Endometriosis and Cancer

Králíčková, Milena; Losan, P.; Větvička, Václav

doi:10.2217/whe.14.43

Cited by 28 publications

(35 citation statements)

References 52 publications

(62 reference statements)

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“…These alterations are summarized in Table 4. Although endometriosis is considered a ‘benign’ disease, it resembles the biologic behavior of malignant cells [113,114], and a change in the expression of various junctional proteins may support the invasive properties of this tissue and may facilitate its growth at ectopic localizations. Moreover, these impairments may also contribute to endometriosis-associated infertility.…”

Section: Direct Cell–cell Interactions In Endometrial Pathophysiologymentioning

confidence: 99%

Direct Cell–Cell Interactions in the Endometrium and in Endometrial Pathophysiology

Grund

Grümmer

2018

IJMS

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Cell contacts exhibit a considerable influence on tissue physiology and homeostasis by controlling paracellular and intercellular transport processes, as well as by affecting signaling pathways. Since they maintain cell polarity, they play an important role in cell plasticity. The knowledge about the junctional protein families and their interactions has increased considerably during recent years. In contrast to most other tissues, the endometrium undergoes extensive physiological changes and reveals an extraordinary plasticity due to its crucial role in the establishment and maintenance of pregnancy. These complex changes are accompanied by changes in direct cell–cell contacts to meet the various requirements in the respective developmental stage. Impairment of this sophisticated differentiation process may lead to failure of implantation and embryo development and may be involved in the pathogenesis of endometrial diseases. In this article, we focus on the knowledge about the distribution and regulation of the different junctional proteins in the endometrium during cycling and pregnancy, as well as in pathologic conditions such as endometriosis and cancer. Decoding these sophisticated interactions should improve our understanding of endometrial physiology as well as of the mechanisms involved in pathological conditions.

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Section: Direct Cell–cell Interactions In Endometrial Pathophysiologymentioning

confidence: 99%

Direct Cell–Cell Interactions in the Endometrium and in Endometrial Pathophysiology

Grund

Grümmer

2018

IJMS

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“…Typically, malignant transformation of endometriosis may result in endometrioid adenocarcinoma and clear cell carcinoma, as well as, Müllerian-type mucinous and serous borderline tumors, and adenosarcoma and endometrial stromal sarcoma [63]. Available epidemiological studies also indicated that women with endometriosis may be at a higher risk of extra-ovarian cancers, for example, non-Hodgkin's lymphoma, brain tumors, endocrine cancer, breast cancers, and cutaneous melanoma [65][66][67][68]. Figures 4 and 5 summarize the estimated effect sizes reported in various studies on association between endometriosis and ovarian or extra-ovarian cancers.…”

Section: Endometriosis-associated Cancersmentioning

confidence: 99%

How Benign is Endometriosis: Multi-Scale Interrogation of Documented Evidence

Ghosh

Anupa

et al. 2019

COGO

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Endometriosis is an inflammatory disease characterized by the presence of endometrium-like tissue outside the uterus primarily on pelvic organs and tissues. It affects up to 15% of women in the reproductive age group and is often associated with pelvic pain and subfertility. Different theories explain how retrograde menstruation gives rise to endometrial deposits at ectopic sites, and how several other factors are involved in the progression of the disease. Its final diagnosis is established through direct visualization at laparoscopy or surgery followed by histological confirmation. Available epidemiological reports along with histopathological observations and molecular studies shed interesting light on the pathogenetic basis of different variants of the disease like deep infiltrating endometriosis and ovarian endometriosis. Evidence also suggests that endometriosis is a neoplastic condition which serves as a precursor of ovarian and endometrial cancers. In the present review, we have attempted to take a stock of the current epidemiological and molecular knowledge regarding endometriosis associated cancers and develop a model of functional network with interactions among critical genomic factors regulating cellular processes leading to fibrotic reaction. It is being conjectured that cyclic bleeding associated with inflammatory and oxidative stress followed by repeated tissue injury and repair along with recurrent estrogenic stimulation and ovulatory events in the pelvic environment bring about the complex phenotype of atypical endometriosis and associated neoplasm with a trade-off malignant transformation in high risk population. Finally, we have presented an algorithm for pre-emptive monitoring and management of endometriosis-associated cancers.

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“…It is a high MW glycoprotein originally used as a tumor marker for ovarian tumors (Bast et al, 1981). Its use in endometriosis is based on a well-established connection between endometriosis and ovarian cancer (Kralickova et al, 2014). However, it is important to remember that it cannot be used for differential diagnosis between endometriosis and cancer, as the level is increased in patients with both endometriosis and cancer (Lenhard et al, 2009).…”

Section: Tumor Markers Ca125 and Ca19-9mentioning

confidence: 99%