its role in the pathogenesis of endometriosis is largely unknown.MethodsTo correlate MUC4 polymorphism with the risk of endometriosis and endometriosis-related infertility, we performed a case-control study of 140 patients and 150 healthy women. Six unique single-nucleotide polymorphisms (SNPs) (rs882605, rs1104760, rs2688513, rs2246901, rs2258447 and rs2291652) were selected for this study. DNA fragments containing the target SNP sites were amplified by polymerase chain reaction using the TaqMan SNP Genotyping Assay System to evaluate allele frequency and distribution of genotype in MUC4 polymorphisms.ResultsBoth the T/G genotype of rs882605 and the frequency of haplotype T-T (rs882605 and rs1104760) were higher in patients than in controls and were statistically significant. The frequency of the C allele at rs1104760, the C allele at rs2688513, the G allele at rs2246901 and the A allele at rs2258447 were associated with advanced stage of endometriosis. Moreover, the G allele at rs882605 was verified as a key genetic factor for infertility in patients. Protein sequence analysis indicated that amino acid substitutions by genetic variations at rs882605, rs2688513 and rs2246901 occur in the putative functional loops and the type D von Willebrand factor (VWFD) domain in the MUC4 sequence.ConclusionsMUC4 polymorphisms are associated with endometriosis development and endometriosis-related infertility in the Taiwanese population.

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Endometriosis related to family history of malignancies in the Yale series

Cited by 15 publications

References 16 publications

Endometriosis and Ovarian Cancer

Endometriosis and Ovarian Cancer

Reviews The role of fibrinogen, fibrin and fibrin(ogen) degradation products (FDPs) in tumor progression

MUC4gene polymorphisms associate with endometriosis development and endometriosis-related infertility

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