Endometriosis, especially mild disease: a risk factor for miscarriages

Schwartz, A Kohl; Wölfler, M; Mitter, Vera; Rauchfuß, Martina; Haeberlin, Felix; Eberhard, Markus; Orelli, Stephanie von; Imthurn, Bruno; Imesch, Patrick; Fink, Daniel; Leeners, Brigitte

doi:10.1016/j.fertnstert.2017.08.025

Cited by 52 publications

(36 citation statements)

References 66 publications

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“…This association could be related to a genotoxic effect on the oocyte induced by the iron content in the endometrioma fluid [19]. Schwartz et al reported a higher miscarriage rate in patients with mild endometriosis, as superficial lesions provoke severe inflammation, possibly leading to defective folliculogenesis, fertilization, and/or implantation [27]. A retrospective cohort study thus showed a higher miscarriage rate in all types of endometriosis (superficial, endometrioma, DIE) compared to the healthy controls [28].…”

Section: Discussionmentioning

confidence: 99%

Endometriosis and Pregnancy: A Single Institution Experience

Porpora

Tomao

Ticino

et al. 2020

IJERPH

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Endometriosis may compromise the physiological course of pregnancy. The aim of this prospective observational study was to evaluate whether endometriosis causes a higher prevalence of obstetric and neonatal complications as well as a higher risk of caesarean section and to detect a possible correlation between the presence, type, and location of endometriosis and obstetric complications, previous surgery, and pregnancy outcome, as well as the influence of pregnancy on the course of the disease. We compared two cohorts of women with spontaneous pregnancy, with and without endometriosis. Obstetric and neonatal outcomes, mode of delivery, presence, type, and location of endometriotic lesions and the effect of pregnancy on the disease were analyzed. A total of 425 pregnancies were evaluated: 145 cases and 280 controls. Patients with endometriosis showed a higher incidence of miscarriage, threatened miscarriage, threatened preterm labor, preterm delivery, placental abruption, and a higher incidence of caesarean section. A significant correlation with pregnancy-induced hypertension and preeclampsia was found in the presence of adenomyosis. No difference in fetal outcome was found. One case of hemoperitoneum during pregnancy was observed. Pregnancy in women with endometriosis carries a higher risk of obstetric complications, such as miscarriage, threatened miscarriage, preterm labor, preterm birth, and a higher caesarean section rate. Endometriosis does not seem to influence fetal well-being.

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Section: Discussionmentioning

confidence: 99%

Endometriosis and Pregnancy: A Single Institution Experience

Porpora

Tomao

Ticino

et al. 2020

IJERPH

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“…The similar findings were achieved by other scientists. In the course of independent studies, they concluded that patients with endometriosisassociated infertility undergoing IVF reflect with a significantly reduced level of all markers of the reproductive function, resulting in a lower pregnancy rate than in the control group [7][8][9][10][11] ( Table 2).…”

