Endometrial thickness of less than 7.5 mm is associated with obstetric complications in fresh IVF cycles: a retrospective cohort study

Oron, Galia; Hiersch, Liran; Rona, Shiran; Prag-Rosenberg, Roni; Sapir, Onit; Tuttnauer-Hamburger, Maya; Shufaro, Yoel; Fisch, Benjamin; Ben-Haroush, Avi

doi:10.1016/j.rbmo.2018.05.013

Cited by 50 publications

(55 citation statements)

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“…uteroplacental circulation that adversely affect the growing fetus (26). While our results did not demonstrate an association between endometrial thickness and prevalence of preterm and small-for-gestational-age neonates, those of other studies have shown such association (32,33). Similarly, our results did not show an association between endometrial thickness and obstetric complication rate, while prior studies have shown significant correlations between endometrial thickness and a variety of individual obstetric complications.…”

Section: Endometrial Thickness and Birthweightcontrasting

confidence: 86%

“…Similarly, our results did not show an association between endometrial thickness and obstetric complication rate, while prior studies have shown significant correlations between endometrial thickness and a variety of individual obstetric complications. Oron et al (33) found that an endometrial thickness of <7.5 mm is associated with a 1.5-fold increased risk of adverse obstetric outcome, as defined by preeclampsia, placenta previa, placental abruption, manual removal of an adherent placenta, small-forgestational-age neonate, and preterm delivery. He et al (34) demonstrated than an endometrial thickness of <8 mm is significantly associated with an increased risk of premature rupture of membranes and postpartum hemorrhage.…”

Section: Endometrial Thickness and Birthweightmentioning

confidence: 99%

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The effect of endometrial thickness on live birth outcomes in women undergoing hormone-replaced frozen embryo transfer

2021

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Objective: To determine the impact of endometrial thickness on live birth outcomes and obstetric complication rate after hormonereplaced frozen embryo transfer. Design: Retrospective cohort study. Setting: Large, urban, academic fertility center. Patient(s): All patients with a singleton live birth after single euploid embryo transfer (by array comparative genomic hybridization or next-generation sequencing) in a hormone-replaced frozen embryo transfer cycle between January 2017 and December 2018 were reviewed. Intervention(s): None. Main Outcome measure(s): The primary outcomes were birth weight and obstetric complication rate. Result(s): A total of 492 patients were included. The median endometrial thickness was 8.60 mm (range, 6.0-20.0). The median gestational age at live birth was 39.4 weeks with a median birth weight of 3,345.2 g. Endometrial thickness was significantly correlated with birth weight. When patients were dichotomized into groups (those with an endometrial thickness of <7 mm and those with an endometrial thickness of >7 mm), neonates born from endometria with a thickness of <7 mm were born earlier (37.3 vs. 39.4 weeks and born with lower birth weights (2,749.9 vs. 3,345.2 g). It should be noted that only seven patients had an endometrium measuring <7 mm. Moreover, 7.1% (n ¼ 35) of patients had an obstetric complication. Endometrial thickness was not significantly associated with obstetric complications, even with adjustments for age and medical history. Conclusion(s): Endometrial thickness may be a valuable predictor of placental health and birth weight. Further study is required to examine the relationship with individual obstetric complications, as our study may not have been powered to observe differences in obstetric complication rate, as well as the relationship between endometrial thickness and outcomes in natural frozen embryo transfer cycles.

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Section: Endometrial Thickness and Birthweightcontrasting

confidence: 86%

Section: Endometrial Thickness and Birthweightmentioning

confidence: 99%

The effect of endometrial thickness on live birth outcomes in women undergoing hormone-replaced frozen embryo transfer

2021

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“…This difference may be related to the higher prevalence of hypertension during pregnancy in this group. Oron et al set an EMT cutoff of 7.5 mm, and found that the prevalence of obstetric complications in patients with EMT < 7.5 mm was increased signi cantly, including premature delivery, hypertension in pregnancy, placenta previa, and premature rupture of membranes [16]. In the present study, the EMT was divided into more detailed (i.e., three) groups, and the difference in pregnancy duration among the three groups was signi cant.…”

Section: Discussionmentioning

confidence: 50%

A thinner endometrium is associated with lower newborn birth weight during in vitro fertilization–frozen-embryo transfer: cohort study

