Endometriosis and Inflammation in Infertility

Halis, G; Arıcı, Aydın

doi:10.1196/annals.1335.032

Cited by 139 publications

(104 citation statements)

References 154 publications

(233 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Halis and Arici (2004) have reported that most of the inflammatory reactions occur at the earlier stages of the disease, when most cytokines, chemokines and growth factors are secreted into peritoneal fluid. Haney et al (1991) showed an inverse relationship between the total number of peritoneal macrophages and the extension of pelvic endometriosis.…”

Section: Discussionmentioning

confidence: 99%

Serum interleukin-6 levels are elevated in women with minimal–mild endometriosis

Martínez¹,

Garrido²,

Coperias³

et al. 2006

Human Reproduction

View full text Add to dashboard Cite

BACKGROUND: There is a need for a reliable marker of endometriosis, especially in early stages of peritoneal disease during which imaging is not effective. The use of serum interleukin (IL)-6 as a marker is controversial. To readdress the matter, patients undergoing laparoscopy were prospectively evaluated for serum IL-6 levels. MATERIALS AND METHODS: A total of 119 women 31 years old who underwent laparoscopy were divided into groups: control patients (n = 38) with no pathologic findings; endometriosis sufferers (n = 47) with minimal-mild (MM, n = 11) or moderate-severe (MS, n = 36) endometriosis; uterine myomas (n = 13) and benign ovarian pathologies (n = 21). Blood was drawn on cycles days 5-12 and stored for subsequent analysis of IL-6 and carbohydrate antigen (CA)-125 levels. RESULTS: Serum IL-6 levels were significantly (P = 0.002) higher in women with MM endometriosis (29.4 ± 9.0 pg/ml) than in controls (15.7 ± 9.3 pg/ml). When all the non-endometriosis patients were grouped together (n = 72) and serum IL-6 (17.8 ± 12.1 pg/ml) compared with MS (n = 36; 17.6 ± 10.3 pg/ml) and MM (n = 11; 29.4 ± 9.0 pg/ml) endometriosis significantly (P < 0.01) higher levels in MM endometriosis were observed as compared to the other two groups. Serum Ca-125 levels were significantly (P < 0.01) elevated in MS endometriosis. A serum IL-6 threshold of 25.75 pg/ml afforded a sensitivity of 75% and specificity of 83% in the diagnosis of MM endometriosis. Sensitivity and specificity for CA-125 in the diagnosis of MS endometriosis, using 35 IU/ml as the cut-off value, were 47% and 97%, respectively. CONCLUSIONS: IL-6 is a reliable non-invasive marker of MM endometriosis, whereas Ca-125 is of use as a marker of severe cases.

show abstract

Section: Discussionmentioning

confidence: 99%

Serum interleukin-6 levels are elevated in women with minimal–mild endometriosis

Martínez¹,

Garrido²,

Coperias³

et al. 2006

Human Reproduction

View full text Add to dashboard Cite

show abstract

“…Kerusakan tuba fallopi disebabkan karena penyakit radang panggul, endo-metriosis, dan riwayat operasi sebelumnya. 22,23 Pada penelitian ini infeksi Chlamydia trachomatisdi masa lampau merupakan faktor yang berbeda secara signifikan pada subyek dengan kerusakan tuba fallopi yang dideteksi melalui IgG Chlamydia trachomatis (p = 0,01), sedangkan endometriosis dan riwayat operasi pada penelitian ini didapat hasil yang tidak signifikan (p = 0,26 dan p = 0,27) seperti tercantum dalam tabel 2. Hal ini dapat menjadi indikasi bahwa infeksi Chlamydia trachomatis sebagai penyebab kerusakan akibat proses inflamasi pada tuba fallopi dan penanda infeksi ini sebagai prediktor terhadap kondisi tuba fallopi.…”

Section: Kondisi Tuba Fallopi Berdasar Temuan Laparoskopiunclassified

Tingginya Infeksi Chlamydia trachomatis pada Kerusakan Tuba Fallopi Wanita Infertil

