Endometrial polyp is associated with a higher prevalence of chronic endometritis in infertile women

Peng, Jintao; Guo, Jiayi; Zeng, Zhi; Liang, Xiaoyan; Zeng, Haitao; Li, Manchao

doi:10.1002/ijgo.14207

Cited by 6 publications

(6 citation statements)

References 23 publications

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“…Additional research has also explored the relationship between CE and other factors linked to infertility [19]. A further research observed a greater occurrence of CE among women who are unable to conceive and had endometrial polyps, indicating a possible correlation between these two disorders [20]. Furthermore, studies have examined the diagnostic significance of CD138 for CE, suggesting that CD138 immunohistochemical staining may enhance the rate and precision of CE diagnosis [21].…”

Section: Discussionmentioning

confidence: 99%

“…Nevertheless, there were no statistically significant correlations found between CE and any other variables. Furthermore, studies have shown a greater occurrence of CE among women who were unable to conceive and have endometrial polyps, suggesting a possible correlation between these two disorders [23,20]. Moreover, the diagnostic significance of CD138 in CE has been investigated, indicating that CD138 immunohistochemical staining has the potential to improve the rate and precision of CE diagnosis [19].…”

Section: Discussionmentioning

confidence: 99%

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The role of CD138 immunohistochemical marker in the diagnosis of chronic endometritis: causes of female infertility

2024

FEM

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This article focused on “The role of CD138 immunohistochemical marker in the diagnosis of chronic endometritis: causes of female infertility”. Aims: The aim of the study was to assess the diagnostic efficacy of CD138 in identifying chronic endometritis among infertile patients with endometrial pathology and to examine the association between CE and various factors related to infertility. Methodology: A cross-sectional observational study exploring the utility of the CD138 immunohistochemical marker in diagnosing chronic endometritis and its association with infertility in a sample of 63 couples. The t-test, chi-square test and logistic regression was applied using SPSS 26. Results: The study examined infertility characteristics and chronic endometritis in 63 infertile woman with pathology of endometrium. Results also established a significant association between CE and CD 138 presence, suggesting CD 138 as a potential diagnostic marker for CE. Additionally, the age was identified as a notable factor linked to CE. Factors such as abortion history, intrauterine interventions, delivery experiences, and cervical pathology, mycoplasma infections were found to have a significant correlation with CE. The logistic regression indicated a lower likelihood of CE in certain infertility types. It also identified a significant association between increased CE odds and longer fertility duration, while specific causes of fertility had a modest impact. Overall, CD 138 demonstrated its diagnostic potential for CE, age was associated with CE, and certain factors correlated with CE, emphasising the complexity of CE etiology in infertility patients with endometrial patology. Scientific Novelty: A Gateway to Understanding Female Infertility Conclusion: In conclusion, the research findings underscored the significance of CD 138 as a diagnostic marker for chronic endometritis in infertility patients. The age emerged as a notable factor associated with CE, while specific qualitative factors like delivery history exhibited a correlations with CE status, warranting further investigation

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

The role of CD138 immunohistochemical marker in the diagnosis of chronic endometritis: causes of female infertility

2024

FEM

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“…Local inflammation of the endometrium is contributing factor to the formation and recurrence of EPs, while CE involves chronic persistent inflammation of the endometrium that often coexists with EPs [ 9 , 12 , 19 , 21 ]. Our previous retrospective study showed that CE may be a risk factor for EP recurrence in premenopausal women who underwent TCRP [ 18 ].…”

Section: Discussionmentioning

confidence: 99%

“…These changes can lead to the formation of EPs. Peng et al [ 12 ] found that the occurrences of both solitary polyps and multiple polyps are positively associated with CE.…”

Section: Introductionmentioning

confidence: 99%

Chronic endometritis multiplies the recurrence risk of endometrial polyps after transcervical resection of endometrial polyps: a prospective study

