Endometriosis and human infertility: a new investigation into the role of eutopic endometrium

Minici, Francesca; Tiberi, Federica; Tropea, Anna; Orlando, Mariateresa; Gangalè, Maria Francesca; Romani, Federica; Campo, Sebastiano; Bompiani, A; Lanzone, Antonio; Apa, Rosanna

doi:10.1093/humrep/dem399

Cited by 81 publications

(62 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…One study demonstrated that the addition of human recombinant IL-6 to culture medium suppressed the rate of blastocyst formation of mouse embryos , suggesting that increased IL-6 in the peritoneal fluid of endometriosis patients may contribute to infertility by adversely affecting embryonic development. Moreover, other authors (Minici et al, 2008) showed that in endometriosis, the milieu surrounding the uterine cavity may be involved in impaired eutopic endometrial stromal cell decidualization, partially due to increased peritoneal levels of TNF-. So they concluded that in endometriosis either intrinsic defects of endometrial stromal cell differentiation or the biochemical environment of the uterine cavity could concur to compromise the normal decidualization required for optimal implantation.…”

Section: Cytokines and Endometriosis Related To Infertilitymentioning

confidence: 99%

Endometriosis and Angiogenic Factors

Artini¹,

Ruggiero²,

Papini³

et al. 2012

Endometriosis - Basic Concepts and Current Research Trends

View full text Add to dashboard Cite

Section: Cytokines and Endometriosis Related To Infertilitymentioning

confidence: 99%

Endometriosis and Angiogenic Factors

Artini¹,

Ruggiero²,

Papini³

et al. 2012

Endometriosis - Basic Concepts and Current Research Trends

View full text Add to dashboard Cite

“…Whether this defect is due to abnormal endometrium or defective embryos is debated (Table 1). Minici et al suggested that the milieu surrounding the uterine cavity, particularly increased peritoneal levels of TNF-α, compromise the normal decidualization required for optimal implantation [55]. Lessey et al in their study reported a reduced expression of αvβ3 integrin, a cellular adhesive molecule in the endometrium of patients with endometriosis during the window of implantation [56].…”

Section: Endometriosis and Implantationmentioning

confidence: 99%

“…TNF-α has been implicated in the pathophysiology of endometriosis and its associated infertility. It affects sperm motility and also shows embryotoxic effects [23,55].…”

Section: Endometriosis and Immune-endocrine Interactionmentioning

confidence: 99%

Laparoscopic surgery for endometriosis-associated infertility: a pathophysiologic approach

Pahlajani

Falcone

2010

Gynecol Surg

View full text Add to dashboard Cite

Endometriosis has been one of the most confusing gynecological diseases since it was first described. Whereas there is a reasonable body of evidence in literature to demonstrate an association between endometriosis and infertility, a definite cause and effect relationship has not been established. The mechanism by which endometriosis causes infertility remains an enigma. Virtually every aspect of reproduction in women with endometriosis has been investigated and purported to be impaired. Impairment of implantation and pregnancy rates seems to affect women with endometriosis. Whether this is due to poor quality embryos derived from impaired oocytes or endometrial defects or both has been argued. Structural abnormalities of the uterine wall and tube in women with endometriosis have also been described by other researchers. Adding more confusion to this topic is the altered immune function and the peritoneal environment and their detrimental effects on the sperm motility and morphology. This uncertain pathophysiology has resulted in the lack of consensus on the treatment of endometriosis-associated infertility. The aim of this review is to describe the current pathophysiology of endometriosis-related infertility, how laparoscopic surgery may influence fertility rates.

show abstract

“…Many mechanisms have been proposed to cause fertility problems in endometriosis. These include altered folliculogenesis (Doody et al, 1988), leading to ovulatory dysfunction and low quality oocytes, as well as luteal phase defects (Grant, 1966), impaired fertilization (Wardle et al, 1985), and abnormal embryogenesis (Garrido et al, 2002), abnormalities in peritoneal fluid (Minici et al, 2008), eutopic endometrium and immunological abnormalities (Akoum et al, 2006). It seems that not one mechanism is responsible for the reduced fecundability in endometriosis it is rather a complex of several mechanisms rather than one mechanism.…”

Section: Infertility and Endometriosismentioning

confidence: 99%