Sariroh

Primariawan

2015

MOG

View full text Add to dashboard Cite

Tujuan: Untuk mengetahui gambaran infeksi C. trachomatis pada kerusakan tuba fallopi wanita infertil. Bahan dan Metode: Penelitian ini melibatkan 42 wanita yang menjalani laparoskopi dalam tata laksana infertilitasnya. Infeksi C. trachomatis diperiksa menggunakan metode PCR dari usapan endoserviks dan IgG C. trachomatis diperiksa menggunakan metode ELISA dari darah vena. Kondisi tuba fallopi dilakukan evaluasi saat laparoskopi. Hasil: Didapatkan C. trachomatis sebesar 14,29% dari PCR usapan endoserviks dan 38,10% dari IgG C. trachomatisdi darah. Sebagian besar tuba fallopi pada subyek dengan infeksi C. trachomatis menunjukkan kerusakan, ditandai adanya adhesi perituba, oklusi tuba, fimosis fimbria atau hidrosalping saat laparoskopi. IgG C. trachomatis berbeda signifikan pada kerusakan tuba fallopi (p = 0. 01), sedangkan endometriosis dan riwayat operasi sebagai faktor risiko tidak didapatkan perbedaan yang signifikan (p = 0. 26 dan p = 0. 27). Subyek dengan IgG C. trachomatis memiliki OR: 5. 5 (95% CI 1. 42-21. 7)untuk terjadi kerusakan tuba fallopi. IgG C. trachomatis memiliki sensitifitas 62,5%, spesifisitas 81,25%, PPV 62,5% dan NPV 81,25% dalam mendeteksi kerusakan tuba fallopi bila dikonfirmasi dengan hasil laparoskopi. Simpulan: Angka kejadian infeksi C. trachomatis pada wanita infertil cukup tinggi. Pemeriksaan IgG C. trachomatis dapat menjadi penanda adanya kerusakan tuba fallopi.Kata Kunci: C. trachomatis, infertilitas, kerusakan tuba fallopi, IgG, PCR Objectives: To know the description of C. trachomatis infection in tubal dysfunction of infertile women Materials and Methods: This study involves 42 women who underwent laparoscopy procedure in their infertility work up. Chlamydia trachomatis was detected using PCR from endocervical swabs and IgG was detected using ELISA from blood. Evaluation of the fallopian tube was done during laparoscopy procedure. Results: C. trachomatis was detected in 14,29% by PCR of endocervical swab and IgGin serum was detected in 38,10%. Most of the infected women in this study have fallopian tube dysfunction, confirmed by laparoscopic visualization of peritubal adhesion, tubal occlusion, fimbriae phimosis, or hydrosalphing. IgG C. trachomatis is significantly different between normal and dysfunctional fallopian tube (p = 0. 01). The occurrence of endometriosis and previous surgery was not statistically different (p = 0. 26 and p = 0. 27). Women with IgG C. trachomatis had OR: 5. 5 to get fallopian tube dysfunction(95% CI, 1. 42-21. 7). IgG C. trachomatis has sensitivity of 62. 5% and specificity of 81. 25%, PPV of 62,5% and NPV of 81,25% in detecting dysfunctional tube compared to laparoscopy. Conclusion:The incidence of C. trachomatis infection is quite high in infertile women. IgG Chlamydia trachomatis can be used as a marker of fallopian tube dysfunction. Keywords: Chlamydia trachomatis, infertility, fallopian tube dysfunction, IgG, PCRCorrespondence: Wafi Sariroh, Departemen Obstetri dan Ginekologi, Fakultas Kedokteran Universitas Airlangga, RSUD Dr. Soetomo, Sur...

show abstract

“…Another report indicates a fecundity of 0.15-0.20 per month in normal couples but 0.02-0.10 in untreated women with endometriosis and infertility [4]. Therefore in women with stage III-IV monthly probability to conceive is 2-10% vs. 15-25% in healthy couples [5].…”

Section: Endometriosis and Ivfmentioning

confidence: 99%