Huang,

You,

Zhao

et al. 2024

BMC Women's Health

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Background To investigate the impact of chronic endometritis (CE) on the recurrence of endometrial polyps (EPs) in premenopausal women after transcervical resection of endometrial polyps (TCRP). Methods This prospective study enrolled 507 women who underwent TCRP between January 1, 2022 and December 31, 2022. The patients were divided into a CE group (n = 133) and non-CE group (n = 374) based on the expression of CD138 in the endometrium. The EP recurrence rate at 1 year after TCRP was compared between the CE and non-CE groups and between groups with mild CE and severe CE. The impact of CD138 expression by resected EPs on EP recurrence also was investigated. Results The EP recurrence rate at 1 year post-TCRP was higher in the CE group than in the non-CE group (25.6% vs. 10.4%) and also higher in the severe CE group than in the mild CE group (34.5% vs. 18.7%). Additionally, the EP recurrence rate was higher among patients with CD138-expressing EPs than among those with EPs lacking CD138 expression (30.5% vs. 6.5%). The odds ratio (OR) for EP recurrence in the CE cohort compared with the non-CE cohort was 3.10 (95% confidence interval [CI] 1.84–5.23) after adjustment for EP number and precautions against EP recurrence. The ORs for EP recurrence in patients with mild CE and severe CE were 2.21 (95%CI 1.11–4.40) and 4.32 (95%CI 2.26–8.26), respectively. Similarly, the OR for EP recurrence in cases with CD138-expressing EPs relative to cases with EPs lacking CD138 expression was 6.22 (95%CI 3.59–10.80) after adjustment for EP number and precautions against EP recurrence. Conclusions CE multiplied the recurrence rate of EPs in premenopausal women after TCRP, and this effect positively correlated with CE severity. CD138 expression by EPs also was associated with a higher risk for EP recurrence.

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“…Whether CD138-positive plasma cells were present in the endometrial tissue samples, as observed on high-power fields (HPF), was counted by an experienced pathologist (YZ). The presence of at least one CD138-positive plasma cell in the endometrial stroma per HPF (400x) was considered indicative of CE, according to previous studies [ 7 , 11 ].…”

Section: Methodsmentioning

confidence: 99%

Chronic endometritis incidence in infertile women with and without polycystic ovary syndrome: a propensity score matched study

Guo,

Chang,

Zeng

et al. 2023

BMC Women's Health

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Background Polycystic ovary syndrome (PCOS) is known to be associated with chronic low-grade inflammation and endometrial dysfunction. Chronic endometritis (CE) is a type of local inflammation that can contribute to endometrial dysfunction in infertile women. Some clinicians recommend screening for CE in women at high risk, such as those with endometrial polyps. However, it is still uncertain whether there is a relationship between PCOS and CE, as well as whether women with PCOS require enhanced screening for CE. This study was to assess the incidence of CE among infertile women with PCOS by hysteroscopy combined with histopathology CD138 immunohistochemical staining of endometrium. Methods A total of 205 patients in the PCOS group and 4021 patients in the non-PCOS group from July 2017 to August 2022 were included in this retrospective study. After nearest-neighbor 1:4 propensity score matching (PSM), 189 PCOS patients were matched with 697 non-PCOS patients. Basic information was recorded. The CE incidence was compared. The risk factors affecting CE incidence were also analyzed. Results No significantly higher CE incidence in infertile women with PCOS were found either in total analysis or after PSM (P = 0.969; P = 0.697; respectively). Similar results were discovered in the subgroup of Body Mass Index (BMI) (P = 0.301; P = 0.671; P = 0.427; respectively) as well as the four PCOS phenotypes (P = 0.157). Intriguingly, the incidence of CE increased as BMI increased in the PCOS group, even though no significant differences were found (P = 0.263). Multivariate logistic regression showed that age, infertility duration, infertility type, PCOS, and obesity were not the independent risk factors affecting CE incidence. Conclusion The incidence of CE in PCOS patients did not significantly increase compared to non-PCOS patients. Similarly, no significant differences in the incidence of CE were observed among different PCOS phenotypes. The current evidence does not substantiate the need for widespread CE screening among PCOS women, potentially mitigating the undue financial and emotional strain associated with such screenings.

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Endometrial polyp is associated with a higher prevalence of chronic endometritis in infertile women

Cited by 6 publications

References 23 publications

The role of CD138 immunohistochemical marker in the diagnosis of chronic endometritis: causes of female infertility

The role of CD138 immunohistochemical marker in the diagnosis of chronic endometritis: causes of female infertility

Chronic endometritis multiplies the recurrence risk of endometrial polyps after transcervical resection of endometrial polyps: a prospective study

Chronic endometritis incidence in infertile women with and without polycystic ovary syndrome: a propensity score matched study

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