Endometrial receptivity and pregnancy outcome

Neykova, Konstantsa; Tosto, Valentina; Giardina, Irene; Цибизова, В. И.; Vakrilov, Georgi

doi:10.1080/14767058.2020.1787977

Cited by 26 publications

(22 citation statements)

References 111 publications

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“…In addition, several studies have shown that one of the causes of the low pregnancy rate in humans is an overly thin endometrial lining [5]. The same thing was expressed by Neykova et al in 2020 which stated that the success of the implantation process was determined by the quality of the embryo, the readiness of the endometrium to accept the results of conception and molecular interactions and communication between cells [6].…”

Section: Introductionmentioning

confidence: 90%

“…Most of the endometrium is released during menstruation, which then grows again in the proliferation phase followed by the sectoral phase [8]. Figure 1 shows these structural and functional changes in order to prepare for blastocyst implantation and to support embryonic growth in early pregnancy [6]. The implantation process consists of apposition, adhesion or attachment, invasion or penetration and decidualization or formation of decidua.…”

Section: Endometriummentioning

confidence: 99%

“…Based on the results of the study, Cohen et all stated that patients with In Vitro Fertilization who experienced repeated implantation failure need to consider endometrial histology during the secretion phase [7]. In fact, various studies are currently being developed to evaluate the condition of the endometrium through genetic improvement, the use of new biomarkers, non-invasive methods and even sophisticated methods such as the Endometrial Receptivity Assay (ERA) proteomic technique in order to overcome infertility problems in women [6].…”

Section: Introductionmentioning

confidence: 99%

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Characteristics of Endometrial Cells and the Factors that Influence the Implantation Process

Larasati¹

2021

JEN

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Infertility is a global health problem faced by 8 - 10% of couples in the world. It means 50 - 80 million couples have infertility problem. Knowledge about comprehensive and profound reproductive system is main asset for managing infertility. When look at various factors those contribute to women infertility, so the role of endometrium is very important. The optimal endometrial environment for receiving blastocyst is a major factor in the process of implantation and pregnancy. This study attempts to review and compare sources from research article, case report, and reviews from reputable international journals. Research by Germeyer et all (2010) shows that optimal growth and development of endometrium are factors those greatly contributes for successful implantation which is continued to pregnancy. The same thing is revealed by Neykova review (2020) which states the success implantation process is determined by the quality of the embryo, the readiness of the endometrium to accept the result of conception and interaction, and communication of molecular cells. Currently, various studies are being developed for evaluating endometrium condition through genetic improvement, the use of new biomarkers, non-invasive method even sophisticated method such as proteomic technique Endometrial Receptivity Assay (ERA) in order to solve women infertility problem.

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Section: Introductionmentioning

confidence: 90%

Section: Endometriummentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Characteristics of Endometrial Cells and the Factors that Influence the Implantation Process

Larasati¹

2021

JEN

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“…Endometrial receptivity is defined as the ability of the endometrium to accept an embryo implantation ( 53 , 54 ). Studies directed at the potential molecular mechanisms that may be involved, centered on protein-coding genes in the field of assisted reproduction ( 55 ).…”

Section: Circrnas In Other Endometrial Diseasesmentioning

confidence: 99%

Current and Future Roles of Circular RNAs in Normal and Pathological Endometrium

Yang

Chen

et al. 2021

Front. Endocrinol.

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The uterine endometrium, which lines the mammalian uterus, is essential for embryo implantation. This lining undergoes significant changes during sexual and menstrual cycles. The endometrium is also associated with hormone-related diseases such as endometriosis and endometrial cancer. Circular RNAs (circRNAs) play a role in various biological processes. Recent studies have determined that circRNAs function in both normal and pathological endometrial environments. Here, we review high-throughput studies pertaining to circRNAs as well as individual circRNAs active in the endometrium, in order to explore the myriad functions of circRNAs in the endometrium and mechanisms underlying these functions, from panoramic and individual perspectives. Owing to their abundant expression, stability, and small size, circRNAs have displayed potential usefulness as diagnostic markers and treatment targets for endometrial-related diseases. Therefore, the specific role of circRNAs in the endometrium warrants systematic investigation in the future.

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“…Recurrent implantation failure (RIF) refers to the failure of achieving a pregnancy after at least three in vitro fertilization (IVF) cycles in which one or two high-grade embryos are transferred (Ruiz-Alonso et al, 2013;Polanski et al, 2014;Bashiri et al, 2018;Zhou et al, 2019). Successful implantation requires a receptive endometrium, a functional embryo and a synchronized communication between maternal and embryonic sides (Neykova et al, 2020). In RIF patients, endometrial dysfunction and poor embryo quality are the most crucial causes of implantation failure (Kliman and Frankfurter, 2019;Patel et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

Deficiency of Sirtuin 1 Impedes Endometrial Decidualization in Recurrent Implantation Failure Patients

Jia

Yao

et al. 2021

Front. Cell Dev. Biol.

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Decidualization is driven by differentiation of human endometrial stromal cells (ESCs), and is a prerequisite for successful implantation and establishment of pregnancy. The critical role of impaired decidualization in women suffered recurrent implantation failure (RIF) has been established, while the underlying mechanism is poorly understood. In the present study, we verified the essential role of Sirtuin1 (SIRT1) in regulating differentiation and maintaining reactive oxygen species (ROS) homeostasis of human ESCs during decidualization. The abundance of SIRT1 was decreased in RIF patients both in the endometria during window of implantation phase and in the decidualized ESCs. Downregulation of SIRT1 disrupted the intracellular ROS homeostasis during decidualization of ESC, manifested as the accumulation of intracellular ROS level and the reduction of antioxidant stress molecules. Elimination of ROS with N-acetyl-L-cysteine (NAC) could rescued the decidualization inhibition caused by SIRT1 knockdown. Further, we explored the insufficient expression of SIRT1 in ESC affected the deacetylation of forkhead box O1 (FOXO1), and thus inhibited the transcriptional activity of FOXO1. This could account for the dysregulation of intracellular ROS homeostasis during decidualization and decreased expression of decidual markers. Collectively, our findings provided insight into the role of down-regulated SIRT1 in the poor decidual response of ESCs in RIF patients.

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Endometrial receptivity and pregnancy outcome

Cited by 26 publications

References 111 publications

Characteristics of Endometrial Cells and the Factors that Influence the Implantation Process

Characteristics of Endometrial Cells and the Factors that Influence the Implantation Process

Current and Future Roles of Circular RNAs in Normal and Pathological Endometrium

Deficiency of Sirtuin 1 Impedes Endometrial Decidualization in Recurrent Implantation Failure Patients

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