Endometrioid adenocarcinoma of the ovary and endometriosis

Ramos, Pedro; Redondo, Susana Arroyo; Cabrera, Yoan Hernández; Álvarez, Íngrid; Ruiz, Andrés García

doi:10.1016/j.ejogrb.2006.06.008

Cited by 30 publications

(17 citation statements)

References 17 publications

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“…First, direct transformation, a transition from benign to malignant epithelium, is often evident (17,22,25). Second, iron released by hemorrhage in the endometrial cyst induces persistent oxidative stress and frequent DNA mutations (41).…”

Section: Discussionmentioning

confidence: 99%

“…Endometrial cancer/hyperplasia is more frequently diagnosed with EEOC (9.1-38.6%) as a synchronous tumor compared with other epithelial ovarian cancers, including OCCC (16)(17)(18). The purpose of this study was to investigate the prevalence of the coexistence of endometriosis in patients with EEOC and their related clinical manifestations.…”

Section: Introductionmentioning

confidence: 99%

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Clinical Presentation of Endometrioid Epithelial Ovarian Cancer with Concurrent Endometriosis: A Multicenter Retrospective Study

Lim

Chun

Shin

et al. 2010

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background: Endometrioid epithelial ovarian cancer (EEOC) is frequently diagnosed in conjunction with endometriosis and is suggested to arise during the process of endometriosis. This study evaluates the clinical manifestations, including endometriosis-related symptoms and their relationships according to the coexistence of endometriosis.Methods: Using medical records, a retrospective analysis was conducted on 221 patients treated for EEOC at four tertiary educational hospitals between 2000 and 2008. The initial presenting symptoms, particularly those related to endometriosis, were examined in relation to the coexistence of endometriosis or other clinical variables.Results: Endometriosis was identified in 82 (37.1%) of the 221 patients with EEOC. The most common symptoms were pelvic pain followed by gastrointestinal symptoms, palpable mass, abdominal distension, vaginal bleeding, and newly developed or exacerbated dysmenorrhea (18.1%) and dyspareunia (13.6%). Notably, dysmenorrhea and dyspareunia were frequently observed in patients with endometriosis. Among 210 patients identified with pretreatment serum CA-125, 54 (25.7%) displayed normal CA-125 levels (<35 units/ mL) and 23.3% and 29.9% of patients without and with endometriosis had normal CA-125 levels, respectively (P = 0.381). Additionally, 32.6% of the patients with early-stage EEOC displayed normal CA-125 levels.Conclusions: In this large series of patients with EEOC, the main presenting symptoms were pelvic pain followed by gastrointestinal symptoms, palpable mass, abdominal distension, vaginal bleeding, and newly developed or exacerbated dysmenorrhea and dyspareunia. Dyspareunia and dysmenorrhea were more frequently detected in patients with endometriosis. Normal CA-125 levels cannot be applied as a marker to exclude EEOC, particularly at the early stages. Cancer Epidemiol Biomarkers Prev; 19(2); 398-

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Clinical Presentation of Endometrioid Epithelial Ovarian Cancer with Concurrent Endometriosis: A Multicenter Retrospective Study

Lim

Chun

Shin

et al. 2010

Cancer Epidemiology, Biomarkers &Amp; Prevention

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“…4,19,21 Ovarian borderline tumors and endometrioid adenocarcinoma are known to arise in endometriotic foci, and atypia and hyperplasia have been shown to have prognostic significance. 19,21,22 Hence, a diligent search for these precursor lesions is warranted in all cases of PE. FFPE cell blocks not only facilitate detection of these changes, they also provide preservation of precious cytologic material for advanced molecular studies.…”

Section: Discussionmentioning

confidence: 99%

The Adjunctive Value of CD10 Immunostaining on Cell Block Preparations in Pelvic Endometriosis

Dharan¹

2009

Acta Cytologica

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“…Although endometriosis is a benign process, it shares some morphological and molecular features with neoplasms [15,35]. Endometriosis is characterised by altered morphology, unrestrained growth, local invasion and distant spread, and development of malignancies morphologically identical to those arising in the eutopic endometrium [40]. Endometriosis, like cancer, is characterized by development of new blood vessels (angiogenesis) and a decrease in the number of cells undergoing apoptosis [35].…”

mentioning

confidence: 99%

“…A frequency of about 1% malignant transformation has been reported in the endometriotic lesions; with 80% in the ovary and 20% in extragonadal sites being affected [38]. Pathologically, malignant transformation of endometriosis to clear cell carcinoma or endometriotic carcinoma of the ovary, via the step of atypical endometriosis was reported [30,40].…”

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confidence: 99%

Pelvic Endometriosis is Rarely Associated with Ovarian Borderline Tumours, Cytologic and Architectural Atypia: A Clinicopathologic Study

Hussein

Biscotti

Falcone

2008

Pathol. Oncol. Res.

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Endometriotic foci, especially ovarian ones, with epithelial cytologic atypia may be precursors of cancer. This study presents an overview of the atypical cytological and histopathological findings associated with endometriosis. Six cases of endometriosis, with atypical histological and cytological changes, were obtained from the archives of the Department of Pathology at Cleveland Clinic Foundation between year 2000 and 2003. The size of the base from which these cases were drawn was 2000 cases of endometriosis. The age range of the patients was from 29 to 52 years. The clinical presentations included infertility (three cases), pelvic pain (three cases), adenexal and pelvic masses (four cases). Stage IV endometriosis with extensive pelvic involvement was found in two patients. Intraoperatively, the endometriotic lesions involved the ovaries (all cases); Cul de sac (four cases); urinary bladder (two cases); sigmoid colon, hemidiaphragms, and uterine vessels (one case each). The endometriotic lesions were associated with uterine leiomyomas (two patients) and adenocarcinoma of the vagina (one patient). Histologically, in addition to endometrial type glands and stroma, usually found in endometriosis, we observed both cytologic and pattern atypism involving the epithelium in all cases. The features of cytologic atypia included nuclear stratification, hyperchromatism, and pleomorphism. The features of pattern atypia were complex glandular pattern, papillary formations and psammoma bodies. In two cases, these features were sufficient for diagnosis of borderline Mullerian seromucinous tumours. One patient had recurred with metastatic adenocarcinoma of the vault. She died later from disseminated metastatic disease. There is a rare association between pelvic endometriosis and borderline ovarian tumours (three cases), cytologic and pattern atypia (two cases); mesothelial hyperplasia, endosalpingiosis (two cases), and metastasis (one case). Cytologic and pattern atypia can develop in the endometriotic foci and therefore, these lesions should be thoroughly scrutinized for presence of these changes. Our findings recommend surgical excision of these foci rather than their simple cauterization.

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Endometrioid adenocarcinoma of the ovary and endometriosis

Cited by 30 publications

References 17 publications

Clinical Presentation of Endometrioid Epithelial Ovarian Cancer with Concurrent Endometriosis: A Multicenter Retrospective Study

Clinical Presentation of Endometrioid Epithelial Ovarian Cancer with Concurrent Endometriosis: A Multicenter Retrospective Study

The Adjunctive Value of CD10 Immunostaining on Cell Block Preparations in Pelvic Endometriosis

Pelvic Endometriosis is Rarely Associated with Ovarian Borderline Tumours, Cytologic and Architectural Atypia: A Clinicopathologic Study

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