2009
DOI: 10.1258/mi.2009.009041
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Endometriosis: associations with menopause, hormone replacement therapy and cancer

Abstract: Endometriosis is an estrogen-dependent condition and is characterized by the presence of ectopic endometrial tissue. The pathogenesis of this condition remains an enigma. Endometriosis has well known associations with menopause both in terms of secondary outcomes from medical and surgical therapy in premenopausal women, as well as a natural occurrence/recurrence of the disease in women going through menopause naturally. This review article aims to discuss the current day modalities of management of endometrios… Show more

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Cited by 12 publications
(5 citation statements)
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“…However, the exact reason for progression of endometriosis in postmenopausal patients without this therapy is not clear. In menopausal women, estrogen may be derived from androgens by the enzyme aromatase, which is stored in adipose tissue and skin . Aromatase is also expressed in endometriotic stromal cells.…”
Section: Discussionmentioning
confidence: 99%
“…However, the exact reason for progression of endometriosis in postmenopausal patients without this therapy is not clear. In menopausal women, estrogen may be derived from androgens by the enzyme aromatase, which is stored in adipose tissue and skin . Aromatase is also expressed in endometriotic stromal cells.…”
Section: Discussionmentioning
confidence: 99%
“…The presence of endometriosis in menopausal women may be explained by several pathogenetic mechanisms, but it is still considered unclear [12]. The pathophysiology Life 2024, 14, 485 3 of 9 of postmenopausal endometriosis is even more complex than that of premenopausal endometriosis.…”
Section: Pathophysiologymentioning
confidence: 99%
“…Endometriosis is an estrogen-dependent inflammatory disease characterized by the presence of ectopic endometrial tissue. The pathogenesis of endometriosis remains enigmatic [12].…”
Section: Pathophysiologymentioning
confidence: 99%