Endometrial vascularity and ongoing pregnancy after IVF

Maugey-Laulom, B.; Commenges-Ducos, M.; Jullien, Véronique; Papaxanthos-Roche, Aline; Scotet, Virginie; Commenges, Daniel

doi:10.1016/s0301-2115(02)00102-1

Cited by 52 publications

(18 citation statements)

References 16 publications

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“…Our results are in agreement with Applebaum [2]. In the studies conducted by Chien et al [13] and Maugey-Laulon et al [15], absent endometrial vascularization was associated with significantly lower pregnancy rate. It has been postulated that a better endometrial and subendometrial vascularity can lead to a better placental development during pregnancy which is associated with a lower risk of miscarriage and a higher chance of live birth following ART [10].…”

Section: Endometrial Blood Flowsupporting

confidence: 93%

Ultrasonography and Doppler Study to Predict Uterine Receptivity in Infertile Patients Undergoing Embryo Transfer

Khan¹,

Shaikh²,

Ratnani³

2015

J Obstet Gynecol India

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About the Author AbstractPurpose To detect whether ultrasonographic parameters and Doppler analysis of uterine blood flow can be of value in the prediction of endometrial receptivity in infertile female patients undergoing embryo transfer. Methods In this study, a total of 200 women with primary infertility undergoing embryo transfer were analyzed. Transvaginal ultrasonography was done on the 10th day of the menstrual cycle. To assess the uterine receptivity, we analyzed all the ultrasonographic and Doppler parameters. The slightly modified version of Applebaum Uterine Scoring System was used. This uterine scoring system included all the following parameters: endometrial thickness, endometrial morphology, endometrial blood flow within zone 3, myometrial echogenecity, uterine artery pulsatility index (PI), end diastolic blood flow, and myometrial blood flow internal to the arcuate vessels seen on gray-scale examination. Results The pregnancy rates were higher in women with thick, distinct five-line endometrium and multifocal endometrial vascularity within zone 3. Absent endometrial flow, despite highest values for the other parameters, was associated with no conception. In our study, no pregnancy occurred with uterine PI values of more than 2.8. Absence or reversal of end diastolic blood flow was associated with no conception. A maximum score of 20 was associated with the pregnancy rate of 97.4 %, whereas scores of 13 or less resulted in no pregnancies. 123Conclusion Uterine scoring system will help to perform embryo transfers in only favorable uteri and postpone or cancel those cycles in which poor uterine score is demonstrated.

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Section: Endometrial Blood Flowsupporting

confidence: 93%

Ultrasonography and Doppler Study to Predict Uterine Receptivity in Infertile Patients Undergoing Embryo Transfer

Khan¹,

Shaikh²,

Ratnani³

2015

J Obstet Gynecol India

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“…Whilst the relationship between endometrial blood flow and PR has been evaluated in many studies in fresh in vitro -fertilization-embryo transfer (IVF-ET) cycles,[57891011] there is a paucity of data in frozen-thawed embryo transfer (FET) cycles. With the advancement in the field of cryobiology and move towards elective-single embryo transfer, the need to improve PRs in FET cycles has dramatically cropped up.…”

Section: Introductionmentioning

confidence: 99%

Correlation of subendometrial-endometrial blood flow assessment by two-dimensional power Doppler with pregnancy outcome in frozen-thawed embryo transfer cycles

et al. 2014

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CONTEXT:Various markers have been proposed to evaluate endometrial receptivity, such as molecular markers and sonographic markers. Commonly used sonographic markers include endometrial thickness and pattern. A good endometrial blood flow is considered necessary for improved pregnancy outcome.AIM:The aim of the present study is to evaluate the role of subendometrial endometrial blood flow with two-dimensional-power Doppler (2D-PD) in predicting pregnancy outcome in hormone replacement frozen-thawed embryo transfer (FET) cycles.SETTING AND DESIGN:Prospective, non-randomized observational study. A total of 165 patients undergoing their first FET cycle were evaluated for subendometrial-endometrial blood flow by 2D-PD once the endometrium was ≥7 mm thick. Group A consisted of 127 women showing the presence of subendometrial-endometrial blood flow. Group B comprised of 38 women in whom subendometrial blood flow was absent. Progesterone supplement was added and transfer of 2-3 cleavage stage good quality embryos was done after 3 days.STATISTICAL ANALYSIS:Independent two-tailed t-test and Chi-square test.RESULTS:There was no significant difference in body mass index, endometrial thickness, follicle stimulating hormone, luteinizing hormone levels, number of mature oocytes, semen parameters and the number of good quality embryos in the two groups (P > 0.05). The mean age in Group A was 32.05 years and 33.73 years in Group B, and the difference was statistically significant (P = 0.04). Overall pregnancy rate (PR) was 30.90%. PRs were significantly higher in the presence of subendometrial-endometrial blood flow than in its absence (35.43% vs. 15.78%, P = 0.02). Furthermore, clinical pregnancy rate and implantation rate were significantly higher in Group A when compared to Group B (31.49% and 14.79% vs. 13.15% and 6.52%, P = 0.02 and 0.03, respectively).CONCLUSION:The presence of endometrial blood flow significantly improves cycle outcome in hormone replacement therapy-FET cycles.

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“…The absence of color Doppler mapping at the endometrial and subendometrial levels is related to a significant decrease in the implantation rate (4,5) whereas the pregnancy rate increases when vessels can be depicted reaching the subendometrial halo and the endometrium (4,6).…”

mentioning

confidence: 99%

Are endometrial parameters by three-dimensional ultrasound and power Doppler angiography related to in vitro fertilization/embryo transfer outcome?

Mercé

Barco

Bau

et al. 2008

Fertility and Sterility

139

100

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Endometrial vascularity and ongoing pregnancy after IVF

Cited by 52 publications

References 16 publications

Ultrasonography and Doppler Study to Predict Uterine Receptivity in Infertile Patients Undergoing Embryo Transfer

Ultrasonography and Doppler Study to Predict Uterine Receptivity in Infertile Patients Undergoing Embryo Transfer

Correlation of subendometrial-endometrial blood flow assessment by two-dimensional power Doppler with pregnancy outcome in frozen-thawed embryo transfer cycles

Are endometrial parameters by three-dimensional ultrasound and power Doppler angiography related to in vitro fertilization/embryo transfer outcome?

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