Zhang

Luo

Han

et al. 2021

Preprint

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BackgroundThe purpose of this study is to explore the influence of endometrial thickness (EMT) before embryo transfer on birth weight after in vitro fertilization–frozen-embryo transfer (IVF–FET).MethodsThis was a retrospective cohort study. We collected the medical records associated with singleton live births from Tianjin Central Obstetrics and Gynecology Hospital from June 2015 to February 2019 after IVF–frozen-embryo transfer (FET). Patients were ≤ 42 years at delivery. Outcomes related to newborns were birth weight, gestational age, delivery mode, low birth weight, and prevalence of macrosomia. Outcomes related to pregnant women were gestational hypertension, gestational diabetes mellitus, premature rupture of membranes and placenta previa.ResultsThe birth weight of singleton newborns was higher for newborns delivered by patients with EMT > 12 mm before embryo transfer than newborns delivered by patients with a thinner endometrium. Regression analysis showed that the EMT ≥ 12 mm group had a gain in mean birth weight of 85.107 g compared with that in the EMT < 8 mm group, whereas the group with EMT of 8–12 mm had an increase in mean birth weight of 25.942 g compared with that in the EMT < 8 mm group. Hypertension during pregnancy, premature rupture of membranes, placenta previa, newborn sex, gestational age, delivery mode, number of implanted embryos, follicle-stimulating hormone (FSH) level, estradiol (E2) level, and pre-pregnancy body mass index (BMI) were all independent predictors of newborn birth weight. The regression model for predicting the newborn birth weight was: Y (birth weight) = 25.942×(EMT of 8–12 mm) + 85.107×(EMT > 12 mm) + 123.483×(hypertension during pregnancy) + 148.859×(premature rupture of membranes) + 182.342×(placental position) − 126.242×(newborn sex) + 23.837×(number of days of pregnancy) + 130.487×(delivery mode) − 55.023×(number of implanted embryos) − 6.215×FSH level − 1.124×E2 level + 22.218×BMI − 4468.101.Conclusion(s)EMT before embryo transfer in patients undergoing their first freeze–thaw embryo transfer cycle is related to the weight of newborn singletons. The newborn birth weight for patients with a thinner endometrium is lower. EMT should be increased before embryo transfer to improve neonatal outcomes after fertility treatment.

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“…The thicker the EMT, the higher the possibility of live birth after fresh ET (26). Conversely, if the EMT is low on hCG trigger day, various complications may occur during pregnancy, which will also reduce the ART live birth rate (27)(28)(29).…”

Section: Discussionmentioning

confidence: 99%

Thicker endometrium on hCG trigger day improves the live birth rate of fresh cleavage embryo transfer in GnRH-agonist regimen of normogonadotrophic women

Luo¹,

Li²,

Zheng³

et al. 2021

Ann Transl Med

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Background: Luteinizing hormone (LH) and progesterone (PROG) on human chorionic gonadotropin (hCG) trigger day are significantly correlated with assisted reproductive technology (ART) outcome.Moreover, LH and PROG are also involved in the functional preparation of the endometrium during the implantation window; however, whether they are related to endometrial thickness (EMT) is still unknown.The aim of the present study was to assess whether EMT has a positive correlation on the live birth rate following fresh embryo transfer (ET), and whether LH and PROG have an impact on EMT.Methods: A total of 2,260 normogonadotrophic women were treated with a GnRH agonist for in vitro fertilization (IVF)/intracytoplasmic sperm injection. Patients with advanced age and poor ovarian reserve were excluded. The levels of LH, PROG, and EMT on the hCG trigger day were divided into binary variables, respectively, by the cutoff values, and which were obtained based on receiver operating characteristic curve analysis of live birth among LH, PROG and EMT levels on the hCG trigger day, respectively. Multivariate binary logistic regression was used to confirm the role of LH, PROG, and EMT on the live birth, and stratified analysis was used to determine whether LH and PROG have an impact on EMT.Results: EMT and LH were protective factors for live births, with odds ratios (OR) of 1.11 [95% confidence interval (CI): 1.066-1.157] and 1.696 (95% CI: 1.345-2.139), respectively. However, PROG was a risk factor for live birth, with an OR of 0.635 (95% CI: 0.526-0.766). The hierarchical cross-table analysis indicated that EMT had no significant difference for live birth in the combination of low LH and high PROG group. In the other subgroups, thick EMT was associated with a higher live birth rate (P<0.05).Conclusions: On hCG trigger day, EMT, LH, and PROG all were independent factors that affected the live birth of fresh ETs. Thick EMT can significantly increase the live birth rate. However, multivariate logistic regression analysis showed that EMT does not affect the live birth rate in combination of low LH and high PROG environment.

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Endometrial thickness of less than 7.5 mm is associated with obstetric complications in fresh IVF cycles: a retrospective cohort study

Cited by 50 publications

References 48 publications

The effect of endometrial thickness on live birth outcomes in women undergoing hormone-replaced frozen embryo transfer

The effect of endometrial thickness on live birth outcomes in women undergoing hormone-replaced frozen embryo transfer

A thinner endometrium is associated with lower newborn birth weight during in vitro fertilization–frozen-embryo transfer: cohort study

Thicker endometrium on hCG trigger day improves the live birth rate of fresh cleavage embryo transfer in GnRH-agonist regimen of normogonadotrophic women

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