Endometriosis does not impact live-birth rates in frozen embryo transfers of euploid blastocysts

Bishop, L.A.; Gunn, Justin C.; Jahandideh, Samad; Devine, Kate; DeCherney, Alan H.; Hill, Micah J.

doi:10.1016/j.fertnstert.2020.07.050

Cited by 49 publications

(39 citation statements)

References 27 publications

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“…Endometrial alterations encountered in endometriosis appear to be corrected in cases of blockage of ovarian function, including in E2 and progesterone cycles prescribed for timing frozen embryo transfers (FET). In support of the latter, Bishop et al (9) observed no differences in pregnancy outcomes in case of FET of euploid blastocysts in patients with endometriosis as compared with their counterparts undergoing ART for male factor infertility. Based on these findings, one currently recommends to offer a freeze all and deferred embryo transfer strategy in case of endometriosis (68), an approach not increasing the risk of endometriosis flare (69).…”

Section: Endometriosis and Early Pregnancy Losses: What Is The Evidence?mentioning

confidence: 90%

“…However, more recent results on the impact of endometriosis on ART outcome often draw contradictory conclusions on these topics (7). Indeed, some reports show equal outcome in case of endometriosis in terms of embryo euploidy (8) and implantation rates (9), as compared with disease-free controls. As discussed later in this article, the differences on the impact of endometriosis on fertility mainly depend on whether pregnancies occur naturally (in vivo) or through ART, with recent reports showing little impact in the latter case.…”

Section: Endometriosis Adenomyosis and Rpl Endometriosismentioning

confidence: 99%

“…Actual obstetric complications encountered in cases of endometriosis. The risk of obstetric complications in cases of endometriosis was reported widely recently (78)(79)(80)(81), although some studies fail to find such links (9,(82)(83)(84)(85). Also, the incidence of endometriosis may be associated with genetic or lifestyle factors, which are likewise associated with a higher pregnancy loss (e.g., smoking) (12, 13, 86, 87).…”

Section: Endometriosis and Early Pregnancy Losses: What Is The Evidence?mentioning

confidence: 99%

See 2 more Smart Citations

Endometrial causes of recurrent pregnancy losses: endometriosis, adenomyosis, and chronic endometritis

Pirtea

Cicinelli

Nola

et al. 2021

Fertility and Sterility

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Chronic inflammatory processes affecting the endometrium, as encountered in endometriosis, adenomyosis, and chronic endometritis, alter endometrial receptivity. These disorders are associated with early pregnancy losses and possibly recurrent pregnancy losses (RPL). In the cases of endometriosis, other factors associated with the disease also are susceptible of causing miscarriages and possibly RPL, such as an impact of intrapelvic inflammatory processes affecting the oocyte and embryo in case of natural conception. Conversely these latter effects obviously are bypassed in case of assisted reproductive technology. Chronic inflammation of the endometrium in the condition known as chronic endometritis also causes early pregnancy losses and RPL with beneficial effects achieved when specific treatment is undertaken. (Fertil Steril Ò 2021;115:546-60. Ó2020 by American Society for Reproductive Medicine.

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Section: Endometriosis and Early Pregnancy Losses: What Is The Evidence?mentioning

confidence: 90%

Section: Endometriosis Adenomyosis and Rpl Endometriosismentioning

confidence: 99%

Section: Endometriosis and Early Pregnancy Losses: What Is The Evidence?mentioning

confidence: 99%

See 1 more Smart Citation

Endometrial causes of recurrent pregnancy losses: endometriosis, adenomyosis, and chronic endometritis

Pirtea

Cicinelli

Nola

et al. 2021

Fertility and Sterility

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show abstract

“…Це може бути зниження якості ооцитів або рецептивності ендометрія. Доведено, що використання контролю якості кріоконсервованих ембріонів дозволяє запобігти можливому негативному впливу ендометріозу на наслідки вагітності [2].…”

Section: д и с т а н ц і й н е н а в ч а н н яunclassified

The peculiarities of the management of women with endometriosis during pregnancy

Лахно

2021

RHW

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Endometriosis is a significant problem in modern medicine. The prevalence of endometriosis is 10%, it occurs in 38% of women with infertility. For a century, it was believed that pregnancy contributes to the reduction in volume and even the disappearance of foci of endometriosis. Also, the state of «pseudopregnancy» under the influence of combined oral contraceptives was once considered an effective treatment strategy. To date, it is known that decidualization of endometrioid heterotopias not only contributes to their increase in size, but can also provoke bleeding. These changes can mimic ovarian cancer on ultrasonography. Typical complications of endometriosis are enlargement, rupture, or abscess formation.It has been proven that women with endometriosis have an increased relative risk of developing: preeclampsia by 19%; fetal growth retardation by 12%; premature birth by 46%; placenta previa almost threefold; preterm placental abruption by 40%; caesarean section operations by 49%; stillbirth by 27%; postpartum hemorrhage by 5%; spontaneous intra-abdominal bleeding by 24.6 times – only two cases are known in women with endometriosis and no bleeding from the intact peritoneum is known; spontaneous bowel perforation (only 18 cases are known). It has been proven that in pregnant women with endometriosis, the invasion of the extravillous trophoblast into the spiral vessels of the uterus is impaired. However, there is evidence that the endometrioid phenotype is not associated with placental dysfunction and does not increase the risk of developing great obstetric syndromes.Since most of the complications of endometriosis during pregnancy cannot be predicted, any additional interventions are not of use. So, to date, there is no evidence of the need to introduce separate protocols for the management of women with endometriosis during pregnancy. However, there should be an individualization of the approach in each separate case. The given atypical clinical case in a woman with diffuse adenomyosis demonstrates the importance of the problem of predicting various complications of pregnancy and childbirth. Moreover, clinical cases contribute to the continuation of the study of this disease.

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“…The observation is of paramount importance for understanding the proper management of infertile women suffering of endometriosis. The observation of Bishop et al (5) indicates that endometrial receptivity is normal when the precaution is taken to suppress ovarian function with estradiol (E 2 ) and intramuscular progesterone before embryo transfer. Therefore the effects of E 2 and intramuscular progesterone treatment are similar to that previously reported after ovarian suppression with the oral contraceptive pill or a gonadotropin-releasing hormone agonist.…”

mentioning

confidence: 99%

Effects of endometriosis on assisted reproductive technology: gone with the wind

Pirtea

Ziegler

Ayoubi

2021

Fertility and Sterility

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Endometriosis does not impact live-birth rates in frozen embryo transfers of euploid blastocysts

Cited by 49 publications

References 27 publications

Endometrial causes of recurrent pregnancy losses: endometriosis, adenomyosis, and chronic endometritis

Endometrial causes of recurrent pregnancy losses: endometriosis, adenomyosis, and chronic endometritis

The peculiarities of the management of women with endometriosis during pregnancy

Effects of endometriosis on assisted reproductive technology: gone with the wind

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