Endometriosis and the subsequent risk of epithelial ovarian cancer

Chang, Wen Yin; Wang, Kuan Chin; Lee, Wen Ling; Huang, Nicole; Chou, Yiing Jenq; Feng, Rung Chuang; Yen, Ming Shyen; Huang, Ben; Guo, Chao-Yu; Wang, Peng Hui

doi:10.1016/j.tjog.2014.04.025

Cited by 45 publications

(30 citation statements)

References 41 publications

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“…In addition to our report, two studies investigating the risk of ovarian cancer in women with endometriosis and warned that endometrioma excision does not prevent the subsequent development of ovarian cancer . The results of our study support this finding.…”

Section: Clinical Management For Ovarian Endometriomasupporting

confidence: 86%

New knowledge and insights about the malignant transformation of endometriosis

Taniguchi

2017

J of Obstet and Gynaecol

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Endometriosis may be a definitive risk factor for ovarian cancer, the most fatal gynecological cancer. The ability of endometriosis to transform into malignancy, first described by Dr. Sampson in 1925, is considered a rare occurrence, affecting approximately 1% of ovarian endometriomas. Recently we conducted a retrospective study regarding the malignant transformation of endometriosis in Japanese women. Many studies have reported a consistent correlation between endometriosis and ovarian cancer according to histological subtypes. However, the existing epidemiological evidence linking this association is insufficient to define the role of endometriosis as a cause of ovarian cancer and to influence changes to current clinical practice. Prospective cohort studies are therefore needed to clarify this issue. Additionally, the results of many molecular studies are conflicting, and earlier studies showing the molecular aberrations involved in genomic instability and mutation that enable malignant transformation have not been replicated in later studies. Careful long-term observation of a patient with endometrioma is required to detect possible subsequent incidence of malignant transformation. More importantly, a precise strategy should be set up for better prevention, early detection, specific diagnosis and treatment targeting molecular pathogenesis to understand the mechanisms of endometriosis-associated ovarian cancer. Clinicians need to be aware of the increased ovarian cancer risk in women with endometriosis.

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Section: Clinical Management For Ovarian Endometriomasupporting

confidence: 86%

New knowledge and insights about the malignant transformation of endometriosis

Taniguchi

2017

J of Obstet and Gynaecol

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“…Two reports, a case series conducted after excision of endometrioma (18) and a cohort study investigating the risk of ovarian cancer in women with endometriosis (13), warned that the excision of endometrioma does not prevent the subsequent development of ovarian cancer, and the present results support these warnings. On the other hand, one study reports that the risk of subsequent ovarian cancer development was reduced after complete excision of endometriosis by oophorectomy (odds ratio 0.19, 95% confidence interval 0.08-0.46) in comparison with controls (12).…”

Section: Discussionsupporting

confidence: 66%

Development of ovarian cancer after excision of endometrioma

Haraguchi

Koga

Takamura

et al. 2016

Fertility and Sterility

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“…The data in the current study were that of the research database of Taiwan's National Health Insurance (NHI) program from 1996 to 2010, which contains 1 million randomly sampled beneficiaries (The Longitudinal Health Insurance Database 2000 [LHID 2000]), and the data in the LHID 2000 are representative of all beneficiaries with regard to age, sex, and insurance cost. 25 – 27 …”

Section: Methodsmentioning

confidence: 99%

“…We recorded surgical treatments for endometriosis, especially limited to the ovary, tube, and peritoneal cavity. 18 , 25 Since the surgical interventions, including hysterectomy, bilateral salpingo-oophorectomy, and bilateral oophorectomy contributed to the decreased risk of future EOC, we excluded these subjects, except those women with a diagnosis of invasive EOC during the follow-up period. 18 , 25 …”

Section: Methodsmentioning

confidence: 99%

“… 11 Although many hypotheses have been put forth to explain this observation, including the presence of many confounding factors (Fig. 1 ), 18 – 25 one of the most likely reasons might involve the selected population for study. Dr. Buis found that the risk of EOC-associated endometriosis was much higher, if the data of the diagnosed endometriosis were validated by the nationwide pathology database.…”

Section: Introductionmentioning

confidence: 99%

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