Section: Resultsmentioning

confidence: 99%

Implantation failures in women with infertility associated endometriosis

Radzinsky

Оразов

Ivanov

et al. 2019

Gynecological Endocrinology

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Endometriosis is currently considered as one of the most common diseases associated with infertility. A controversial issue is whether endometriosis per se exerts a detrimental effect on IVF outcomes. Failure of implantation due to endometriosis-associated infertility is a contradictory and widely discussed burden nowadays. The purpose of the study is to assess the quality of embryos and implantation rate in women with infertility associated with endometriosis. The study included infertile reproductive aged women, between 26 and 40 years who underwent IVF and ICSI procedures. The patients were divided into two groups: group I (n ¼ 70) involved 70 patients with recurrent unilateral endometriomas, II control group (n ¼ 50) with tubal factor infertility. The quality of the retrieved embryos was assessed according to the generally accepted classification of Gardner, indicating the rate of implantation in each group. Embryo transfer was performed in case of high quality embryos. Assessing the ovarian reserve indicators, in the group I patients with recurrent unilateral endometriomas the serum level of AMH was significantly lower (2.1 ± 1.75 vs. 3.2 ± 1.4, p < .005), as well as the number of retrieved oocytes (8.1 ± 3.9 and 10.1 ± 6.8, p < .005). The analysis of the results demonstrated that the duration of stimulation in the group patients with recurrent unilateral endometriomas was significantly higher in comparison with the group II (12.2 ± 1.8 and 10.2 ± 1.6 days, p < .001). Nevertheless, the number of good quality embryos retrieved was comparable in both groups (2.2 ± 1.5 and 2.8 ± 1.8). In the group I patients with recurrent unilateral endometriomas, there was a statistically significant decrease of implantation rate (17.1% vs. 24% p < .005). The results of the study revealed no statistical difference in embryo quality in the study cohort. However, it is important to note that a statistically significant difference in implantation rate in the group of endometriosis-associated infertility compared was obtained 1.5 times lower than in the control group (15.8% vs. 24.0% p < .005). The achieved results demonstrated an adverse IVF outcome in infertile women with recurrent endometrioma compared to the control group.

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“…Endometriosis, which is described as the presence of endometrial gland and stroma outside the uterine cavity, is an important women’s health problem seen in 6–10% of women that causes degradation in the quality of life with clinical effects, such as infertility, dysmenorrhea, dyspareunia and chronic pelvic pain 1–4 . Its pathophysiology has not yet been fully resolved, and an effective treatment for it has not yet been found 5,6 .…”

Section: Introductionmentioning

confidence: 99%

The Effects of Leukocyte- and Platelet-Rich Plasma (L-Prp) and Pure Platelet-Rich Plasma (P-Prp) an a Rat Endometriosis Model

Anğın

Gün

Sakin

et al. 2019

Preprint

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29Our aim was to investigate the effect of platelet-rich plasma (PRP) derivatives, which 30 can be produced from the patient's own blood and have minimal side effects, on 31 endometriosis. To the best of our knowledge, this is the first study in the literature that studies 32 the relationship between PRP and endometriosis. Endometriosis foci were created in the first 33 operation. In the second operation (30 th day) groups were formed. Group 1 (n= 8) was 34 administered saline, group 2 (n= 7) leukocyte-and platelet-rich plasma (L-PRP), and group 3 35 (n= 8) pure platelet-rich plasma (P-PRP). Group 4 (n= 10) was used to obtain PRP. In the last 36 operation (60 th day), the endometriotic foci were measured, and then excised. There was no 37 statistically significant difference between the pre and post volumes of the endometriotic foci, 38 between their volume differences and volume difference rates (p > .05). However, it was 39 observed that existing implant volumes in all groups decreased statistically significantly 40 within their own groups by the end of the experiment compared to the previous volumes (p < 41 .05). When the implants were assessed through histopathological scoring in terms of edema, 42 vascular congestion, inflammatory cell infiltration, hemorrhage, epithelial line, and 43 hemosiderin accumulation and immunohistochemical staining in terms of VEGF, there was 44 no significant difference in the comparison between the groups. Although L-PRP and P-PRP 45 generated more reduction in the endometriosis foci, they did not create any statistical 46 differences. 48Endometriosis, which is described as the presence of endometrial gland and stroma 49 outside the uterine cavity, is an important women's health problem seen in 6-10% of women 50 that causes degradation in the quality of life with clinical effects, such as infertility, 3 51 dysmenorrhea, dyspareunia and chronic pelvic pain 1-4 . Its pathophysiology has not yet been 52 fully resolved, and an effective treatment for it has not yet been found 5,6 . 53

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Endometriosis, especially mild disease: a risk factor for miscarriages

Abstract: NCT02511626.

Cited by 52 publications

References 66 publications

Endometriosis and Pregnancy: A Single Institution Experience

Endometriosis and Pregnancy: A Single Institution Experience

Implantation failures in women with infertility associated endometriosis

The Effects of Leukocyte- and Platelet-Rich Plasma (L-Prp) and Pure Platelet-Rich Plasma (P-Prp) an a Rat Endometriosis Model

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